Notes from the ISHRS 2009 Conference, Part 2

ISHRS 2009I just got back from the 17th annual scientific ISHRS meeting (basically a hair transplant doctor’s convention), which went on from July 22-26. Lots of information was presented… lots of lectures, presentations, and discussions. This year’s meeting was in Amsterdam, so I had quite a long flight back to California when it was all over and I was able to do a write up on the plane of what I learned. I thought I’d share…

If you missed yesterday’s post, check out part 1 of my ISHRS meeting notes! Here’s part 2…

 

Surgical

 

Hair transplant failures:
Hair transplant failures are often due to undiagnosed scarring (cicatricial) alopecias, so the need to detect them is critically important in advance of the procedure. The skin is often white and shiny and their activity may be in spurts, active at some times and inactive at other times. In my opinion and from my experience, women suffer more undiagnosed scarring alopecias than men and reflecting abnormal patterns of balding may be a clue to their presence. The doctor usually makes the diagnosis when these abnormal balding patterns appear and then the doctor will take multiple skin biopsies in the identified areas. Biopsies are the traditional approach, but the tissues that are taken for biopsy must have some active disease going on to affirm a diagnosis. When the biopsy approach to diagnosis is made, they are made with sizable tools (usually a series of 4 mm punches along the edge of the abnormal balding pattern). Alternatively, test transplants (which are limited procedures) can be done to see if growth occurs at 6-8 months. I have been performing test transplants over the years in such suspicious cases, as this is a more certain way of making the anticipation of success or failure of a traditional hair transplant. Failures of transplants in patients with such scarring alopecias are common.

Hairline design:
This is an area that I find most interesting. My philosophy is very different than most other doctors in the field. I tend to place hairlines in the mature position while most other doctors place the hairlines higher with more recession. There is a belief by many doctors that eventually a traditional mature hairline normally found in a non-balding man will not look normal as a man ages, so the hairline designs offered by many of my colleagues leave portions of the Norwood Class 3 and 4 frontal pattern into the end design of the hairline. Most men, however, want the man that they see in the mirror to reflect the mature hairline, not an “older” looking hairline, so I recommend the mature hairline almost all of the time. This is easily seen at our monthly open house events or online in our Hairline Photo Gallery. As my design of a hairline differs from many of the designs of my colleagues, the art form of a hair transplant surgeon will be evident to all.

Graft trimming:
Graft trimming by the surgeon and his team seems to reflect the robustness of the hair growth. A study was performed by Dr. Michael Beehner, where he trimmed the grafts from chunky to very skinny. The grafts that were made very skinny did not grow as well as those grafts that were made more chunky with more fat surrounding the hair grafts. Dr. Beehner believes that making grafts very skinny seems to:

  1. Open them up to the damage from drying and being out of the body for any prolonged period.
  2. Critical elements of the growth centers where stem cells exist, may be trimmed away during graft preparation.

New Hair Institute has always produced chubby grafts for these obvious reasons giving us a good growth track record. There is a direct relationships between the size of the graft and the ability to make recipient sites and place them well. The need to match the graft thickness with the recipient site holes are critical for good graft stability and growth.

FUE:
Four devices were shown to improve the FUE (follicular unit extraction) process. Each claimed that their product was the only one that worked. Every one had a mechanical rotation associated with it one with vibration, others with partial twists of varying diseases. Costs for these devices run as little as $60/each for a disposable device, to as high as possibly $200,000 for robotic controlled FUE soon to be available on the market. Clearly when there are so many options offered, the suggestion is that none really work well. Time will tell which are the best instruments by next year’s ISHRS meeting in Boston.

Saturday morning held a series of sessions called “Breakfast with the Experts”. My session on FUE seemed to have the highest audience. The concerns by the participants were the wild and unsubstantiated claims in performing high numbers of FUEs in a single procedure and a very unrealistic view of damage to the FUE graft from transaction and stripping the grafts in the process of extracting the grafts.

Wound closures:
Would closures from strip surgery were discussed in great detail by many doctors, each promoting their own prejudices. There was clearly no technique that was better than others to prevent scarring. Suggestions on trichophytic closures were one of the few bright spots, but the differences in the techniques used by the various doctors, in my opinion, ranged from effective to completely ineffective. In other words, getting a trichophytic closure is no guarantee of a great result from the technique and a trichophytic closure in one doctor’s hands may be a radically different technique than the same procedure in another doctor’s hands. Results ranged anywhere between wonderful and a complete failure.

Notes from the ISHRS 2009 Conference, Part 1

ISHRS 2009I just got back from the 17th annual scientific ISHRS meeting (basically a hair transplant doctor’s convention), which went on from July 22-26. Lots of information was presented… lots of lectures, presentations, and discussions. This year’s meeting was in Amsterdam, so I had quite a long flight back to California when it was all over and I was able to do a write up on the plane of what I learned. I thought I’d share…

 

Treatments

 

Dutasteride:
Review of the Korean study for this drug indicates that it is safe and effective drug with side effects consistent but slightly higher than those in the finasteride study. The tests, however, did not study the impact of this drug on sperm count. One doctor present at the meeting reported two patients who had become sterile while on the drug (one being his son). Both men, upon stopping the drug, found their sperm count returned to normal. The failure to study sperm count is, in my opinion, a major oversight in the Korean study from a safety point of view. Based upon this private report, I will not prescribe dutasteride without at least 2 years of treatment on finasteride or a frank failure of the finasteride. I will require that anyone getting a prescription from me (each case would be individualized) would have to sign a legal document that states they recognize that sterility is a possible side effect and risk of the drug.

