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Study on topical finasteride with minimal sexual side effects reported

https://www.ncbi.nlm.nih.gov/pubmed/26636418

2016 Jan;54(1):19-27. doi: 10.5414/CP202467.

Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia.

Caserini M, Radicioni M, Leuratti C, Terragni E, Iorizzo M, Palmieri R.

Abstract

OBJECTIVE:

The effects on scalp and serum dihydrotestosterone (DHT) of different doses of a novel topical solution of 0.25% finasteride (P-3074), a type 2 5?-reductase, were investigated in men with androgenetic alopecia.

METHODS:

Two randomized, parallel-group studies were conducted. Study I: 18 men received 1 mL (2.275 mg) P-3074, applied to the scalp once a day (o.d.) or twice a day (b.i.d), or 1 mg oral tablet o.d. for 1 week. Study II: 32 men received P-3074 at the dose of 100 (0.2275 mg), 200 (0.455 mg), 300 (0.6285 mg), or 400 (0.91 mg) ?L or the vehicle o.d. for 1 week. Scalp and serum DHT and serum testosterone were evaluated at baseline and treatment end.

RESULTS:

Change from baseline in scalp DHT was -70% for P-3074 o.d. and approx. -50% for P-3074 b.i.d. and the tablet. Serum DHT decreased by 60 – 70%. The doses of 100 and 200 ?L P-3074 resulted in a -47/-52% scalp DHT reduction, similar to the 300 and 400 ?L doses (i.e., -37/-54%). A -5.6% inhibition was observed for the vehicle. Serum DHT was reduced by only -24/-26% with 100 and 200 ?L P-3074 and by -44/-48% with 300 and 400 ?L P-3074. No relevant changes occurred for serum testosterone.

CONCLUSIONS:

The novel finasteride 0.25% solution applied o.d. at the doses of 100 and 200 ?L results in an appropriate inhibition of scalp DHT potentially minimizing the untoward sexual side-effects linked to a systemic DHT reduction.


2019-10-01 10:13:12Study on topical finasteride with minimal sexual side effects reported

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FlutaGel

What can you tell us about FlutaGel?

Flutagel is a gel that contains 1% flutamide as the active ingredient, a drug that is used to treat prostate cancer. It acts by inhibiting the uptake and/or binding of dihydrotestosterone (DHT) to the target cell receptor. To date, no clinical studies have been done to prove its efficacy in MPB. In theory it sounds great, but this does not always translate into the clinical arena. It needs to be studied further to evaluate its safety and effectiveness.

The website for this is at Sinere.com if you want to try to find more info.


2008-02-13 11:10:38FlutaGel

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Suddenly Thinning Hair in Mid-30s

Two years ago I was getting my hair thinned out by my stylist because it was to thick. Two years later at age 37 my hair is considerably thinner. The thinning is more prevalent on the left top side of my head. The initial thinning was drastic and took place within a couple of months. Should I expect for this to continue at such a fast pace or will it slow down. My mother’s side of the family has little issues with hair loss while my father’s side does. Beside genetics what possible causes would be responsible for this to happen in the timeline it has?

First, I would want to map out your hair to see if this is symmetrical balding. At times, genetic hair loss is asymmetrical and will show miniaturization in the areas most impacted. Get to see a good doctor for an assessment. I can not help you over the Internet and would need to see you myself.


2008-12-23 13:51:15Suddenly Thinning Hair in Mid-30s

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Foltene Study from 1987

What do you think of this published clinical study? Foltene study

They concluded that Foltene is an effective and agent for male pattern baldness, alopecia areata and seborrheic alopecia with pretty good results.

The study you referenced was published almost 25 years ago in the Journal of Korean Medical Science and included only 30 men, ten of which had male pattern baldness. That study is simply too small for me to seriously consider that the results show an effective treatment. Besides, if there was really something to this I would expect in the decades since it was published there would be more information and larger studies available. If they exist, I can’t find them. In particular, the study claims regrowth for patients with alopecia areata, and I know the alopecia areata community would’ve been all over this had it been real.

There’s a product sold in Europe by that name, but I’m not sure it has the same ingredients that the study mentioned. We’ve written about that Foltene before here.

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Surgical Camouflage of Pluggy Hair Transplants (with Photos)

This patient had 1414 grafts almost 12 years ago to camouflage the obvious grafts in his frontal hairline and in the process, bring down his hairline into its normal position. His old transplants were placed too high and looked too pluggy. This is a nice result and a good demonstration of the value of camouflage when used properly. The photo on the left is before I performed any transplants on him (note the plugs there on the close-up), and the photo on the right is over a decade later. The key to the camouflage was to create a feathering zone of one hair grafts irregularly placed and spaced apart in front of the plugs, then with two hair grafts placed closer together, the transition to the old plugs was so gentle that the plugs were hidden from view. The patient was thrilled with the results.

