Did Propecia Screw With My Hormones? – Hair Loss Information by Dr. William Rassman

Hi,

I’m 23 years old and a male. I was on propecia, when I was uncomfortable about my hair situation, though my doctor suggested it wasn’t a necessity. I have more thinning in the temple region (perhaps maturing hairline but I have a large forehead). After awhile, I decided it was not worth it to be on this pill forever and I hadn’t noticed a significant change in my hair. So, I decided to stop taking it roughly 7 months after I started. I have noticed lately some shedding (not of miniaturized hairs, but regular kind). I normally shed during the winter anyway, but I’m wondering whether I should be concerned that Propecia has screwed with my hormones, or I should expect hair growth to resume?

ScrewIt seems like you are describing a phenomenon called “catch-up” hair loss after stopping Propecia.

Patients sometimes do not understand that having no change is good, as it indicates stability. You may not notice new hair growing with Propecia, but you are also not losing more hair. Once you stop the medication after a few months, all the positive (silent) benefits of Propecia will reveal themselves, as the hairs the drug protected from falling out will be lost.

I do not believe Propecia “screwed” with your hormones. Instead, you likely have genetic hair loss and Propecia (while you were taking it) was keeping your hormones (DHT) from causing hair loss.

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Injections to Dissolve Fat Tissue in Breasts After Propecia? – Balding Blog

Body changes, Should I start with finasteride?

Hello Doc. All over the web I’ve read about side effects that can occur with finasteride. Despite a lot of trash talk (..and positive comments..)I find this product worth a try.

I’m 24 years old male and I start to notice more hair on my body and beard – but my head hair is thinning and hairline slightly receding with temples as proof.

  1. Do you think I should start finasteride despite the fact that my body seems to still have some more missions to complete?
  2. I also notice more fat tissue in my chest region, which makes me wonder if finasteride is more likely to cause male-boobs in users already having small ones to begin with?
  3. I read about certain injections which can dissolve fat, if large male-boobs do develope, could such injections be helpful?
  1. This is a forum for general questions. I do not give personal medical advice. I cannot tell you if you should start a medication without an examination or history. Sorry.
  2. While finasteride may cause enlargement of breast tissue or tenderness, the risks are 1 in 300 or less. Again, I do not have the luxury of a examination so I cannot tell you what your risks are just because you describe having more “fat tissue” on your chest. Your fat could be dietary, and finasteride (when it causes breast tissue) is usually in the glands just below the nipple and not the type of fat you build up on your abdomen. Are you over-weight with lots of fat everywhere, including your chest? Or are you thin with just an abundance of fat on your chest? Did you have ‘man-boobs’ prior to starting Propecia? Either way, there really is no way to tell without going into it further.
  3. There are no injections that I am aware of which have been proven to dissolve fat in the human body. That would be too easy. There is an emerging field of mesotherapy which claims fat dissolving capability (see Lipo-dissolve, but the proof is lacking from what I’ve read and much of it seems like hype. There are machines that compress your fat that claim fat reversal. I will admit ignorance in what, if any, ’science’ is reported in mesotherapy and in many of the other modalities being offered.

More on this Lipo-dissolve treatment can be found at the Washington Post. More on mesotherapy can be found at Wikipedia.




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A Big Batch of Rogaine Foam Questions – Balding Blog

Hello Doctor,

I’m male, 37, 6,1, 180lbs, don’t take any medication and my hair is about 1.5 – 2 inches long and sometime 3. I have male balding on the top and receding hairline. In the past I have had thick and lots of hair, now the top is thinning to a point were I get sun burns and makes me cold in the winder. This is the part that I really don’t like as I hate wearing something on my head.

My question is, when looking at Rogaine, which product is best for me? Here’s my thinking, some with questions:

  1. It is important that the solution gets in contact with the scalp, so with “longer” hair will the foam product be as effective?
  2. Is volume and length of hair need to be considered when choosing product?
  3. With the foam product how do you know one is using the right amount?
  4. There has been remarks about the smell of the foam, are there scent free versions [coming]?
  5. How can one test the product without buying a full size?
  6. Is there a difference between the different brands, besides price?
  7. Is there a generic foam vs. Rogaine?

Thanks.

