Peer-Reviewed Studies on Dutasteride and MPB – Hair Loss Information by Dr. William Rassman

Hi Dr. Rassman,

There are two well-designed, peer-reviewed studies demonstrating the efficacy of dutasteride in preventing male pattern baldness:

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1473-2165.2007.00297.x
http://www.bernsteinmedical.com/resources/Dutasteride-Finasteride.php

In addition, here is a peer-reviewed case study:

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=…

I hope this convinces you of the efficacy of dutasteride in preventing male pattern baldness, even relative to finasteride.

Best Regards

The general consensus for dutasteride is that it grows hair. I do not believe other doctors will challenge this point too much. The real question is how much better it is when compared to finasteride. And more importantly is the safety profile of the drug and the issues of side effects when taken for an indefinite period of time. Dutasteride has a very long half life in the order of weeks versus finasteride which has a half life in the order of only hours.

Any Harm In Starting Propecia Early? – Hair Loss Information by Dr. William Rassman

Dear Dr. Rassman,

I’m 26 years old and have noticed, whether it’s due to high stress from school and my job, or from genetics, that my hairline has raised by a half-inch or one inch and that my temples have started thinning out in the past 9 months. I’m not sure if this is hair-loss or the development of a “mature hairline”. I’ve considered propecia and will get the miniaturization test done, but: assuming that one doesn’t suffer ill effects from propecia, in terms of my hair, are there any repercussions or detrimental effects to starting the medication early?

a lot of your messages suggest that it’s better to be safe than sorry; so if i am indeed losing hair slowly (albeit currently at a snail’s pace), other than loss of a few extra dollars, is there any harm in starting treatment on propecia ASAP to minimize the potential for long-term hair loss?

thank you for taking my question.

Stress can be a cause of hair loss, but the hair loss would likely occur diffusely (all over front, top, side, and back). Genetic hair loss for men (male pattern hair loss) will occur mostly on the front and top areas of the scalp – sparing the sides and back.

While Propecia is a safe medication to take, you need to have a good diagnosis to see if it will help your hair loss situation. In other words, Propecia would not help you if your hair loss is due to stress, unless you have a genetic predisposition to balding. I personally don’t like the use of Propecia without a diagnosis. Why commit a lifetime on medication if there is no balding present? Think about that!

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How Long Does Shock Loss Last? – Hair Loss Information by Dr. William Rassman

Dr. Rassman,

How long does shock fallout last for? I am more than 15 months out after my initial transplant (49 years old and on Propecia for several years) and had alot of fallout shortly after the surgery. My hair continues to fall out at a pace greater than what I experienced before the procedure. Are the hairs I am still losing possibly the result of the surgery from over a year ago? I am confused and very disappopinted with the results of my transplant as I have decidely less hair now than prior to the surgery – not exactly what I envisioned as the outcome of my procedure.

Please help with your input.

Your case brings up many points. Have you started to lose your native hair in a new cycle? You may have had shock hair loss, but that process should plateau in 3-4 months. One would have to find out if the new grafts grew. What did your surgeon say about your situation? I am coming in late in the game and would need to establish baselines as to what I am looking at before rendering an opinion.

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Scratching My Scalp So Much That I Have Bald Spots Now – Hair Loss Information by Dr. William Rassman

About a year ago I started getting some scalp problems, primarily an itch. I would scratch the itch so hard I would develop some raw areas on the scalp that would scab over. Yet I continued to scratch and pick at the scabs until I noticed patches of bald areas on the top of my head where I had been scratching and picking. Will these areas grow back hair in time? Have I damaged the roots to the point no hair will re-grow in these areas? It looks horrible. Thanks.

You are clearly developing traction alopecia and these areas may stay bald. This is an obsessive/compulsive disorder and you should see your family doctor about his/her recommendations for treatment.

