Free Testosterone Declines with Propecia Use?

Dear Dr. Rassman,

I am a 31 year old male who has been on Propecia for 5 years. After getting bloodwork done, it was discovered that while my Total Testosterone was high, the percentage of Free Testosterone was proportionately low.

Then, I discovered an article from an Egyptian medical journal entitled “Effect of Oral Finasteride on Serum Androgen Levels and Androgenic Alopecia in Adult men”, which found that all men in the experimental group experienced a decline in free testosterone after taking Propecia relative to no change for those taking a placebo. Were you aware of this? Does this not add to the growing body of literature showing how dangerous Propecia really is?

The main point of why Propecia (finasteride 1mg) works is because it changes DHT hormone levels. DHT is the result of testosterone catabolism (it is a byproduct of testosterone metabolism). So to say Propecia affects testosterone in some way is valid, but I cannot say what this really means. The study you refer to included only 30 men and it does not go on to state what the implication is or what the significance is of the findings.

For those interested, the study can be found here (PDF file).

These are the type of articles that can cause confusion and add fuel to the never-ending debate on Propecia depending on how you parse the information presented. Anyone can quote articles and infer what they want, but the real meaning or significance is unclear. At least this is interesting reading. Let the debates begin… or rather, continue!

Switching from Cut Proscar to Propecia

Hi,

I’ve been going for hair transplant surgery last 2 months and after the surgery the doctor recommend me to take propecia to maintain my existing hair as i was indicated of suffering from Male pattern hairloss. Just 3 days ago i start to apply Proscar and split it into quarter 1.25 mg as financial problem and use it daily without side effect so far. Surprisingly my hair stop to fall off immediately as only used for 3 days..

My question is now i am taking 1.25 mg of proscar daily, and i plan to switch to Propecia 1 mg after 2 years from now on. Is there any case of intensive shedding happened if switching from Proscar 1.25 mg to Propecia 1 mg? As most of the cases is only mentioned switching from Propecia to Proscar for cost saving.

Thanks for your sincere advice.

Cheers.

Proscar and Propecia are both the drug finasteride just at different doses. Switching between them is no problem at all. The difference in the 1.25mg dose and the 1mg dose is relatively insignificant.


2009-07-01 15:27:15Switching from Cut Proscar to Propecia

FUE Doctor Recommendation

I started my research on the fue procedure about six months ago and have come accross an organization known as DHI. My cousin had an fue transplant from them last year and recommended their work, their website is full of info and they have numerous locations. BUT, until I stumbled upon your website, I didnt know half the things I know now, for example the fact that a Doctor is best trained to perform such procedures and that one should look for endorcements from pioneers in the field. While browsing their section on what doctors say about their procedures, I found that your name was listed. PLEASE could you tell me if DHI is a good choice for my procedure, as after studying your credentials I graetly value your opinion. If I dont go with DHI, your organization will be next on my list. I thank you for your time in advance and will greatly appreciate your proffessional advice.
Thank you.

With regard to FUE, the field is still new and most of what I read/hear is through the advertising of particular doctors who promote FUE. From an insider point of view, I suspect some doctors who promote their skills in this area are not able to do a competent job at FUE, but I am not willing to name them because of possible slander issues and my lack of good solid information. This site is not put together to police the profession, but to give good advice to people like you on questions covering the entire range of subjects with regard to hair care. In searching out a doctor, you should always meet patients that they have done to be assured of the skills of that doctor. You would want to get good vibes on that doctor.

A while ago, I got a list of 500 patient references (source was a doctor who I knew was terrible and unethical). I picked up the phone and called the first 20 references that the doctor listed. Every one of the references (all had surgery with that medical group) told me horror story after horror story. I then realized that by publishing such a list, that particular doctor knew that few patients would make the effort to actually call these people and that the list of 500 references was enough to produce the credentials he wanted. This shows that when you do your research, you MUST follow the threads until you have clarity on the inquisition. This is a buyer’s market and as a buyer, please beware.

For information on FUE, please see:

Take Propecia With or Without Food?

Is it possible and/or safe to use propecia and minoxdil at the same time or is it not recommended to take these together. Additionally, if I take propecia, is there a recommended method of taking it – ie with/without food, empty stomach, without other medicines or vitamins.

Thanks.

You can use Propecia (finasteride) and Rogaine (minoxidil) together. It doesn’t matter if you take it with or without food.

FUE / FIT — Minimally Invasive Hair Transplants

Hello Dr Rassman,
Firstly I would like to congratulate you on this website. Its very helpful. I am due to have a FUE transplant (1000 follicles) next month at DHI in Athens. I have read your comments relating to DHI and the importance of a good surgeon.

I know that you normally refrain from doing this but I would really appreciate it if you could please recommend a paticular doctor (whose work you know of) at DHI. I am really freaking out now about getting an incompetent surgeon working on me. I realy dont want to make a wrong decision. I will not dislose your recommendation in any way at all to anybody. Thank you.