Rogaine Foam

  1. Yes, the Rogaine (minoxidil) needs to be in contact with the scalp in order to be effective. Hair length doesn’t matter, but volume of hair could play a role in getting the medication to reach your scalp. Just be diligent and move your hair around to get the minoxidil onto the scalp.
  2. See answer above.
  3. I would think there is some instructions on the packaging. The Rogaine Foam site says “the total amount of foam applied should not exceed half a capful.” For the liquid, the recommended dose of the Rogaine 5% topical applied twice daily.
  4. I have no idea if they’re making a scent-free version.
  5. I don’t know if Johnson & Johnson (makers of Rogaine) offer a free sample of the foam. Drugstore.com sells it at $22.79 for 1 month or $42.49 for 3 month supplies. The best price depends on your own research.
  6. The foam is reported to have better absorption than the liquid formulation, but I do not believe it is a significant advantage to achieve a drastic difference. Generally speaking, a generic minoxidil 5% solution would be the least expensive (most bang for your buck).
  7. To my knowledge, there is no generic version of Rogaine Foam.

More information can be found on the Rogaine Foam site. Remember, before starting any medication you should see a doctor (a hair transplant doctor is fine) for a good initial evaluation. You may also be a candidate for finasteride (Propecia).




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Hair Loss InformationDostinex (Cabergoline) and Propecia – Hair Loss Information – Balding Blog

Dear Dr. Rassman,

I’m a 28 year old male. About 6 months ago I was diagnosed with a rare pituitary condition called hyperprolactinemia. This disorder is genetic in my family, and mine is a very mild case. The treatment is a single half-dose of cabergoline (marketing name Dostinex) taken once a week.

Male pattern baldness also runs in my family and I’m starting to show thinning on the crown of my head. My dermatologist suggested I try the propecia/rogaine route. Since propecia affects the endocrine system I am a bit reluctant to take it without knowing more about possible side effects or interaction with the cabergoline. I don’t think it should and my dermatologist said she wasn’t aware of anything and I haven’t found anything about it on the web, but I wanted to get another opinion before I started propecia. I also read online that minoxidil from rogaine may have a side effect of increasing prolactin – the condition I have too much of. Do you know of any cases like this? If so, should I reconsider starting propecia, rogaine, or both?

Thanks!

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DostinexAt this point, it is very difficult to accurately assess the cause of your thinning hair. As far as I know, cabergoline does not have hair loss listed as a potential side effect, however, this does not mean that this drug can not cause this in you. Also, certain diseases / stresses to the body have also been known to cause hair loss. Lastly, as you have mentioned, male pattern baldness could be the cause of your thinning hair. You definitely need a miniaturization study to determine the extent and locations of most of your hair loss (i.e. does it correspond to MPB?).

There have been reports that minoxidil may be related to the development of hyperprolactinemia, definitely something you don’t need more of (see Drugs.com – Interactions between cabergoline and Minoxidil). The main point here should be that before you start any medication, whether it be Propecia or Rogaine, you should have a coordinated discussion between your physician that is treating you for the hyperprolactinemia and your dermatologist. To answer your question though, I haven’t read about Propecia (finasteride) and cabergoline interactions, but again, please discuss this with your prescribing physician.

If I Restart Finasteride After Stopping for 6 Months, Will Side Effects Occur Again? – Hair Loss Information by Dr. William Rassman

I have taken finasteride for about 18 months. after noticing a decrease in semen quantity (by about 40%) i stopped taking it for about 6 months. After stopping it. i have lost much more hair than what i had before starting the medecine. I can now almost see a big bald patch on the crown. I am thinking of restarting the medication. I would like to know if i will get any more side effects if i restart taking finasteride, i.e will my semen quantity reduce even further than what it has reduced earlier? or could i get any other side effects now considering that i had tolerated finasteride quite well earlier??

Your experience with finasteride and your semen quantity are probably the most cost common side effects reported. If you restart the finasteride, it will probably happen again. Despite the reduced quantity, you should be alright with fertility.

The really bad news is that you experienced “catch up” hair loss when you stopped taking the drug and that will not likely reverse, retaining much of the balding that you developed over the past 6 months. Your doctor should have told you about this, as I stress with my patients that stopping the drug will have the hair loss problems you experienced.

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Finasteride Lotion? – Balding Blog

I don’t think topical finasteride is regularly available at a pharmacy, but there’s a doctor that I’ve seen offering it. Why doesn’t Merck offer this and is it as good as the pill?

According to the website of one doctor that sells it, “Topically applied finasteride is reserved for use by those who wish to block only 5-10% of the DHT activity in the scalp, which is a lower level than typically achieved from ingesting tablets.” So why would you want to use a messy cream on your scalp and not block as much DHT as a single daily pill can?

If it doesn’t work as well as the 1mg finasteride pill in treating hair loss (if it works at all), this is probably why Merck doesn’t offer it. I really don’t know what Merck’s reasons are, but I doubt that there is real data to support the doctor’s declaration and I would insist on seeing where the “block only 5-10% of the DHT activity in the scalp” comes from. I am skeptical and I wouldn’t have a way to validate such claims.

