Hair Loss InformationWhat Does Auto-Cloning Mean? – Hair Loss Information – Balding Blog

Admittedly, I’m not too bright – It sounds like hair is plucked form the back of the head and transplanted in the scalp? Then the plucked hair grows back? Does this mean there would be no need to cut a strip from the back of the head and there would be an unlimited donor supply?

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Actually, your conclusion is right on. If this process becomes a standard treatment for hair loss, then the need for a traditional transplant would not be needed as long as you’re willing to go through a procedure that involves plucking many hairs and have them placed into another part of the scalp, one hair at a time. It takes patience, but the hope is that the donor supply is unlimited. This assumes, of course, that the hair that grows from the original plucked hair will regrow and cycle as it did when it was in the donor supply (where the plucked hair came from).

So that’s what we’re referring to when we mention the ACell product and auto-cloning. There are a lot of variables still unknown, which is why we’re going to be studying it.

Hair Loss InformationWould ACell Be Like Going Back to Old Plugs? – Hair Loss Information – Balding Blog

Can you explain how these ACell hair transplant procedures most likely will be performed?

In my mind, the strip option would be leave a scare too big for the ACell’s MatriStem product to heal/regenerate with out stitches , and If you take a strip of skin out, and stitch it together, there will not be alot of room for regenerating. A standard small FUE scar would be less time efficient and more costly for the customer. I guess, if donor supply is becoming unlimited, customers will demand higher density,more coverage and less conservative hairlines, which would make for more “mega session” type surgeries. As a 24 yr nw3 stable due to proscar, hair transplants never seemed like an option for me, just because of available donor hair – future balding, as I am pretty sure I will end up at Nw6 or 7 if science doesn’t beat genetics.

So If ACell’s MatriStem products turns out to be the standard, do you think we will go back to the old school butchering plug extractions? Since the sessions will be longer and more of them as well (I guess clients will ask for masterplans to have 10,000-20,000 or even 30,000 grafts! Instead of 3,000 – 7,000). And with the healing more forgiving, Would the ACell’s MatriStem product allow the surgeon to butcher the back of clients heads?

Your thoughts on the subject would be very interesting to read.

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This is still a very early stage of trials and development. New ways of doing old things will arise. If the new technology works as planned, it will certainly not be like the old days of the bulky hair plugs. It should not produce scarring, as there is no surgery here.

I’d prefer to not get into too much detail here at this time, so please follow our announcements to come. You can see all of our recent posts on this subject in the new ACell category.

More Info About NHI’s ACell Study – Hair Loss Information – Balding Blog

ACellI want to respond to some questions and comments I’ve received about our previous post about the ACell study we’re starting. The presentation at the ISHRS meeting was clear that the use of the ACell matrix with plucked hairs can stimulate growth. The process of doing this may not be as simple as it appears to be for many physicians.

First of all, the plucked hairs are usually a single hair with minimal tissue to protect it from harm when they are handled and/or exposed to the air during the transfer process. The surgeons who offer this have to be skilled to manage one-hair grafts without killing them. The application of the ACell Matrix has may nuances associated with it, so the doctors who “experiment” with this technique must build a process that works over and over again. It is also important to understand that the newly formed follicles will contain tissue from the donor area (the plucked hair) and tissue from the recipient area (the part of the follicle induced by the hair/ACell/tissue interaction). Since some of the follicle is derived the recipient area, we can’t be sure that it will cycle as a normal hair or even be totally permanent.

Over the years we have developed many processes that have led to many of today’s standards in hair transplantation, such as FUE, FUT, megasessions, and dense packing. We have consistently published our work in peer reviewed medical journals and have brought science to the world of clinical hair transplantation, advancing the standard of care over and over again. Our team (Dr. Jae Pak and myself in LA, Dr. Robert Bernstein and Dr. Eric Schweiger in NY) have put our heads together to build a process that, we believe, will afford our patients the best opportunity to benefit from the hair multiplication process and help the industry command the process better and with more certainty.