I do not know any of the doctors at DHI, so unfortunately I can not help you with that. I am told that they have switched completely to FUE and away from strip harvesting. Frankly, that makes me nervous, because of the complete absence of biopsies to qualify patients. DHI was taught by Dr. Cole, who calls his procedure Follicular Isolation Technique (FIT), which is a sub-set of what I call FUE. Dr. Cole, along with DHI, tell me that 100% of patients qualify. The FUE techniques are a series of processes that are fine tuned in each patient, as each process works uniquely in different patients. Dr. Robert Bernstein and I just wrote a chapter in a new text book on this very subject (due to be published shortly). FUE is an intricate process that requires a series of approaches, each matched to the patient’s tissue characteristics. Last week, for example, I performed an FUE procedure and prior to that procedure on an earlier visit, I used four different methods to optimize the process. One tool worked consistently at 100%, while others methods had failure rates in the same patient ranging from 90-20%. At the time of the surgery, the actual success rate was 88% based upon hair counts. For this very reason, I am absolutely convinced that biopsies are needed to qualify patients and match the techniques that work on that patient prior to the actual FUE surgery. On a few patients, FUE surgery is either not possible or so inefficient (taking a few hours per hundred grafts harvested) to make the process not a reasonable alternative to strip harvesting. Depending upon the technique used, patient eligibility ranges from as high as 95% of all patients in some doctor’s hands (very few doctors fit into this category and this group includes those patients who may not be efficiently harvested) to less than 30% in others.

What bothers me is that some doctors have a loose definition of FUE success. Some doctors may classify 100% success as his/her ability to extract at least one hair in an FUE graft. That does not cut it for me, because I classify success by hair count. That means that if a 3 hair graft was excised with FUE, some doctors would call a single hair extracted and two hairs killed off as 100% success while I would call it 33% success (actually this does not quantify the loss of hair, the negative value of hair that is lost forever). Probe the doctor’s definitions here and get an accurate count of what he did when he does the procedure, as you are entitled to that as part of your medical record. If the doctor does not give it to you or tells you that it does not matter, run for the hills. It may sound like technical talk, but the realities of what you get and what you pay for and what is destroyed by the process all come into the value equation. Again, as I always say, let the buyer beware!

Taking drugs with hair transplant

Doctor, if you get a hair transplant, do you have to take fin and minox? Or are you solid to discontinue?

That depends upon how much miniaturized hairs are at risk of shock loss. Finasteride prevent shock loss. Generally, the older you are, the less the risk of shock loss. Some people don’t want to take drugs so that elect to have a hair transplant which doesn’t require drugs of any type but there can be a loss of miniaturized hairs without finasteride which may reduce the value of the hair transplant for some patients.

I had FUE 1 month ago and now have a tender hairline

What you have appears to be an infected hair follicle cyst which we often call a boil. You should see your doctor and he most likely will drain it and relieve your pain.

boil


2017-09-15 13:46:33I had FUE 1 month ago and now have a tender hairline

Taking Propecia Before the Sun Rises

Hey doc, I need this question answered ASAP, if you wouldn’t mind. As you may know, Ramadan has begun and many Muslims will be getting up in the middle of the night to eat and drink, for eating and drinking aren’t permitted until the sun sets.

So if I take Propecia before the sun rises, like around 4 AM or so, would it have the same effect as taking it later on in the day? Thanks

You can take Propecia (finasteride) at any time. Just take it about once every 24 hours (day). I generally recommend taking it when you wake up in the morning, when your testosterone is highest and if that is 4am, it will work as well at that time.

Fungus on Scalp

i had to move out of my home due to fungi spores outside home was over 5000 and was consuming the inside of new home also. i am very allergic and had to be put in hospital, i have been on flagyl for 3 wks now and i still have bacteria,and fungi internally and on scalp. is it normal to constantly pass black and red dots from scalp and is this scalp fungus? going bald,and intense itching for 6 months now. please give any suggestion. thank you so much

It sounds like you have some serious issues. I would follow the recommendations from the doctor who is treating you. It is impossible for me to give you any medical advice over the Internet, as I am not your doctor. I can only give general opinions as a doctor. I do not know what “black and red dots” you are passing on your scalp, and I would have to see them to get an idea of what you’re talking about. It certainly does not sound normal.

Again, you need to ask these questions to your doctor who can actually examine and see what those “black and red” dots are. Sorry.

Tapering Finasteride

I have a question about Finasteride tapering (I seem to remember something about this on your website, but can’t access the link now). Basically, is there any recommended dosage regime to slowly taper yourself onto the usual 1mg/day dose? i.e. working your way up from 0.5mg once a week, then up to 0.5mg EOD, then 1mg EOD, then 1mg daily, over a period of a couple of months? Or could this kind of slow tapering actually be harmful?
If you are having side effects from this drug, you can just stop it. Tapering it will not alter the “catch-up” hair loss that many people who stop the drug experience. Catch-up hair loss reflects a loss of all of the hair that did not fall out or was gained from the drug, and the person who stops the Finasteride will see this effect within 3 months.


2018-05-18 08:32:28Tapering Finasteride