Note: Bottle is for illustration purposes.




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Hair Loss After Taking Prednisone for a Week? – Hair Loss Information by Dr. William Rassman

My son is 31 – he took prednisone for 7 days. He experienced hair loss which never got better only worse. Could this medication, for such a short time, trigger this.?? He blames himself and is very depressed. I am so concerned not only about his hair loss but on how down on himself he is. Thanking you in advance.

I highly doubt a very short course of a medication such a prednisone would cause hair loss, although it is possible. Actually, we routinely prescribe prednisone to our hair transplant patients after surgery to reduce inflammation and swelling. Your son may have a component of genetic male pattern hair loss and needs to be examined. He should get his hair mapped out for miniaturization to see if he has genetic hair loss.

Juvista for Healing Hair Transplant Scarring? – Hair Loss Information – Balding Blog

I know this is years down the line, but when Juvista comes out, do you think that Juvista combined with tricho closure on HT scars (either after the process or in a revision) will allow men to cut their hair down to a 1 grade or even to the skin without the scar being too obvious? I know your response would be conjecture at this point, but it would be interesting to get your thoughts.

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RenovoThe scarring may be reduced, giving it a better ability to blend in (without being hyper- or hypo-pigmented or raised), but the hair will not grow on the scar. Scarring is very individualized. Even under the worst case scenario without a trichophytic closure, some people heal great and are able to cut their hair really short without visible scarring in the donor area. How well you scar is also a genetic factor (much like hair loss) and there is only so much you can do.

If Juvista does as it sets out to (eliminate scarring with a simple injection at incision site), it could be great for a percentage of those that it works for, but the drug just failed in its most recent clinical trial. Read Renovo, Shire Developing Anti-Scar Drug and Bad news on drug rocks Renovo for more.

So, the short answer to your question is… probably not.

Can You Dismiss Propecia Information on the Web? – Hair Loss Information – Balding Blog

Dear Dr. Rassman,

I have heard from people on the Internet, especially from the following two websites, that the sexual side effects of Propecia can be permanent, along with many others. Can you dismiss all the information on these websites?

propeciasideeffects.com and propeciahelp.com

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MegaphoneAnyone can write and publish anything on the Internet. You can you find contrary evidence to those sites you listed at Propecia.com. I can’t dismiss everything on these anti-Propecia/finasteride websites, because I simply don’t have time to go through every post made there. I’m sure some of the claims made there are based in fact and might have some validity — and those have more than likely been addressed here before (search for “Propecia side effects”). I’m also sure that much of the info on those sites is created by people that have no medical background and simply write what they believe to be true based on FUD (fear, uncertainty, and doubt).

The people that speak the loudest are usually the people that want their complaints to be heard. In other words, you don’t necessarily see a lot of people visiting message boards just to tell others that Propecia works great for them, but you certainly will see the unsatisfied few going to every website they can find to make their opinions known. When doing your research online, try to find out if you’re getting information from fact-based sources. Are these other sites just shills for the various snake oil products on the market today? What better reason to shoot down a proven treatment like Propecia than to promote your non-proven treatment that sells for double the price. I’m not saying that this is 100% the case, but anything is possible. Take BaldingBlog (this very site), for example — I’m a hair transplant surgeon, yet I’m not trying to “sell” people on hair transplantation procedures. I write a lot about Propecia because I get asked a lot about Propecia, and because I’ve seen first hand what this medication can do to treat hair loss. I don’t want to see anyone go through an unnecessary surgery when a simple daily pill could be the answer to their problem. I, along with the other doctors that write here, are just trying to help.

It seems what you really want is a doctor’s reassurance. Although I am a doctor, I am not your doctor… and you need to discuss these concerns with your doctor. You may not even be a candidate for Propecia.

I’m Missing the Connection Between DHT Reduction and Muscle Gain – Hair Loss Information by Dr. William Rassman

Doc,

I’m confused! We all know that finasteride reduces the amount of DHT in a man. This hormone is known to be the cause of secondary male characteristics, like hair growth and muscle development. So with reduced DHT levels, it should be HARDER to gain muscle, right.

Then how come in many of your previous posts you mention that taking finasteride makes it easier to build muscle since it increases testosterone levels by almost 20%? Granted testosterone levels increase since more of it doesn’t convert to DHT, but DHT, which is more responsible for muscle growth than testosterone, decreases!

How do you explain this?

I’m not seeing the connection here.

To clear any confusion, DHT blockage with Propecia may give you a small transient increase (not permanent or persistent) in testosterone levels, reported as high as 15%. These minor changes in hormones will not likely affect muscle mass (gain/loss) and are not long term.

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