Eucapil – Comments from the Inventors – Hair Loss Information by Dr. William Rassman

I received this comment to my post from last month about Eucapil from M. Sovak, M.D., University of California Medical School –

Response from the inventors of Eucapil:

We understand that a comment by Dr. Rassman was published on the site consecrated to the surgical hair loss restitution. We therefore understand that plastic surgery will remain the priority of its practitioners.

We nevertheless have to correct a number of statements which are erroneous:

1. Eucapil is not a cosmetic available only in “the Czech and Slovak countries”. Eucapil was approved as a cosmetic in the Czech and Slovak Republics and thus under the EU Law of Cosmetics can be made available in all EU countries.

2. The definition of a cosmetic in Europe is not the same as in the US and the producer of Eucapil, Interpharma Praha, is not making any medical claims whatsoever. In the EU, a cosmetic is a product which acts on the skin and its appendages without having any systemic effects.

3. It is not clear what “good things for the appearance of hair” means. To state that there is no suggestion or proof that Eucapil can reverse hair loss is simply untrue. We refer the reviewer to the appropriate scientific presentations and articles in peer-reviewed journals on the website, www.eucapil.com (Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M. 2002. Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience. Dermatol Surg 28:678-685, with an erratum on p.971; Bienova M, Kucerova R, Hajduch M, Fiuraskova M, Sovak M. Efficacy and Safety of Eucapil Gel in hirsutism (Pilot Study). Proceedings of 14th Congress of European Academy of Dermatology and Venereology, London, October 12-16, 2005; Kucerova R, Bienova M, Novotny R, Hajduch M, Fiuraskova M, Seligson AL, Sovak M. Eucapil in Female Androgenetic Alopecia: Efficacy and Safety after 9-month use. Proceedings of 14th Congress of European Academy of Dermatology and Venereology, London, October 12-16, 2005).

4. Everybody in hair dermatology knows that the reversal of hair loss can occur only if the follicles are still viable and this applies to systemic therapy such as one with finasteride (Propecia) or the topical material such as minoxidil (Rogaine). We agree, however, with Dr. Rassman that the ultimate and best way of dealing with hair loss which can no longer be reversed is to use implants and other plastic surgery approach which today has been developed to excellence.

5. Eucapil IND has recently been filed with the US FDA with all relevant preclinical and clinical information. We should perhaps state that the primary endpoint of the studies is arrestation of hair loss of those who suffer from continuous effluvium (hair fall out) and that as a secondary point and based on clinical observation there is a statistically significant increase in the hair diameter which may be responsible for the overall improved appearance of the hair. We wish to be sure that the readers of this response understand that Interpharma is not a “producer of natural supplements” which pushes “claims that may not be valid”. Interpharma works strictly under good manufacturing practices (GMP) and publishes its findings in recognized journals. More information for anyone who would wish to read scientific abstracts is contained at the Eucapil website, www.eucapil.com.

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Does Propecia Work In The Front? – Balding Blog

hello doctor! i have question about propecia. i have a class 2 or 3 hairline but it is thin. i first heard that propecia only works in the back of the head? now i hear it can work where thin hair is growing as well? even in front, so can propecia work in the front as well? thank you

I am sure that Propecia will slow down loss in the front. If you are losing your childhood hairline, this drug may not stop the maturing hair loss evolution. If you are balding in the classic sense, then get your hair mapped out for miniaturization so that you can get a real diagnosis to know where you are going from here. Also, see here for more about mapping.




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Accutane Warning from a Woman Who Took It – Hair Loss Information by Dr. William Rassman

Hi,
I took Accutane 2 times for the past 3.5 years and have lost about 70% of my hair. I has improved a tiny bit, but it’s not the same every since. It is very thin and dry, and UGLY looking. I also developed lots of other problems after this crapy drug: vision problems, dry eyes, dry skin, joint pain, high billirubin and thyroid problems. And it didn’t even cure my acne! My hair stopped falling out about 7-8 months ago, and I still don’t have any regrowth, I have very-very little… There is no family history of hairloss, my 78y.o. grandmother has better hair than I do. Accutane has be taking off of the market, it’s very nasty drug, I wish more people would know about it!

This is one of the worst hair related comments I have received about Accutane. The list of potential side effects is long (see below). The doctors who prescribe it know more about the frequency of such side effects than I do as I only see the worst examples of the hair related problems from it, so I can not advise people who are reading this blog on what to do if they are prescribed Accutane. Speak with your doctor, ask all of the right questions, read the material that comes with the drug and look up more information, starting here:

Hair Loss InformationMiniaturization or Gimmick? – Hair Loss Information – Balding Blog

Dear Dr. Rassman.

I have a 3-in-1 question for you. Thanks for answering my previous question about Propecia. I am trying to cover my loss by all available means (Propecia, supplements, Minox and finally a transplant.)

