Day: January 1, 2023

If you are over 30, the risks of shock loss after a hair transplant decrease with each year over 30, so a 35 year old will have significantly less risk of shock loss than a 30 year old, and 40 even better. This is because the miniaturization that is present in younger men, is significantly reduced as a man ages and it is these hair that get shocked. The doctor can tell you how much miniaturization you have at risk by a proper examination of you.

Dutasteride has never gone through the FDA trials in young men who wish to use it for hair loss, so without clinical studies it is all anecdotal. As dutasteride is both a type 1 and type 2 blocker and a more effective DHT blocker on the competitive inhibition side, I would suspect that the sexual side effects as well as the risk of PFS would be equal to or more than finasteride. Just a guess.

The total donor hair supply usually reflects 25% of your total hair count which is the capacity of the donor area for available hair. This post elaborates on how this is measured: https://baldingblog.com/how-do-you-determine-your-donor-density/. Assuming that the typical Caucasian has 110,000 hairs and 50,000 Follicular Units on his scalp, the number of grafts available are most likely between 50-65% of the Follicular units can be moved in a person with a hair thickness that is average (60 microns thick). If your hair is finer than that, the number of grafts plummets.

The question I believe is just how many grafts you need, as that should determine what is done. There is often a limit as to how many grafts can be removed from a strip surgery and that reflects the donor laxity (redundancy of the scalp skin) and the donor density. If too much scalp is removed, problems could develop with the wound.

A reader on Reddit answered it this way. Not a bad attempt but I can’t endorse it all. I see incidence reports that run from 1% to .1%. Here is the reddit response

0,02 % of people based on clinical studies made from pfs foundation….

This is 1 of 5000 people in lifetime during using

Of which medium time to get normal is 3 years…

3 years without medication, like trt proviron ecc

You literally have 50 more chances to die on a car accident

You have 10 more chances to die walking by street

And you have 2 times more chance to die choked on food…

So in reality is pretty safe like a drug, and to be even safer just do a blood work controlling your hormone panel….

Than after this every 6 months do hormone profile to check if everything is in range and you are good to go….

The majority of pfs, comes from hormone that was bad at the start of medication and during the medication they hormones get messed up (which can be seen on blood work) and they continue because they didnt have sides and then when they stop they body overact and pfs comes….

Other than that you can have once in a year a stop of one month, to wash the chemicals in your body, and restart again….

With all this literally the chances to get something its almost 0.

And in many reputablr clinical studies, after discontinuation of the drug, more people experienced persistence of sides on placebo grouo than the finesteride group….

Which doesnt mean that pfs fin sides doesnt exist, but many people nocebo themselfs to think that they have something which they dont, and many people have some problems in they body outside the drug

1 in 5000 is a real pfs, so if there is like 1milion consumers, we can expect that we have 200 pfs patients with it…

This number is so low, that doctors cant know how to take out this people from that, and this is why having blood work pre fin and during fin so that an endrychonologist will know how to bring you back in normal state if they have something to work with….

I am curious to know the importance of DHT, post puberty. Is it only significant for men to sexually develop during puberty? Also, is it important for cognitive activity in any way? I ask this second question due to ‘brain fog’ being a reported (although rare I believe) side effect of finasteride.

Thanks for the great site

Dihydrotestosterone (DHT) is one of the many hormones responsible for secondary male characteristics during puberty such as body hair (facial, pubic hair) growth and deepening of the voice. DHT is one of the contributing factors in prostate enlargement as men age. Thus, DHT blocking drugs (Proscar: finasteride 5mg) is sometimes used to treat certain prostate related conditions. DHT is also one of the contributing factors in Male Pattern Balding (MPB) for those who have the genes for MPB. Thus, DHT blocking drugs (Propecia: finasteride 1mg) is used to treat MBP. It is unclear how it may affect cognitive activity but you may read on the Internet that men taking DHT blockers have reported “brain fog” on rare occasions. It is also important to note all drugs have side effects and every patient need to understand the risks and benefits before starting treatment.

https://www.ftc.gov/news-events/news/press-releases/1997/02/court-order-brings-close-ftc-lawsuit-against-makers-helsinki-formula-its-baldness-cure-claims

The official half life in the blood is about 6 hours and in the body tissues is 4-7 days. But as you take the calculation forward, some will remain for a few weeks after that. I tell my patients that 4-6 weeks is a reasonable expected target.

I’m trying to figure out what the half-life of fin is, in the event I end up taking 60mg one day and 140mg the next day. How much would this impact the effectiveness of fin working for me?

Finasteride has a 6-hour half-life, however, it lasts in your tissues (hair follicles) at least 7 days or more. For that reason, you don’t have to be exact on taking it, provided that you take a total of 7 mg per week. I believe that you got your numbers wrong as 60 mgs would be 60 times the dose of a standard finasteride (Propecia or 12 times the dose or a Proscare 5mg pill).