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What is Regenix? – Balding Blog

What is Regenix and how is it used in conjunction with other products

To answer your questions I had to contact the company and get a list of the ingredients directly from them. Here is the list they emailed me:

Vitamins:
A, B, Series D, E, F, H1 and H2 P, Amino Benzoic Acid, Inositol, Calium d-Pantothenate, 8-Hydroxyquinolene Sulphate, Live Yeast Cell Extract, Folic Acid, Chlorobutanol, Menthyl Nicontinate, Organic Sulfur, Nucleic Acids.

Herbal Extracts:
Horse Tail, Stinging Nettle, Horse Chestnut, Birch, Burdock Root, Mistletoe, Chamomile, Hops, Balmint, Fennel, Yarrow, Soluble Collagen Derivatives, Quaternary Derivatives of Hydrolyzed Collagen Protein, Glucose, Glutamate, Biotin, Plant Protein, Saw Palmetto Berry Extract

Although presence of an adequate amount of vitamins is necessary for growth and health of hair follicles, hair follicles generally get them through blood circulation and there is no evidence to show topical vitamins have any effect on growth of hair follicles. Among the other ingredients, you can see some herbal extracts such as saw palmetto which claims some DHT blocking activities. The data on the effectiveness of topical DHT blockers are positive, but the studies are very limited and more research is needed before we can recommend those to our patients for the treatment of hair loss.

There is no direct comparison between Regenix and standard approaches with Propecia and/or minoxidil. One would need this to determine the cost effectiveness of this type of product in comparison with medications such as finasteride and minoxidil that are being used for prevention of hair loss. Those studies are just not available.




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Hair Styling When You Do Not Have Enough Hair (with Photos) – Hair Loss Information – Balding Blog

Everyone has seen those awful comb-overs and wonder how people get there. First, it is important to note these men did not wake up one morning, see that they were bald and then decide to grow out the hair above their ears to comb back to the other side. Politicians are frequently seen with these bizarre comb-overs. They develop insidiously over time. First a little hair loss, and the person starts combing their hair from one side to the other. The ‘part’ moves down over time as the hair by the ‘part’ grows longer and longer. For the first few years, this trick of styling with the patient’s own hair works well, even as the hair loss progresses, but sooner or later, the comb-over starts to become obvious as the balding area enlarges so much that the hair can not cover it. Because the change occurs each and every day over years, the person who uses the comb-over doesn’t notice it. Even their wives don’t see it, nor do many of those in a close family. If the comb-over is really bad (I see them at the theaters all of the time), friends and family don’t want to touch the subject, so these poor men just don’t know how they look. This is a classic psychological term called “denial”. These men think hairs, and they are hairy, no matter what anyone says.

Norwood 6 and 7Alternatively, some men create bouffants, a puffed up hairdo which is made up by very long hair that is wrapped around the top of the head to look like a normal head of hair. Some of these bouffants are truly amazing and they have often fooled me when they came into the office. Most of these man are either Class 6 or 7 patients and they work the frontal hair, hair by hair, to stick to the upper part of the forehead and combing the hair from behind to a forward direction so that the actual hairline does not show. I remember one man who took it one step further — he cut his hair and let it settle on his bald scalp. I am not sure how it started, but when I saw him, he had a pile of loose hairs, held by the dirt and grime of Los Angeles, to the bald area of his scalp. It worked, at least for the top and crown of his head, but not for the front of his head. This poor man never washed his hair, because the hair would all go down the drain. He used a type of perfume to neutralize any odor from his hair, which actually smelled musty.

So styling, which works for slight hair loss and is very commonly used, is modified over and over again as the hair loss progresses. As over 50% of women over the age of 60 have significant hair loss, the use of puffing up styles, allow the appearance of more as their balding becomes worse. Just go to a retirement community and you will see what I mean. If you realize than almost 50% of men and women over 45 have hair loss, most of them are using styling tricks to make their hair look fuller. Hair thickeners, gels and special hydrating shampoos will increase the thickness of each hair shaft.

