Since Hair Cloning Hasn’t Happened By Now, Are Statements Made in Years Past Considered Unethical? – Hair Loss Information – Balding Blog

Several years ago, Bosley Medical Director and Aderans Executive Vice President Ken Washenik, M.D. declared with supreme confidence that the Aderans hair- multiplication procedure would be available to the public by 2007. As we know, this has not happened.

Simply put, although I fully appreciate that medical science is far from exact, it seems plain to me that these statements were made with the understanding that the predicted timelines were utter fantasy. Thus, I have little choice but to conclude that the statements were made with an eye toward self-interest, to wit, raising the firm’s profile and ultimately soliciting additional investment capital.

My question is this: If a doctor or a medical practice deliberately or recklessly declares the imminence of a cure when it knows or should know that the statement is materially false, should that be considered a breach of medical ethics?

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AderansCome on now, I’m sure that he believed that the solution would be at hand in 5 years or so. If a weather man predicted a sunny day tomorrow, and tomorrow came with heavy rain, would you call that unethical behavior? There are limits as to the predictability of the future. In our capitalistic society, the entrepreneur believes that his inventions will work, will take less time than it really takes to develop a marketable product, and he often puts his hard earned savings into that business. Not all businesses succeed, not all ideas work and when they do not, it is the entrepreneur that usually pays the price for it. I am sure that Dr. Washenik was humbled by his failure to predict the timeline for cloning correctly. I personally commend him and Aderans for their persistence in working on the problem.

Is Follica the Same as Hair Cloning? – Hair Loss Information – Balding Blog

Hey Dr,

Great blog, keep it up. I’ve read about seemingly cures to hairloss – follica, haircloning etc.

Just to make things clear – Is follica’s approach also known as hair cloning, or is it completely different? I just want to distinguish between the two.

I ask because you say that haircloning will probably not available for another decade, or more. And am wondering if this applies to follica’s research.

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The difference relates to the mechanism of action for Follica which is distinctly different from hair cloning. A Follica press release states, “By studying wound healing on a molecular level, Dr. George Cotsarelis and colleagues discovered that the skin has the ability to revert to a more primitive or ’embryonic’ state as stem cells migrate to the affected area, thereby achieving a regenerative capacity not previously appreciated to occur in adults.” It is this capacity that the research for Follica is based on.

Simply put, cloning requires that replica cells are created from an original cell, while the approach from Follica is to simulate the repair process, gaining more control over it to produce hair. The same press release goes on to say, “The researchers were able to control the regenerative response, including the extent of new hair follicle formation, by manipulating genetic pathways during this ’embryonic window’ when new follicles formed.

The Doctor at the Aderans Interview Said Cloning Would Be Available in 5 Years – Hair Loss Information – Balding Blog

Dear Dr. Rassman,

I am a 29 year old male. I became aware of thinning in my crown area in April of ’09, and got on Propecia at the beginning of May. I volunteered for the Aderan’s phase II hair/cell replication study, but was told I had too much hair to be a subject. The Dr. at the clinic where I was interviewed said the cloning procedure would be available in about 5 years.You state that you see the cloning procedure as a decade off, so from the information you’ve gotten at this recent convention, is it reasonable to imagine that in my late thirties, around 2019 or so, that I can get hair restoration through a cloning procedure? And in the next few years, do you see a better drug, like an FDA approved version of Dutasteride coming to market?

Thank you for you time

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The folks at Aderans predicted the cloning solution would be available in 5 years… and that was 5 years ago. So by that timeline, it should be here now… yet here we are, wondering where it is. I probed that question to those who are knowledgeable and found that no one really expects a cloning solution in 5 years. Perhaps ten years… and maybe more.

Dutasteride is already FDA approved to treat the prostate, but I’d like to think it’ll be available for treating hair loss at some point down the line, once any other studies are concluded and safety can be assured. It’s not up to me, and I’ve got my reservations about the medication already. There are no other new hair loss drugs like dutasteride that I know of coming in the next 5 year horizon. It takes years to clear it through the FDA so we will have plenty of notice when the process starts for a new medication.

Hair Loss InformationI’m Just Taking Medication Until Cloning is Ready – Hair Loss Information – Balding Blog

I have been losing my hair since i was about 17 and a half and i have found it deeply depressing and i am sick of the smell of hairspray! I was just wanting some helpful advice …

I have been taking Propecia for about 4 months and i am yet to notice any results and i am beginning to consider but as i am only 18 i will probably be denied such treatment. I just want something to tide me over until hair cloning is made public. Do you have any idea when this may be?