We are not of the belief that what we are doing with regard to hair multiplication is for everyone, or that everyone should rush into the process before the results of our work (and that of others) are completed. For select patients who are interested in participating in clinical trials or being treated outside the studies at this time, we would be happy to evaluate you to discuss this during a consultation. Remember, this process may not be for everyone at this time.

In the News – Unihair (Aderans) Hopes Hair Cloning Will Increase Sales – Hair Loss Information – Balding Blog

Snippet from the article:

Unihair of Japan, the world’s biggest wigmaker, is hoping for a big increase in sales through what might be regarded as the ultimate cutting-edge technology – a method to “grow” luxuriant displays of new hair on a person’s scalp.

The method uses cell-generation processes derived from pharmaceuticals research. “We see a tremendous number of possibilities [from the new process],” said Tadao Otsuki, Unihair’s chief executive. “It adds up to a fundamental shift in how the world can combat problems of baldness.”

With the help of the new techniques, based on ideas developed in the US and which are now undergoing clinical trials, Unihair is hoping to increase its annual sales roughly three-fold, from Y57.3bn ($706m) in the year to February 2010, to about Y150bn in 2017.

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Fingers crossedRead the full story from the Financial Times — Unihair gets a grip on baldness

There is a big difference between what we hope to achieve with using ACell in hair transplantation to multiply hairs in an ‘auto-cloning’ manner and what Unihair (formerly Aderans prior to September of this year) is trying to do with cloning hair outside of the head in a lab.

It’s in the best interest of patients that these technologies work, so I’m keeping my fingers crossed.

ACell Hair Multiplication Study at NHI – Hair Loss Information – Balding Blog

ACellLast week I wrote about the ACell presentation at the recent International Society for Hair Restoration Surgery (ISHRS) meeting that may have opened the possibility for a patient’s hair to be multiplied in his or her own scalp. ACell’s MatriStem has had some early success with growing hairs that were plucked and then placed into recipient sites on the patient’s scalp, and although this is a major breakthrough, significant work remains before this becomes a practical hair loss treatment.

For those that missed my post from last week, here is a little background —

    ACell, Inc. has developed and refined an Extracellular Matrix (ECM), a natural biological material derived from porcine (pig) tissue. When ACell’s MatriStem product is placed into a surgical site or wound, it is reabsorbed and replaced with new, more supple tissue, rather than a firm scar. The ECM stimulates the body’s own cells to form new tissue specific to that site. When applied to hairs plucked from elsewhere on the body, this is called “auto-cloning”, as new hairs are derived from the process.

We are currently studying the use of ACell for scalp hair multiplication (auto-cloning) as well as the facilitation of wound healing in follicular unit transplantation procedures. For those individuals interested in auto-cloning, we will be happy to see you in the office for a more in-depth discussion of the opportunity. Details will not be discussed over the phone but will be covered by the doctor during your consultation.

People interested in working with us in a study can participate at no cost, but because of the newness of the process, we will be selective as to which patients we accept. A limited number of patients who are not selected for a study may be eligible to obtain this procedure as well for a special fee. We will also be using ACell in the donor area of on our traditional strip surgery patients to promote better wound healing at no additional cost. Please call my office at 310-553-9113 to set up an appointment for a qualifying examination.

Live from ISHRS 2010 Meeting in Boston – ACell Discussion – Hair Loss Information – Balding Blog

Hi Doctor,

I am assuming you’re attending the ISHRS meeting and was hoping you could attend the ACell discussion to report your opinion on your blog. Here’s the press release that caught my eye: MatriStem in Hair Restoration at Annual Scientific Meeting

Thanks

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ISHRS 2010I’m actually in Boston at the International Society for Hair Restoration (ISHRS) Scientific Meeting, and wrote this on my little netbook to get you a timely response.

The ACell material is reportedly derived from Porcine urinary bladder. Here’s a good, short description of ACell’s product from another conference they attended: “MatriStem® devices are a naturally occurring, completely resorbable, acellular, extracellular matrix. Different collagens, bioactive components and intact basement membrane help surgical sites remodel by supporting the growth of new blood vessels, connective tissue and muscle.