It should be clear to regular readers of this site that hair transplantation rarely brings back the hair to normal densities. So the same tricks that are used in those with thinning hair are used by those people who have had hair transplants. On very rare occasions, I have returned the transplanted area to an almost normal density, but that is more the exception to the rule than what I normally do. Many hair transplant doctors would like you to think that you really get your hair back, but that is not the case. I have selected four patient examples with estimates of the actual range of density that they have obtained from hair transplantation. The reason that one might get a higher density return is because the supply is more than adequate to address the balding area demand.

Patient #1 has returned about 80% of his original density at great cost to his donor supply, which has become a bit depleted. His hair is very fine, so more density was necessary for his to get his crew cut hair style.

 

Patient #2 uses a puffed up hair style to create the illusion of hair (he has less than 15% of his original density replaced and is a full Class 6 patterned balding patient).

 

Patient #3 is a full Class 6/7 balding pattern and combs his hair backward to cover the balding in the crown.

 

Styling is part of a hair transplant process which you and your doctor should discuss as part of his informed consent. It is a process that balding men, sooner or later will adopt if they want to look hairier.

Taking Viagra to Counteract Side Effects of Propecia? – Hair Loss Information – Balding Blog

Doctor if sexual dysfunction is a side effect of propecia,and if i stop propecia the balding process will resume,could take viagra counteract the sexual side effects of propecia,and allow to continue to take propecia? And if not,would minoxidil alone do the job? Thanks in advance.

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Good question. First, only about 1% of the male population get erectile dysfunction from Propecia. There is no contraindication for using Viagra while on Propecia. The two medications do not have any interaction and it is safe to take them together. In fact, I recommend the use of Viagra (Cialis or Levitra) to the patients who experience erectile problems. A man whose sex drive is reduced while on Propecia will often not be helped by Viagra, as this only impacts the strength of an erection. Most young men do not have a lack of sex drive or an erectile problem, but as they get older (e.g. 30% of men in their 30s have ED, 40% in their 40s, 50% in their 50s, etc.). As ED is often present in men (with denial), the addition of Propecia may make the problem worse. Still, again, it is relatively infrequent.

Can Concealers Such as Toppik or DermMatch Effect Finasteride? – Hair Loss Information by Dr. William Rassman

Hi dr Rassman! thanks a lot for this wonderful site. I am wondering ıf you see some hair loss signs in your son, what will you do FIRST to treat it? and also, have you ever used concealers such as toppik, dermmatch, couvre….? can they effect the working of finasteride? thanks a lot.

If my son had early miniaturization, I would immediately start him on Propecia. That is what I did with one of my three sons. The use of concealers should not impact finasteride.

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Do Men Have More DHT As They Age? – Hair Loss Information by Dr. William Rassman

I was wondering Testosterone levels are supposed to be highest when men are in their 20’s, yet for most men the effects of DHT are not seen until later. Do men have more DHT as they get older (past the 20’s), even though produce less testosterone? Do men develop more DHT receptor sites when older or produce more 5AR enzyme when older to convert testosterone to DHT? They don’t have these DHT receptor sites in the scalp when younger, just older? Like a cancer that just appears after so many cell divisions and the genes reach a certain point? LOL, well just wondering why men have more DHT (hormone) when older if produce more testosterone when younger, I’m sure a lot of other people would be interested in that information, Thank you very much for any info or sites that may have info!

You ask a very good and interesting question. You sound like you are just about to take a biochemistry exam. Unless I am mistaken, DHT levels will correspond with testosterone levels. Generally, less testosterone (an aging problem) should produce less DHT. The reason why you see balding men who are older (when testosterone levels are relatively lower than their younger years) is that it is likely a late expression of the genes that affect hair loss. On a counter note, most balding men will report that their hair loss began in their late teenage years (when their testosterone levels were the highest).

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