Any Advice you have i would be very grateful to receive.

Yours sincerely

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I just got back from the annual ISHRS hair doctor convention (this year was in Amersterdam), and that very same question about cloning was asked to the experts who where on a panel that I chaired. The answer is that there is no cloning in the near future. I’ll write more about the ISHRS meeting in a future post this week.

My honest opinion is that cloning is still a decade away from being available to the public. They’re making progress, but even the clinical trials seem not to be working as hoped. If you follow message boards, some believers will tell you to give it another year or two… but that’s a moving timeline. I’ve been reading it’ll be available in “5-10 years” for at least the past decade. If you believe that someone has the answer, please let me know as it might just be good marketing hype.

You won’t see results in just 4 months of Propecia use, but stick with it. The most common question I get from 18 year olds on Propecia is about hair loss in the hairline. I don’t know what your hair loss is like, but keep in mind that full regrowth isn’t a benefit of the medication that you should be expecting. Just stopping the hair loss where it’s at is benefit enough. The peak benefits of Propecia takes 2 years and the gain in the second year slowly appears.

Wnt Treatments Lead to Cancer? – Hair Loss Information – Balding Blog

Dr Rassman, Lately i have heard talk of the possiblity that WNT/regenerative treatments may lead to cancer. Could you please clarify this topic and offer any opinions? thank you

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It seems like Wnt stimulated follicular neogenesis is hot area of biotech now (Histogen, Follica), but it is something that I do not understand enough to speak with authority. This is straight from Wikipedia, which is sourced from a July 2005 article in the scientific journal Nature: “The Wnt signaling pathway describes a complex network of proteins most well known for their roles in embryogenesis and cancer, but also involved in normal physiological processes in adult animals.

I do not think I can clarify much more for you aside from what is stated. From the little research I’ve done, Wnt signaling has been associated with cancer in some tissues. How that relates to what they’re doing with hair, I haven’t a clue.

Hair Loss InformationHair Multiplication at Hair Science International? – Hair Loss Information – Balding Blog

Hi there,

My question is, have you heard of ‘Hair Science International’? I went to see them last week here in Melbourne Australia and they say they can take a sample of my hair from the back and multiply up to 70,000 hairs in a lab and transplant however much I need back into my head and it will stay for ever. I’ve seen some of the results and in terms of coverage it’s great. But I don’t know how well this technology works in recreating the natural hairline and what kind of survival rate it averages.

Should I avoid them or is it worth investigating them more? Any advice would be much appreciated.

Thankyou.

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If this company told you they could take a hair from the back of your head and multiply it to 70,000 hairs, then transplant it as needed (and their site says without surgery?)… then they’re either from the future or someone was giving you a line of bull.

My guess based on the photos on their site is that they sell fancy wigs and laser treatments. That’s the only way I could explain how they can call this “hair multiplication” but then in the same sentence say that it is non-surgical. Even then, they’re using “hair multiplication” in a completely misleading way. The technology doesn’t exist in the way you described. So either you misunderstood what they told you or they’re misrepresenting themselves. It’s not cloning or multiplication.

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Post updated Jan 5, 2011:
I would be happy to read and review evidence that supports any claims about growing 70,000 hairs in a lab for transplantation back into the scalp, but until that time I’ve closed the ability to comment on this post due to complaints.

In the News – Follica Gets a New CEO – Hair Loss Information by Dr. William Rassman

From the article:

Follica, the Boston-area startup out to bring a scientific approach to helping hair-loss sufferers re-grow their locks, is preparing for some new growth of its own. The firm, run since its late 2006 inception by founding CEO Daphne Zohar of Boston’s PureTech Ventures, announced today the hiring of a new president and CEO, William Ju, a biopharmaceutical veteran with experience in an array of therapeutic arenas, including dermatology (he is a board certified dermatologist). The selection of Ju seems to position the firm to move out of the purely research-focused stage and closer to becoming a drug development company.

Read the full text at Xconomy.com

We last heard some activity from the Follica folks last summer, when they got an extra $11 million round of funding in addition to the initial $5.5 million they received in early 2008. Now they’ve got a new CEO. What does it all mean? One could only speculate at this point…

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What Are Dr Rassman’s Guesses About Future Hair Loss Treatments? – Hair Loss Information by Dr. William Rassman

Hello doctor,

I am a 28 yr old male. My hair drastically started reducing its density starting two years ago. It is true that you notice you are losing hair when you lose almost half of it. I now keep it shaved and when hair grows out you can tell very well that my hair is much thinner starting from the crown down to the top/front of my head.

