Why Doesn’t Propecia Work For Dupa or Female Pattern Balding?

In a previous question you said propecia doesn’t work for DUPA. Isn’t DUPA miniaturization of the follicle we see in Aga and FPB. I have seen that most cases of FPB also has some degree of thinning on the whole head, back and sides. I thought it had already been proven that dht caused miniaturization of the follicle. If not DHT then what are the other causes of hair miniaturizing? Actual miniaturization and not just hair falling out like TE or AA. Miniturization of anykind has been said to be the hallmark on diagnosing all AGA. Could it be that it does work at the same percentage as it does in mpb but because we see so much less cases of DUPA and by the time it shows you need to be at the point of 40-50% loss. Is it more a game of not being able to catch up after such loss.

I believe there are some misconceptions here I would like to clear up.

Male Pattern Balding is a genetic condition in men. In other words if a man was born with the gene(s) for MPB, he will have a hair loss in a certain predictable “pattern” (thus the term Male Pattern Balding). Scientist have found if a man has the gene for MPB, a hormone called dihydrotestosterone (DHT) is partially responsible for his hair loss. If a man does not have the MPB gene, DHT will not cause hair loss. Propecia is a drug that block the DHT action and it works in men who have the genes for MPB.

Propecia will not work for DUPA or Female Pattern Balding because hair loss is not a related to DHT and it is not related to the gene for male pattern balding. DUPA (Diffuse Un-Patterned Alopecia) is similar to generalized hair loss in women and as such is not impacted by the drug Propecia (finasteride).

Miniaturization is just a phenomenon seen in the hair loss process. You will see miniaturization in naturally shedding of hair in a non balding person in some of the hairs at the end of their normal cycle. A non balding person will have up to 20% of miniaturized hair (many of them actually vellus hairs that are small, very short hairs found in each follicular unit in all people). Hairs go through natural cyclex of growth and shedding (anagen, catagen, telogen). A person with MPB will likely have more than 20% of miniaturization in a specific pattern around his scalp. A person with DUPA will likely have much more than 20% of miniaturization all over the scalp in a non specific pattern (thus the term Diffuse Un-Patterned Alopecia).

Rogaine Foam Response Time?

Dr. Rassman,
I am confused as to why you said it would take 1-2 years to see results with Rogaine 5% Foam versus the 3 to 4 months that is usually mentioned for any results. I thought the cycle of hair growth is generally a four month turnover process and am wondering why you said I would need to wait 1-2 years. Again, I am a 48 year old female with androgenetic alopecia. Thank you.

It takes time for the hair to grow out, so any benefit of minoxidil that is obtained in the 4-6 month hair cycle, needs to grow to styling length to see value. Sure, you might see tiny baby hairs sprouting up, but those aren’t at a length that is manageable. Hair grows at the rate of 1/2 inch a month, so by adding the numbers together, we get to the estimates I gave before —

+ 4 months (growth cycle)
6 months (to grow a three-inch hair length)
= 10 months

Then add to this the reality that it may take up to a year for the full benefit of the minoxidil to be realized.


2008-03-12 15:22:03Rogaine Foam Response Time?

My Donor Area Is Very, Very Thin After My 4000 FUE Surgery, Why Is That? (Photo)

4,500 FUE grafts is a high number of FUE grafts for anyone with a lower than average donor density.

If you are from India or South Asia, your donor density will not support that number of grafts and thus you have a depleted donor area.

Scalp Micropigmentation is the only solution to this problem (see: https://scalpmicropigmentation.com/scar-covering/).