First, I noticed you talk about getting one’s head mapped for miniaturization. I have spoken to five dermatologists here in Arizona, including two who specialize in hair transplants, and none of them have an idea what “mapping head for miniaturization” is. One of them even went as far as suggesting it was just a gimmick to get people to go on with the surgery. (Which I doubt.) I absolutely need to know to what degree my loss might be, so I can plan for the future, transplant and money-wise. The dermatologist who prescribed Propecia for me only took a 30 second look at my hair and gave me the prescription. I think that was a bit wrong, as it might be something else what’s causing my loss, though there is a history of it in my family. So…

Is there a doctor you can refer me to, who can perform the mapping, here in Az? The doctor who mentioned the “gimmick” said such analysis is pointless, as one miniaturized hair might be non-miniaturized by the next cycle. (I doubt it.)

Second. Another concern is how much it can evolve. I know balding is a progress, but I would like to know if a mapping can ascertain if I’ll be a say, class 4 for the rest of my life as it can be obvious some hairs are not affected by DHT, or if it will only tell me what class I am at a certain point in time, with the potential for more balding.

Third. I am concerned I might not have enough hair to leave me satisfied with my appearance even after a transplant. My main concern is thinning, as the recession is not that noticeable. I am curious to know if you can transplant hair from other parts of the body like chest or belly. I have long enough hair there that looks identical to my head hair, save for not growing longer than 1 or 1 1/2 inches. I wonder if this hair can be successfully transplanted to provide thickness, or work as “guard hairs” for the frontal hairline. I noticed my brother’s frontal hair is just like that. Other doctors in Australia (Who happen to follow your procedures and credit you with the techniques they use) have been successful in patching people up with body hair, with amazing results.

Sorry for the long post, and if some of my questions are not too clear. Keep up the good work, doctor, and hope to be stepping up into one of your offices soon.

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I just answered a similar question a couple of weeks ago, but I’m going to get a little more in depth this time…

The hair transplant medical field is not as standardized as one may think. There is the International Society of Hair Restoration Surgery (ISHRS), but not all hair transplant doctors belong to the society or practice the same way. Some doctors do not use microscopes for dissection. Some doctors do not use hair densitometers to determine miniaturization. Some doctors do not use follicular units. These should be the standard of practice in my opinion, but there is really no way to enforce these practices. Unfortunately, hair transplantation is not a highly regulated medical field. There are doctors who coin new terminology to promote their expertise. There are doctors that even claim that they were the ones who invented certain procedures by subtly changing minor details. It is alarming, but these things happen. To be fair, it happens in other industries as well. It is the basic theme of “buyer beware” that I often state in my posts here.

Your question on minaturization is an example of such variation in clinical practice. Hair generally loses its shaft thickness as it is lost. This thinning of the shaft is called miniaturization, a standard term in modern dermatology. Miniaturization occurs at different speeds in different areas of the scalp and over time it is (in men) often progressive. By getting a picture of the degree of miniaturization by area (a snapshot of the health of your scalp hair in each area), it allows the physician to determine not only the health of the hair in each paticular area, but it allows the physician the ability to follow the progression of the miniaturized process by area caused by the genetic process — or the improvement when a person is treated with drugs like Propecia.

Miniaturization measurements do not predict your future hair loss or the rate of that hair loss with certainty, because there are many factors involved in hair loss. It does give a trained doctor an extra set of vital information on the progression of the individual’s hair loss by monitoring and quantitatively documenting the effectiveness of medical treatments such. There is no science or measurement in when a doctor runs their fingers through your hair. Contrary to popular belief, mapping for miniaturization is often used to deter what is going on and allows the doctor to refine the diagnosis. Women have unique miniaturization patterns that differ from men and men each have different miniaturization patterns depending upon the extent and speed of their hair loss. Men who are not balding should show no miniaturization present (see example here).

With respect to body hair transplants, I am fully aware that there are internet advertisements and post-operative pictures with doctors proclaiming success. My reservation is that pictures do not always tell the truth. You need to meet these patients face to face and see their results and see the scars from their donor sites. At NHI we have monthly Open House events where we encourage all potential patients to come and see actual patients and learn and see a real hair transplant surgery. Furthermore, body hairs grow at different rates and have different (longer) dormant cycles where its transplantation may not be of clinical benefit (see Transplanting Chest, Leg, and Thigh Hair). Finally, hair transplants and even body hair transplants will NEVER restore your hair back to its childhood densities. It may be hard to believe, but you only need about 30 percent of your original hair density to preserve the same appearance.

Shock Loss and Hair Transplant in Women – Hair Loss Information – Balding Blog

Dr. Rassman, I am now just over 8 weeks post-op (1,600 grafts). I am “not quite sure” about shock loss. I seem to have an area that seems thinner than it used to be before the HT. How do I know it’s shock loss? Will it get worse? Why do I still feel stubble (grafts) on my scalp?

Thanks very much.

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From the name you gave, I gather you are female. If that is true, you can expect that some or all of the hair loss may reverse in 4-6 months, even if it is transplant shock from the surgery. Best to speak with your doctor and bond with him/her.