At the ISHRS meeting, two doctors presented its use in plucked hairs. Hairs were plucked out of the beard or side hair and amongst these hairs the best ones were identified. The ACell was applied to the plucked hairs and then placed into recipient sites. Some of these hairs grew (less than 50%), but the good news is that supposedly the site where the hair was plucked also grew out a hair. The data is very sketchy and there is clearly no well identified process — no right way or wrong way to do this. But in theory, new hairs come from the process. If what was presented is accurate, then the dream of something for nothing (hairs that are essentially replicated) produces more hair than what was there prior to the procedure.

This MicroMatrix has experience of use in keloids, other types of wounds, and in the treatment of lacerations, ulcers of the skin (diabetic and vascular in origin), and burns. From what was presented, a great deal of interest was generated, but there is much research that needs to be done before it can or should be offered to the public. I suspect that the research will be on the fast track as many doctors saw the opportunity to make more hairs than they started with.

In the News – Hair Cloning Expected to Be the Future – Hair Loss Information – Balding Blog

Snippet from the article:

Cloning will represent a major advance in hair transplantation when it is ready for prime time. It remains elusive for now, but new clinical therapies — along with older standbys — are helping hair loss patients in the meantime, according to a leading specialist in hair transplantation.

One of the factors limiting hair transplantation is donor density. Individuals without good donor density can be less-than-ideal candidates for hair transplantation, notes Nicole Rogers, M.D., F.A.A.D., dermatologist and hair transplant surgeon and clinical professor, Tulane University, New Orleans. The potential for cloning leaves physicians hopeful for now.

“That would be the Holy Grail,” Dr. Rogers says. “It would be great if we could harvest a single hair from the back (of the head) and create thousands of copycat hairs from that. There is significant research ongoing in that area, but we are not there yet. It’s still going to be a while before it is ready for Food and Drug Administration approval.”

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Read the full text at Dermatology Times

Dermatology TimesI just wanted to post this to show that I’m not just some curmudgeon when it comes to advancements in hair cloning. I still get emails from some readers with an accusatory tone when it comes to my opinion on hair cloning, and I suppose they’d rather me post false hope instead of the actual truth. The article points out the same things I’ve been saying for years — hair cloning is not ready for prime time and although there are companies working on it, there’s no chance this will be ready for the public soon.

When hair cloning finally does become a reality, you can be sure that we’ll be writing about it here. Right now though, it’s still far too early to get overly excited.

Hair Loss InformationYou Can’t Compare Cloning Advances Today with Promises Made Decades Ago – Hair Loss Information – Balding Blog

Hey Doc. Thanks again for your blog. Last night I was pondering the future and was wondering whether or not you could help me with something that has been niggling away at me for a couple of weeks now.

Can you please give us a history on the failed ideas and companies that made promises for a hair loss cure 20 – 50 years ago. Just the ones that had any scientific merit would suffice, well of course the others might provide some good comic relief so its your call ;)

My own thoughts are as follows, food for thought?

It is my understanding that the failed promises of 50 years ago did not include stem cell research, regenerative medicine, and whatever modern approach to ‘hair cloning’, companies like Histogen and Aderans use today. They simply could not have had today’s recent scientific break through technology to back them up.

In which case what where the promises back in the day? Or were the doctors of 50 years ago merely just saying that ‘there will be a cure in 3-5 years’ to spread hope. Very kind of them.

What about Propecia people may say? I agree that Propecia has been around for a long time but that was an accidental find by researchers hunting out a cure for mens prostate problems. In other words exactly like your recent article on how researchers discovered they could change human cells from one type of cell to a skin cell complete with hair follicles. In that article you state why would they change their research. Well I’d say for exactly the same reason that Propecia did when they accidentally became a billion dollar company.

Today we see companies like Histogen, Aderans, and a few others that are actually showing positive results and backing them up with photographs. If they are legitimate images then the future looks promising. By promising who couldn’t do with just a little more transplant hair – maybe if we’re lucky Histogen will be able to simply increase the yield in our donor areas. That alone would be fantastic.

