What Is Retin-A? – Hair Loss Information – Balding Blog

Hello Dr. Rassman,
My question is not related to hair loss, but i figured you might know sth about it…What exactly is Retin A and how does it work? Does it come only as a facial cream or it can be taken orally as well? Does it cause vascularization when applied topically and why…as far as i know it stimulates collagen production, so capillaries should become less visible as skin fat increases…and one last question, my boyfriend is balding due to stress, what should we do? I would very much appreciate your answer/s. Thank you for your time

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Retin-A (tretinoin) is the acid derivative of retinol, vitamin A. For much more on this, please see SFSU: Student Health Services.

As Retin-A is applied to the skin and can produce burns to the skin. It is believed that a light burn will make the skin more able to absorb other medications (like minoxidil for hair loss), because increased vasculatiry is induced by the burn. Because it creates an injury to the skin, the entire injury process induces the body to repair it. The skin irritation could be a problem and is a problem for many users. The formation of new collagen is part of the process of repair and replacement as the body regenerates the damage caused by the acid.

With regard to your boyfriend, stress does accelerate hair loss. I hope you love him enough to reduce his stress so that he remains young looking and hairy longer.

How Would New Products for Hair Loss Work? – Hair Loss Information by Dr. William Rassman

Dr. R,

First off i want to say what a great site you have created. With all the nonsense out there on the internet, your site differentiates itself as being very informative and a trusted source for MPB.

A recent post said you were aware of two new drugs that are in the works to combat MPB. I understand there is a confidentiality issue, but is there any insight you can give as to how the product works and a possible viable timeline? I am aware of the length of drug approval from the FDA (5-10 years is your estimation) but a new product has not been released since 1997. Nearly a decade later and there doesn’t seem to be any progress which concerns me greatly. I am sure these drug manufacturers are aware of the multi billion dollar market there is yearly in the fight against MPB. If for nothing more than to make money, shouldn’t these companies be attacking the market as aggressively as possible? Those are just a few thoughts. Please get back.

Regards

The answers to your questions are almost impossible for me to relate them to you. On one of the drugs, the effect was found as a side effect of its use for treating another disease. Once they found that the same medication grew hair, they move it into a topical and speculated on mechanisms of action (looking for the science). One of the drugs is already in a clinical trial in another country and early indications have shown great results. The researchers told me that there were a few hundred people put into a double blind study and although they did not know who was on the topical medication and who was on the placebo, they did note that half of the people who were coming back for hair counts had good hair growth while others had none. They assumed (probably correctly) that what they were looking at was a remarkably strong hair growing medication. Until the study is complete, we will not know for sure, but the entire science will have to be understood and toxicology studies will have to be in hand in thousands of patients before the United States FDA will allow the drug come to market. Sorry, that is all I can say. Coming to market: A few years at the least, I would suspect.

It is interesting that minoxidil was first used as a medication for high blood pressure. It worked poorly and without consistency for blood pressure control but did grow hair on many men and women who took it systemically. As the drug already had some safety and other toxicology data, the move to a topical for hair loss was a bit easier. Propecia was originally used for men who had urination problems, but when taken for the prostate, some men grew hair. Again, another discovery by serendipity. Could you imagine what we would get if we found out about drugs by intent rather than serendipity?

Should I Take Breaks Between Minoxidil Treatments? – Hair Loss Information by Dr. William Rassman

Dear Dr Rassman,

Thank you for this informative blog and your dedication to answering our balding questions.

My question is regarding rogaine or minoxidil and its effects after you have a break after several years of treatment. I for one am 25 and have used minoxidil 5% since I was around 22. My barber here in New York told me that for Minoxidil not to lose its long term effect it is good to have a break after a few years and then go back on it again so to keep its effectiveness. Is this true?

I for one listened to his advice and stopped using minoxidil 5% for three months and I could see an increase in hair fall out after two months specially in the templar areas where I had gained a lot of new growth. Now my second and more important question is will I once again benefit from using the minoxidil again? I went on minoxidil about 6 weeks ago again but havent seen any results yet.

so two questions:
1) Is it good to have breaks in minoxidil treatment?
2) Will the effects of the minoxidil come back after restarting the treatment?

Breaks in the use of minoxidil are disasterous, as you have already seen. So the answer to your first question is unequivocally, “no”. The hair may come back if your ‘rest’ period is under 2-3 months. Read elsewhere on this blog about Propecia and its appropriateness in young men losing their hair. Get a diagnosis and proper treatment.