When we wrote the original articles on repairs for the medical journals, it was taken from experiences like this man had. Today, we can harvest hair from the big plugs (not shown in these photos) as well as use camouflage as we did here. When this repair was done in 1995, the unfortunate standard of care at the time was still the ‘plugs’ that produced the corn row deformities. Surgeons were trying to repair the rough work by putting even more large grafts in between the larger grafts, which only compounded the problem. Fortunately today, few of these pluggy procedures are done and much of what we published has become today’s standard of care for repairs. To see the original work we did on the subject and the publications, look at: NewHair.com – Repair (search).

Click the photos to enlarge.


2007-03-21 19:14:43Surgical Camouflage of Pluggy Hair Transplants (with Photos)

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Frequent emails from many of the same patients asking me about their surgical problems

I get emails every day from patients who had their surgeries from all over the world and couldn’t get their doctors to return their phone calls. One man today told me that his doctor always returned his phone calls when he had questions BEFORE the surgery, but will not now return his calls. Some doctors think that you, the patient, is here for them to make money from. They sell you their services, treat you well until you go forward with the surgery. Then it is the next patient, not you, then gets their attention. Immoral doctors behave like this!!!!!!!


2019-09-05 08:37:12Frequent emails from many of the same patients asking me about their surgical problems

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Switching from ScalpMed to Generic Minoxidil

I was unable to access your link that campares Rogaine to ScalpMed. The link is broken. Therefore, my question to you is this: Is the only ingredient in Scalp Med, (when mixed with “Vitadel” which is simply minoxidil) that actually effects hair growth Minoxidil? I suspect that all these similar products are merely inactive ad-ons since the only common ingredient ALL the products have is that they must be mixed with minox.

Is that so? In other words, if the product works for me-and it does so remarkably, would I see the same results by simply using the $20 a bottle minox and not spend the extra $100+ on the Scalp Med or Follicare, etc.?

I’d be very grateful if you could clear this up for me as I love the results but simply cannot afford their prices anymore. And stopping using will cause the new hair to fall out. Also, do
you think that a DHT blocker is important and/or effective in combo with minox? I look forward to your kind reply. Thanks much.

ScalpMed, as we stated before, does not have any scientifically proven ingredients besides minoxidil and I do not see any reason why minoxidil should not be as effective, possibly even better.

There has been some research done on topical DHT blockers (mostly by Japanese researchers), which shows effectiveness of these products. I guess I would like to see more research on larger groups of patients before recommending them to my patients on a regular basis.

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FUE Donor Safe Area Not Respected In This Patient (photo)

Your donor area removed is too high on the fringe, and it goes all the way down to the neck area with excision of these hairs as well. This is outside of the safe zone and the areas that doctors believe the hair will last a lifetime. I hope that your doctor discussed this with you because some of this hair may not last a lifetime and some might not even grow.

outside donor area


2018-06-22 13:04:21FUE Donor Safe Area Not Respected In This Patient (photo)

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Taking 1.25 mgs finasteride 3 times a week

Got the 5mg pill of Finastride and am thinking of taking 1.25mg on Monday, Wednesday, and Friday, skipping Saturday and Sunday and restarting the same routine

That is essentially taking 0.54mgs daily. Merck reported that 0.5mgs is 82% as effective as the full 1mg dose, so this plan is a reasonable plan. The benefits are not the blood levels for finasteride but rather the tissue levels which hang around for a few weeks after taking the drug,

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Why Is FUE Not a Popular Surgery? (from Reddit)

As the person who pioneered FUE, it is now the most popular hair transplant done worldwide. The doctors starting doing FUE when I published the first paper on the subject here: https://baldingblog.com/wp-content/uploads/pdf/mp-2002-fue.pdf. The public started to demand it, and within a year, doctors from all over the world were offering it but were doing it very poorly. Then, I licensed the hair transplant robot that we invented in 1998 to hopefully standardize the FUE. Over time, instruments got better and better and so did the doctors. Now, in every country in the world, FUE is a standard procedure for hair transplantation. Be careful as not all doctors perform FUE well.

Why aren’t FUE transplants a bigger deal? from tressless


2018-09-24 06:24:25Why Is FUE Not a Popular Surgery? (from Reddit)