50 years ago things were different. Nobody had heard of, or at least practised, things like Nano Technology or Stem Cell research. I wasn’t even born. We didn’t have cellphones and the US military were not growing peoples limbs back!

With all the modern changes going on I’m just not sure if it is helpful to compare today’s tech with the tech of 50 years ago. All I hear is that 20-50 years ago they promised us that there will be a cure in 3-5 years. Well what were they promising – I’d love to know :)

Yours with love to all my balding brethren.

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In regards to the accidental stem cell follicle discovery, I suppose it depends on the priorities of the researchers on whether they want to switch gears or start another study. It could be that the news of their accidental discovery was made public to garner interest in the project and to take on investors. I’m just guessing here, though.

Propecia is made by Merck, a large pharmaceutical company that didn’t become a billion dollar company by accident and makes more medication than just Propecia… but I see what you’re getting at and agree that money talks.

I do thank you for the input, but I am not a cloning expert nor a historian on cloning of hair. I could spend weeks or more researching the paths taken in hair loss cures over the past 50 years, and while it would likely make for interesting reading, it is beyond my scope at this time. What I do know is that doctors have been stating and vaguely projecting that cloning of hair is on the horizon within most of our lifetimes. I certainly hope that is the case, but the timelines have been moving with such frequency that it’s easy for people to grow skeptical until there’s an actual working model in place.

Hair Loss InformationDr Farjo Discusses the ICX-TRC Cell Therapy Clinical Trial – Hair Loss Information – Balding Blog

The following post is by UK-based physician Dr. Bessam Farjo:


Written by:
Dr Bessam Farjo, United Kingdom
Dr Bessam Farjo
United Kingdom

I’m often asked about the ICX-TRC Cell Therapy Human Clinical Trial and whether or not it was successful. For those of you who don’t know, the trial was (in very simple terms) the development of a therapy whereby cells are sourced from an individual, multiplied, and then returned to that same individual. Take a look at the Farjo website for a more detailed account.

For anyone who has experienced any form of hair loss, the idea that your own existing hair follicles can be multiplied and re-implanted is a huge breakthrough.

Initial results were very encouraging, with an excellent percentage success rate seen within the test areas of the trial subjects.

Unfortunately, whilst the ICX-TRC trial results appeared positive, another unrelated Intercytex project was having less success. As a result of this and Intercytex being listed on the stock market (to make a long story short) the project’s funding was cut, putting an end to the activity – for the time being. The global credit crunch exacerbated matters further.

In 2010, the different divisions of the company were broken down and sold off to different interested parties. The ICX-TRC trial was acquired by Aderans Research (ARI) in the USA, who are continuing to do trials on this subject.

Cell therapy is still an exciting and promising area for the future; however it has proved to be a complicated study that still holds lots of unanswered questions. We’re still very much committed to the concept as well as other exciting areas, and hope to have the opportunity to discover the answers to some of these questions soon – watch this space!

Learn more about the author of this article, Dr. Bessam Farjo, on his BaldingBlog profile or at his website.

Is Hair Cloning a Viable Option in My Lifetime? – Hair Loss Information – Balding Blog

Hi Doctor,

I was speaking with my grandfather the other day about our family history concerning hairloss. He’s been at about a 6 on the Norwood Scale for as long as I can remember. I am 19 years old and I’m starting to see the first signs of recession at the temples. He mentioned something he heard about hair cloning. What is your opinion on the technique, and do you think it will be a viable alternative to finasteride and hair transplantation in the near future? Thanks for your time.

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We have written about hair cloning (or lack thereof) many times before. There are groups that are working on it, but people have been flocking to message boards to show their excitement prematurely. Hair cloning is in the very early stages, and while there have been some promising advances it is still far too early to suggest this is a winner. There are still many more years of testing to go.

I would like to hope that hair cloning will be a reality in our lifetime, but I really do not have a guess as to when.