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My Physician Says Rogaine Works Better Than Propecia – Hair Loss Information – Balding Blog

My Primary care physician recently sent me this statement
“propecia has side effects and so we try to avoid it. rogaine actually works better.”

I am a 21 year old male that has started balding in the last few months. In your experience have you found that Rogaine works better than Propecia? I did research on the internet that Rogaine does not have very good long term success because the hair follicle eventually dies, and Rogaine is thus rendered ineffective. Also, There is no bald men on my mothers side of the family, but there is on my fathers. But nobody on his side of the family went bald until around till their late 20’s or early 30’s 30’s. He said he started to bald at the earliest in his family. He was 29. Do you think it is unusual that I would start balding now when nobody else in my family did not. I am starting to thin in the vertex a little bit. I am interested in starting Propecia. Am I a good canidate for starting Propecia.Do you think I should consult another doctor about my hair loss.

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Genetic balding can come from either side of the family. It could be that you are following someone else in your family line, as not all of the genes are expressed in your father’s or mother’s evident ancestors. You need a diagnosis and your scalp mapped out for miniaturization to find out if what you are seeing is actual balding. If you have genetic hair loss, then Propecia will address the cause and will be far more effective and appropriate than Rogaine, which is a hit or miss product that works better in women and it may work in men who are past the point where Propecia may help. I would not use Rogaine first and I strongly disagree with your doctor.

Propecia and Body Hair (with Photos of Hair Transplant) – Hair Loss Information by Dr. William Rassman

This patient had a very nice result from one hair transplant procedure. An interesting item to me was that he reported that when he started to take Propecia, the hair from his chest and back (which was very heavy) returned to his barely hairy 18 year old body’s hairless appearance. In addition, he also reported a reduction of nose and ear hair. So this patient shows not only the benefits of a good hair transplant, but also a rare but good side effect of Propecia (I have rarely seen been made aware of this loss of body hair). I only have photos of his head, as I didn’t think people needed to see photos of the inside of his nose or ears (and so I didn’t take any).

The first set shows his before photos. Click the images to enlarge.

And this set shows his results after one hair transplant procedure of 2,073 grafts.

Hair Loss InformationNext Line of Cures for Balding – Hair Loss Information – Balding Blog

What can we expect in the next line of cures for balding if cloning, as you suggest, is not going to appear in the next couple of years?

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There are many new approaches for the treatment of male genetic balding that fall below the radar. I tell my patients that there are a few hundred steps to growing and cycling hair in the human body. What we know appears to be very little with regard to the identification of each of these steps and in understanding how each step may or may not be dependent upon each other. There are drugs coming out that will address the hair loss problem, possibly better than Propecia, but it will take time to determine how these drugs work, as many of them were/are discovered by accident rather than by taking a model of the drug that fits into the defective pathway for balding. Once the drug is screened for toxicity in desktop or animal model, the predictability of these drugs in addressing the hair loss problem needs to be identified. Safety and effectiveness (a term I throw around a great deal when I am asked about potions and lotions offered to cure balding) must meet a stringent FDA standard, just to protect the public. I tried to research the drug pipeline to give my readers something to ‘cut their teeth on’, that might give them hope. I have outlined a couple of important articles that will shed light on either the potential of a new drug just recently hitting a press release, or an insight into the risk factors for dealing with new drugs to give the readership of this blog some insights into the scope of the problems and opportunities before us.

Safety determination is no simple job. Even with the most stringent testing for the toxic effects of a new drug cleared from animal testing, the risks take years to define. Unfortunately, the following linked article showed the risks all too soon for the 6 young people who became victims of the drug testing process. The point I want to make here is that you do not want this type of outcome from taking a drug, potion or lotion on any product that is not well tested and through thorough human trials run to strict standards. See: Parexel in hot water over drug trial scare

5% Minoxidil for Women? – Balding Blog

Hello,
I am a 26 year old female and have been using 2% female minoxidil for a little over 6 months. I wanted to ask if it was safe for a woman to use the Men’s Strength 5%. Please advice.

You should use products as directed on the FDA approved label. 5% minoxidil is not available for women, but they are formulated for men. The women’s formulations are mostly water/alcohol based which makes it easier to style your hair. Most men’s preparations are oil based. You can use the woman’s alcohol base in the morning and the men’s 5% oil base at night. Some drug stores will make up the 5% alcohol base on prescription. Ask your pharmacist. Also, please see this article on HairLossTalk.com.