Screen Shot 2018-08-22 at 7.47.15 AM

 


2018-12-01 08:09:56My Donor Area Is Very, Very Thin After My 4000 FUE Surgery, Why Is That? (Photo)

Rubbing Areas of My Head Caused Thinning

hey dr
this is gonna sound weird but i used to work in a job that involved lifting boxes all day. i lift them on my right shoulder and the boxes would always rub the side of my head and right
eyebrow but i noticed the hair on the right side thinning and also the eyebrow on the right side missing hair and i figured out that all the constant rubbing over the years had caused it. i
have a full head of hair all over except these affected areas. ive made sure over the last year not to touch my head with the boxes but ive noticed no regrowth. i was just wondering if you could suggest anything to use on my the affected areas to promote new hair growth that wont maybe lead to further hairloss as ive heard a lot treatments like rogaine once stopped can cause further hairloss. thanks

What you are describing seems to be a form of traction alopecia, where repeated tension on the scalp and hair causes hair loss. Rubbing hair also puts a pull on hair that is near the end of its cycle. If you have constant traction, this type of hair loss can be permanent. You can try Rogaine in those areas to see if some hair will grow back.


2007-07-17 10:32:11Rubbing Areas of My Head Caused Thinning

Dostinex (Cabergoline) and Propecia

Dear Dr. Rassman,

I’m a 28 year old male. About 6 months ago I was diagnosed with a rare pituitary condition called hyperprolactinemia. This disorder is genetic in my family, and mine is a very mild case. The treatment is a single half-dose of cabergoline (marketing name Dostinex) taken once a week.

Male pattern baldness also runs in my family and I’m starting to show thinning on the crown of my head. My dermatologist suggested I try the propecia/rogaine route. Since propecia affects the endocrine system I am a bit reluctant to take it without knowing more about possible side effects or interaction with the cabergoline. I don’t think it should and my dermatologist said she wasn’t aware of anything and I haven’t found anything about it on the web, but I wanted to get another opinion before I started propecia. I also read online that minoxidil from rogaine may have a side effect of increasing prolactin – the condition I have too much of. Do you know of any cases like this? If so, should I reconsider starting propecia, rogaine, or both?

Thanks!

At this point, it is very difficult to accurately assess the cause of your thinning hair. As far as I know, cabergoline does not have hair loss listed as a potential side effect, however, this does not mean that this drug can not cause this in you. Also, certain diseases / stresses to the body have also been known to cause hair loss. Lastly, as you have mentioned, male pattern baldness could be the cause of your thinning hair. You definitely need a miniaturization study to determine the extent and locations of most of your hair loss (i.e. does it correspond to MPB?).

There have been reports that minoxidil may be related to the development of hyperprolactinemia, definitely something you don’t need more of (see Drugs.com – Interactions between cabergoline and Minoxidil). The main point here should be that before you start any medication, whether it be Propecia or Rogaine, you should have a coordinated discussion between your physician that is treating you for the hyperprolactinemia and your dermatologist. To answer your question though, I haven’t read about Propecia (finasteride) and cabergoline interactions, but again, please discuss this with your prescribing physician.


2008-01-15 13:12:15Dostinex (Cabergoline) and Propecia

Dr. Rassman Speaks About The Tedium Of Doing FUE Manually At The Artas User Conference

There is little doubt that the ARTAS robotic System is less stressful for the surgeon than than the manual Folliclar Unit Extraction (FUE). Some of our patients are driven by the technology as we have seen some of them ask for the ARTAS robotic system. We offer both the manual and the ARTAS FUE for our patients at the exact same price of $8/graft at this time. From a quality perspective, both techniques are identical. We have been doing FUE since the mid-1990s, so we are pretty good at it. The manual FUE in Dr. Pak’s hands is a faster procedure when compared to the ARTAS system making for a shorter surgery.

Please comment in our comment section and ask more questions about these two FUE procedures. If we are doing an ARTAS FUE on the day you visit us, ask if you can see it in action and if the patient agrees to allow visitors, we will let you observe the ARTAS in action. For more about the ARTAS robotic system go here: https://newhair.com/procedures/fue/fue-artas-robot-robotic-fue-surgery/

Scalp Burn Treated with Balloon Expander, How is it Done?

let’s assume that the burn is in the front and top of the head. A balloon is then placed in the crown to expanded in the scalp over a couple of months. Each week, about two times, fluid is injected into a ‘port’ on the balloon. With each injection, the balloon expands until it is stretched enough with enough redundancy to cover the burned areas. Then the burned scar is removed and the new scalp is advanced forward. I have been involved in a number of these challenging cases and the results are very rewarding. I have seen fully half of the scalp burned and treated successfully this way, sometimes with added hair transplants for fine tuning the process.