I have gone through a substantial amount of literature regarding baldness (you have a very well informed website btw), and although I am very excited about the new age treatments like hair multiplication and cloning (endless supply of donor hair), I am quite aware that all this is at its inception with much more work to be done.

My question to you is this. Since you are a man of science, and you have witnessed it advance in the area of treating baldness since the last two decades, do you believe, taking all the current advancements into consideration, that there will be a breakthrough in 10-15 years? Of course, I know that you cannot be prophetic in the matter but simply what your thoughts are. Because your guess will certainly be better than mine.

FutureI am optimistic of a hair loss breakthrough in 10 to 15 years, but if you asked someone a decade ago, they likely would’ve said the same thing back then. A lot of people are getting tired of hearing the same old “cure in the next 10 years” talk, but I will continue to be optimistic even if that timeframe comes and goes. Baldness isn’t a life threatening illness, but it is a billion dollar business… so as long as people continue to lose hair and there’s a market to end that loss, there will be companies clamoring to come up with the next great treatment. As technology evolves, the concepts that some people came up with that were once considered ludicrous can finally start to become within reality’s reach. Don’t get me wrong — there are still plenty of ridiculous ideas that will never work to treat hair loss. We’ll just have to wait and see and try not to buy into the hype too much, because there’s been far too many letdowns over the years (like that flying car we’ve all been promised).

With respect to the current gold standard in hair restoration technology, hair transplant procedures have come a long way in the last 10-15 years where most doctors are performing the individual hair follicle transplants or follicular unit transplants that give wonderful results with issues that are virtually undetectable.

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Dr. Farjo Answers More Intercytex Questions – Balding Blog

Thank you very much for answering our questions and for having this site. Thank you Dr. Farjo for joining. These questions are for Dr. Farjo re: hair multiplication/intercytex study:

  1. Is Intercytex going to phase 3 trials with the procedure they currently have?
  2. Is the current product marketable given the current results, if it does go into phase 3? (It sounds like it is not, but that it created an enterance into another idea that may be marketable)
  3. How long do you think it will be before a marketable product exists?
  4. You mention that further studies are planned. When do you think this new Photo-hair technology will be tested on humans?
  5. Will Intercytex be doing these studies? It sounds like they are waiting for someone else to buy them out. If not Intercytex, who will be doing these studies?
  6. Intercytex has mentioned they have given Bosley the option of purchasing them or parterning. Bosley has their own theory on how to make this work, so why would Bosley buy them? (Speculating of course)
  7. Who else besides Intercytex and Bosley/Aderans seems to be doing hair multiplication testing/research?

Thank you for any or all all answers to the above questions.

The following response is by UK-based physician Dr. Bessam Farjo:


Response by:
Dr Bessam Farjo, United Kingdom
Dr Bessam Farjo
United Kingdom

  1. A decision has not been made yet on timing. One reason is that we are still waiting on the analysis of the global photos concerning the larger of the injected areas. A second reason is the more promising finding of growing hairs out of the multiplied cells in the lab in the mouse, which will hopefully lead to a new clinical trial. Finally there are financial restrictions at the moment due to the global economic situation that is affecting most biotech companies.
  2. See Q1. A product goes into market only after successful phase III.
  3. Due to all what I mentioned it would be foolish of me to predict that with any accuracy.
  4. A clinical trial should take place once the lab studies on human hair produce results reliably and predictably. We’re not at that point yet.
  5. No, that is not the case. They said they are looking for funding from outside the company for this project. Given the funds, Intercytex will continue with these studies.
  6. Bosley has an option to market Intercytex’s product should they succeed ahead of Bosley (or more accurately Aderans). I take this opportunity to confirm that I am neither a director nor a shareholder with Intercytex plc.
  7. I am not aware of anyone else.

You’re very welcome.

Learn more about the author of this article, Dr. Bessam Farjo, on his BaldingBlog profile or at his website.




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Hair Loss InformationAderans, Phase 2 – Hair Loss Information – Balding Blog

Dr Rassman, What are your feelings concerning Aderans Phase II trial that is commencing this month?

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I am sure I will hear more about it in detail at this year’s ISHRS conference in July. I will keep you posted, but I have no knowledge of the details in the approach that they are using.

I did find this press release they sent out to announce the start of their phase 2 clinical study. In the press release, it reveals that Phase 2 “is being conducted in six U.S. cities: Atlanta, Boston, New York, Raleigh, Houston, and Washington DC”… but that’s really the gist of it. I don’t know how many are in the trial or how long it’ll be going on for.