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So Many Products, So Little Results – Hair Loss Information by Dr. William Rassman

Hello. I’ve been experiencing hair loss since the age of 17, I am 20 now. Being in the National Guard and full-time in college, it’s a given I’m under alot of stress. I first noticed my hair started receding at the temples. I began using Rogaine 5% with some success as well as Procerin tablets. Some of the hair began to grow back. I stopped using both products in September of 2005 until December 2005. In December, my hair started to fall out in mass amounts in the shower. I began to use a solution called “Nutrifolica” and Procerin again. Since then, the temples have recovered, but I now have a very distinct patch of scalp showing almost dead center down the the top of my head. It starts from my part in the back, straight forward. It’s weird because the “crown” isn’t really receding (yet, I guess). But it’s fading all the while I’m applying Nutrifolica and taking Procerin twice a day, and using Rogaine after the shower. Oh, and I also tried the Nisim system to no avail. It seems there’s something new on the TV every week on infomercials but it costs $90 for a month supply. That adds up quick.

What are my options? (if any). I’m just completing my freshman year of college and have multiple to go, I’d like to keep my self-esteem in tact, I’m very conscious about my hair.

VacuumYou sound like a bright young man, so I must ask why you are not being smart when it comes to your hair problem? You are selling yourself ‘things’ that you see on TV which are promoted to cure problems with hair loss where the promoters are all profiting from the ‘buy’. Ask a fertilizer salesman what will make your flowers grow, and he will show you his fertilizer products. Ask a vacuum salesmen why you have allergies, and he will tell you that dust in your house is causing it, because the vacuum cleaner you are using is missing the allergens. But what you need to know in the second case is: Are your really allergic to dust? If not, then the $500 vacuum cleaner that this fellow is selling will only serve to make your $500 more foolish and reinforce the idea that maybe you were taken to the cleaners.

I always tell my patients on this blog to first find out if your are losing your hair to genetic balding by seeing an expert who can make a firm diagnosis by mapping out your scalp for miniaturization to determine what is happening to your scalp and hair. If you do have genetic balding, there is a wonderful treatment that really works in young men called Propecia. You could approach this scientifically and know what is happening or you can call that fertilizer salesman for some potion or lotion that will meet his needs and take some of your hard-earned cash.

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Propecia Questions, Part 2 – Hair Loss Information by Dr. William Rassman

Note: This is continued from part 1 that was posted yesterday …

6. I often hear you and others say that stopping Propecia will bring the user to his baseline ‘hair level’ had Propecia never been taken in the first place. This to me seems reasonable, and reassuring. However, I remain a bit skeptical because there is no conceivable way to test that claim. What if hair follicles lose some of their resistance to DHT, simply because they no longer have to deal with it? Is it possible that stopping the drug will make things worse than they would have been? The old “Use it or lose it” saying applies. And this concern carries over to using Minox as well. In case I’m not explaining myself properly, here’s a scenario to illustrate:
Step 1: DHT reaches hair ‘A’.
Step 2: Hair ‘A’ is not adversely affected by DHT.
Step 3: Start using Propecia (presumably to help hairs OTHER than ‘A’).
Step 4: Hair ‘A’ no longer has to ‘fight’ DHT.
Step 5: Stop using Propecia and DHT comes back.
Step 6: Hair ‘A’ is not “prepared” for the DHT onslaught (use it or lose it).
Step 7: Hair ‘A’ is destroyed. Hair ‘A’ would have been fine if Propecia was never used.

How could you say Hair ‘A’ was fine to begin with? The answer is not as simple as A+B=C There are many documented cases where people who gained hair from using Propecia, lost the gained hair when they stopped using Propecia.

7. Propecia has only been around since 1998, Proscar since 1992. So nobody has been on Propecia for more than 8 years. I’m wondering how many people will actually be able to maintain lifetime use of this drug. Unforeseen developments happen in people’s lives all the time, and this should be a pivotal consideration in deciding to go on the drug. Will some situation arise in life that will prevent me from continuing to use Propecia? It’s entirely possible. In your experience, are people able to maintain their use of Propecia, or do you find that people go off the drug at some point?

First, I agree being compliant with any drug therapy for life may be hard. It is definitely something you should consider before starting any elective drug therapy. Likewise, male pattern baldness is also for life. Furthermore, hair transplant is also for life. As you may be aware, these are non frivolous considerations. It is something you and your hair transplant doctor need to consider in making a “Master Plan” for your hair loss.

Second, Proscar is actually protective for prostate cancer.