2020-03-05 15:03:59Scalp Burn Treated with Balloon Expander, How is it Done?

Dreadlocks cause balding (photo)

This is an example of a man who is balding and is making it worse by wearing a dreadlocks hairstyle. He would be better off shaving his head to preserve his hair than by pulling it out and getting traction alopecia from this hairstyle.


2020-09-01 09:48:52Dreadlocks cause balding (photo)

Scalp MicroPigmentation of FUE Combo Review for Norwood 5 Patient

This is a review of what is possible when you combine Scalp MicroPigmenation (SMP) with a hair transplant surgery using the Follicular Unit Extraction (FUE) technique performed at New Hair Institute by Dr. Jae Pak.

The following patient is in his 30’s and always wore hats. Even in the house with the family or with friends he wore hats because he was not happy with his balding pattern. He eventually decided on a FUE procedure because he didn’t want the linear scar on the back of his head in case he wanted to shave his head in the future. If all else fails, he thought at least he can shave his head without any worries about scars. He eventually went on to have 3 FUE surgeries over the years as his hair loss progressed and received about 5000 grafts. Despite the new look and the permanent transplanted hair, he wanted fullness and even wanted to shave his head for a buzz cut look.

Eventually, he had the Scalp MicroPigmentation procedure and he had the best of all scenarios: He can cut his hair long or short and he will always have the look of fullness.

Note that hair transplant procedure is a great option for those who are balding. But you will never get full thick hair since the basic concept of a hair transplant surgery is just relocating hair from one location (back of head) to another location (front and top of head). There is nothing new being added. Hair transplant is basically artistically rearranging the hairs around. Scalp MicroPigmentaion is used to augment the limitation of a hair transplant to provide the look of fullness by minimizing the contrast between hair and scalp.

This patient finally threw away the hat he wore for so many years.

FUE immediate after/  FUE scars hidden by SMP

FUE immediate after/ FUE scars hidden by SMP

Before and After FUE Hair Transplant (NO  SMP)

Before and After FUE Hair Transplant (NO SMP)

Before and After FUE Hair Transplant (NO  SMP)

Before and After FUE Hair Transplant (NO SMP)

Before and After FUE Hair Transplant (NO  SMP)

Before and After FUE Hair Transplant (NO SMP)

Before and After FUE Hair Transplant  AND Scalp MicroPigmentation (SMP)

Before and After FUE Hair Transplant AND Scalp MicroPigmentation (SMP)

Before and After SMP - BOTH photos are after hair transplant surgery (NOTE: shaving does not make hair transplant look as full)

Before and After SMP – BOTH photos are after hair transplant surgery (NOTE: shaving does not make hair transplant look as full)

Before and After FUE Hair Transplant  AND Scalp MicroPigmentation (SMP)

Before and After FUE Hair Transplant AND Scalp MicroPigmentation (SMP)

Before and After FUE Hair Transplant (NO  SMP)

Before and After FUE Hair Transplant (NO SMP)

Before and After SMP - BOTH photos are after hair transplant surgery (NOTE: shaving does not make hair transplant look as full)

Before and After SMP – BOTH photos are after hair transplant surgery (NOTE: shaving does not make hair transplant look as full)

Before and After SMP - BOTH photos are after hair transplant surgery (NOTE: shaving does not make hair transplant look as full)

Before and After SMP – BOTH photos are after hair transplant surgery (NOTE: shaving does not make hair transplant look as full)

Before and After FUE Hair Transplant (WITH  SMP)

Before and After FUE Hair Transplant (WITH SMP)

Before and After FUE Hair Transplant (NO  SMP)

Before and After FUE Hair Transplant (NO SMP)