Hair Loss InformationNerve Damage in Donor Area From Face Lift Causing Hair Loss? – Hair Loss Information – Balding Blog

I had a face lift in Aug. 2005. By his own admittance, the doctor has damaged nerves behind my ears and neck area. In addition, my healing has caused keloids, which he cleaned up once in April, but re-healed the same. I have had, and still am having a lot of hair loss.

Has the nerve damage caused less blood to flow to the scalp?

The damage has caused numbness, a sense of cold, and a sense of ‘strangling’ in my neck. I’m not sure if this can be re-paired?

The main question has to do with hair loss.

Thank you.

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Your problems are clearly not simple and therefore I would require an examination of you with and would require more detail in your history. Keloids in the scalp are very, very rare. Nerve injuries should not impact blood flow to the scalp. Stick with your doctor if you believe that he/she is competent and has your best interests at heart.

Hair Loss InformationIf My Brother Is Balding, Will I Go Bald? – Hair Loss Information – Balding Blog

So Im 25 and I am not losing my hair (yet) but my dad does not have much hair left and so do all of his brothers. On my mothers side, 3 out of 4 of her brothers have that same problem. My brother is one year older than me and has already been losing his hair for a few years. Does all of this mean I will lose my hair sooner than later..if one brother is losing his hair, what are the chances of of the other not losing his. Also, I was wondering if men that have more body hair(chest+legs..) than the average guy has necessarly more testosterone in his body than average. I have a hairy chest and hairy leg but my beard is scarce(patchy) and it will not grow over 1.5cm, does that say anything about my testerone level or is it just random gene stuff. Are hairy men more likely to lose their hair. Also, is having fine/thin hair(not thinning) linked to more fragile roots and hair loss. Thanks you for your hepl in answering these questions, I have searched everywhere for answers and the few studies conducted on these subject that i found did not were not very clear. Thanks again

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Head hair loss does not follow body or beard hair genetics. Also, just because there are other balding men in the family line, you might just miss it. At age 25, if you do not have any hair miniaturization on your head, it will be likely that you will not follow your family pattern.

Why is a Hair Transplant Permanent? – Hair Loss Information by Dr. William Rassman

I would like to know how a hair follicle falls off. I was told that as DHT accmulates at the bottom of hair follicles hair falls off. This DHT is produmed by male harmones. Is this true? If this is the case even after hair transplantation DHT will be accumulating and it will cause the transplanted follicle to fall off. Then how is hair transplantation a permanent solution?

This is a good question. When hair is made by the body, it goes through many stages — from a single microscopic cell to a complex hair organ which contains hair, glands, nerves, blood vessels and muscles. Some people have genetic defects in some of their hairs on their head and men with male pattern balding have such defects in hair that correspond to the patterns of hair loss that they show. These defects do not allow the hair to grow from its single cell form into this complex organ which each hair follicles becomes. The defect is ingrained in each hair follicle that is impacted and it is never ingrained in hair follicles in the side and back of the head. As the transplanted hair comes from the sides and back of the head, the defect for making the hair fall out is not present in these follicles, so the transplanted hair grows. The hormone DHT causes the hair loss when the defect is present, but the hormone DHT does not affect the permanent hair from the sides and back of the head.

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Not Enough Donor Hair for Transplant – Hair Loss Information by Dr. William Rassman

I do not have donor hair (enough) for a trnsplant what would be my next option. currently, I am using a hair system with HMW. I find it to be quite expensive and there times when you still feel uncomfortable when it needs to be replaced. I would like to find a new alternative which would make me comfortable and make me feel connected to my hair:-)!!! What is the next best thing to a transplant. Why cant’t human hair be sewn into my scalp, just looking for solutions that I can still treat wash hopefully will grow like human hair.

First, have you had your head mapped out for miniaturization? What is the donor density? What is the laxity of your scalp? Do you have Diffuse Unpatterned Alopecia (DUPA)?

These are the questions that I would want to know to determine if you have enough donor hair for a transplant. Even the baldest of men (Norwood Class 7) can get great results from proper distribution if there is adequate supplies (see Patient ZU).

Alternatives may mean that you get less than a full head of hair. A thinner look can work for many people. Better coverage in the front at the expense of the crown can also work for the very bald person without enough donor hair. You should come to one of our Open House events to see some patiens with these alternative approaches. At these events we have some patients who choose to be thin either because of donor supply limitations, very fine hair or just limited budgets. Some choose to transplant the front and spare the crown. At these open house events we try to give our guests the opportunity to see a wide sampling of what hair transplants do and how normal people deal the the decisions involved in the process. It is important to think of the hair transplant doctor as a partner working with you to maximize your the value of what he/she can do for you.

Is Very Fine Hair More Likely to Develop MPB? – Hair Loss Information by Dr. William Rassman

I have a typical maturing hairline for a 21 year old. However, I’ve always had very fine hair. (the diameter of the individual hair is thin but I have a lot of it) Does fine hair mean I’m more likely to develop male pattern baldness or is the hormonal process that causes balding completely separate?

No. A person with fine hair is not more likely or less likely to develop balding than a person with a coarser hair.