8. I’ve read your comments in other threads that if a person does not trust the company or the FDA then he should not use their product. This sentiment is all fine and dandy, but things are ne’er so black & white. For instance, recent developments involving Merck & its drug Vioxx cast doubt on the trustworthiness of Merck. And yet that doesn’t mean that Propecia doesn’t work or that its true side-effects have been concealed. Basically I don’t see your point about trustworthiness. Companies have a mandate to increase profits. Sometimes that may lead them to be unscrupulous. Other times they may not need to resort to that. All we can do is ask people in the field, people like yourself, to give us first-hand accounts that will inform our own decisions.

I recommend Propecia to most of my patients with male pattern baldness because I have seen its results first hand. I also recommend Advil for most of my patients with simple arthritis pain.

9. Now, with regards to Minoxidil. I think the general consensus is that Minoxidil plays second fiddle to Propecia when it comes to effectivness. My question is, do you think that Minoxidil is good purely for maintenance, i.e. to prevent further hair loss? Or does the 3-15% statistic that you’ve quoted before apply again? My feeling is that if I go on Minoxidil, eventually I’ll move on to Propecia, so why even bother with Minox in the first place? And there’s something disconcerting about the scientific community not knowing how Minox really works.

You seem to know the answer to this question already!

10. Are Minox & Propecia useful for people who experience what I would call ‘age balding’? That is, people who simply lose a little bit of hair every year throughout their life as part of the regular aging process. Skin doesn’t stay pristine, bones & ligaments don’t either, so should people who don’t experience classic MPB go on these drugs simply to have a fuller head of hair with time? I’ve seen pictures of you (a very handsome man I might add, hehe), and while you’re not bald, I’m sure your hair count is not what it was at 16. Nor do you seem to be suffering from classic MPB. Would you have gone on Propecia or Minox back then to stay looking younger longer?

I am on Propecia now and have been for many years. With regard to your fountain of youth, sorry but there is no such fountain available yet.

11. Personally, I’ve had good hair all my life. Recently, my hairline has matured, and is beginning to look much like my older brother’s. He’s 38, and has a full head of hair, with a widow’s peak (I have one too) and with a slight dracula syndrome (dracula hair with the triangle pattern) whereby there is some degree of temporal hair loss, what is normally termed devil’s horns. When my brother was younger, his hairline was much like mine (although apart from hair, our faces look quite different so I don’t know about relying on my brother’s genetics). He had a widow’s peak with no devil’s horns. I now have progressed to the stage of a low frontal hairline with devil’s horns on the sides just like my brother, maybe a little worse. I can also see the miniaturized hair on the skin where the horns are. If my hair were to stabilize here and progress the way my brother’s hair has, I’d be satisfied. But I don’t want to take chances. Am I wise to embark on this lifelong journey of drugs to prevent the possibility of further loss? I am now at a point where I feel that taking the drugs might restore some of the miniaturized hair, bringing me closer to my freakishly low teenage hairline. But am I being greedy here? These are questions I need to ask of myself, but it’s always good to benefit from the wisdom of others. I’m 23 years old. I do shed quite a bit, and I always have. But I’ve always seen that as a consequence of having a large hair count to begin with. Still, vain as it may be (and I wish I could get past the vanity), I want my hair looking good for as long as possible. But if my hair is not destined to get worse than it presently is, going on drugs would be a waste of money and time. Also, my hair itches often at the sites of hair loss. Moreover I don’t like washing my hair a lot, and I worry that Minox won’t be effective on an oily scalp. I like my scalp to be a little oily for styling purposes so I’ll shower every other day, or every other 2 days (I wash my body daily however). I’m looking for your advice, what you would do if you were in my shoes.

At 23 years old, you may be at the beginning stage of losing your hair. You need a good hair transplant doctor to evaluate the miniaturization process and map your hair loss. If your doctor recommends it, you should then be using any possible Propecia treatment. But with respect to your teenage hairline, I doubt Propecia can restore that.

12. What is the significance of shedding hair with the white bulb at the base, versus shedding hair without the white bulb? Just a general hair question.

The presence of a ‘white’ bulb at the end shows some mucus associated with the hair that you are looking at. Generally the presence of a complete hair follicle with or without a white mucus bulb is of little significance, provided that there are few. There is a specific test that determines to which degree hairs will come out when pulled upon. Normally, only a few hairs will come out of a group of hairs that are pulled upon. What a pull test will show is that if a large percentage of hairs that are pulled upon come out, then some disease process may be going on.

I hope that everything was answered to your satisfaction. If you have more questions, please feel free to comment or contact me.