Finasteride:
Finasteride limits Type 2 receptors for 5 alpha reductase, which reduces the incidence of cancer of the prostate… not the risk of developing prostate cancer. The information available only covers a 7 year period and longer term studies are not available. It is unknown if this drug will reduce the risk of prostate cancer.

PRP:
The use of platelet rich plasma (PRP) was a theme for many scientific papers. We have known that for topical use on skin wounds, this PRP has shown value in accelerating healing when applied. Studies for its application for alopecia areata was suggested by one doctor and a few doctors have started to soak the grafts in the plasma of patients to see if the grafts grew sooner, looked more robust and had a high “take” rate. I would not trust the conclusions of these doctors without a good scientific study to back up their observations. For the moment, I would call this “human experimentation”.

Prostaglandin:
Dr. Bessam Farjo presented a paper on prostaglandin receptors in the stimulus of hair growth. The drug latanoprost has been successfully used to grow eyelashes and is now FDA approved for this (in the form of bimatoprost), but the actual mechanism for what has been observed is unknown. It clearly increases the hair length, rate of hair growth and pigment in the treated lash, and there is a suggestion that there may be applications of this drug in the treatment of hair loss with a bit more research. Some early research by Dr. Farjo suggests that this may very well work as a stimulant for hair growth and in future treatments for hair loss.

 

General

 

Female hair loss:
One paper by Dr. Neil Sadick showed a finding in over 80% of women with hair loss that suggested an autoimmune type of process may be in play. He suggested that the exact cause of this autoimmune reaction may be a reaction induced by some unidentified triggering event. We have seen types of microscopic findings in such diseases as coronary artery disease which may have initially been triggered by some infection in the plaques found in the wall of the arteries. The suggestion is that it is this inflammatory process which is causing narrowing of the coronary arteries. If Dr. Saddick is correct, hair loss may be amenable to treatments similar to those offered from diseases like systemic lupus.

Hair growth cycle:
Dr. Dominique Van Neste gave the most significant presentation of the meeting, by developing a way to follow the growth of human hairs over days, months, or years. Using sophisticated computer imaging and analysis software, the entire life cycle of many hairs can be seen from their earliest appearance as a thread of hair arising from a new anagen part of the hair cycle to a mature terminal hair and then through the loss of the hair from the beginning of the telogen and shedding process. With these tools, the impact of drugs like minoxidil or finasteride can be shown modifying the hair cycle. What has been shown is that new hairs rarely arise from drugs like finasteride or minoxidil, but that the impact on the hair thickness and the rate of hair growth may reflect the changes the naked eye sees. This tool has great promise in testing multiple herbal products on the market (probably hundreds of natural based products) that are found in fruits and vegetables. Claims on the effectiveness of such herbal products can either become validated or put to sleep once-and-for-all.

HairDX:
HairDX, through Dr. Sharon Keene, will produce a pilot study to determine the connection between the gene found on the X chromosome in females and the CAG repeat score suggesting the sensitivity to blocking the androgens when they are positive for genetic balding. The arguments are two fold:

  1. Does the female who is balding have a androgen mediated disease (abnormality)? If that would be the case, then drugs like finasteride (in these women) may be effective for the treatment of balding. In the various studies with finasteride, the results varied widely.
  2. For those women who are CAG repeat positive (suggesting that this subset of women may get a good response from the treatment of DHT blockers like finasteride), will the use of finasteride actually help them with their hair loss? This will be an ongoing study over the next few years.

 

Read Part 2!

 

I did not wash my hair since the FUE 2 weeks ago, how do I wash it?

I am shocked that your doctor never explained the washing process to you. The recipient area requires daily washes to keep it free of crusts. I generally recommend the use of a sponge and supply my patient with a surgical sponge to fill with soapy water and press on the recipient area daily. By repeating this daily, all crusts can be washed off without any fear of losing grafts. If any crust are present, use a Q-tip and dip it into soapy water then roll it on the crusts. That will lift them off without dislodging them but never rub them, just roll the Q-tip on the recipient crust. I like to see no evidence of any crusting in the recipient area and the crusts from the donor area gone in 7-10 days with daily washing.

Not the Role of Testosterone and DHT

Hello, I have a curious question regarding the medication finasteride for male pattern baldness. I visit your balding blog website, and noticed how amazing and smart you are when it comes to propecia. I have a question

Im curious when the testosterone increases from finasteride if it can speed up hairloss in the frontal area? So propecia could in theory speed up frontal hairloss while slowing down vertex/crown hairloss? Propecia also permanently increases receptor areas for dht? So in reality propecia could make hairloss worse it is possible?

I do not believe you analysis is correct. DHT blocks the 5 alpha reductase enzyme production which causes the hair loss in genetically prone men.

I am finding that there is a trickle of these types of questions. Propecia (finasteride) is prescribed for slowing down genetic androgenic hair loss. It does not cause more hair loss. I do not know why there is a belief that testosterone causes frontal hair loss. On men who take finasteride, they still produce healthy amounts of testosterone. Sometime, the testosterone levels increase when a person is on the drug finasteride.


2014-08-15 08:46:18Not the Role of Testosterone and DHT

Not Taking Finasteride and Dutasteride

I’ve been taking a 5ar inhibitor for the past 8 years, both dutasterdie and finasteride. I am now short on the medication, and, as I move to California, I think that I will run out for a few weeks. Will that be ok? I’ve never missed a dose before.

The drug Finasteride stays in your body for up to a week in the hair follicles, while Dutasteride is certainly longer than that. I don’t understand, however, why you would not just take the pills with you and keep to a schedule. Be responsible about your hair loss.

 


2018-08-17 09:24:25Not Taking Finasteride and Dutasteride

Not Sure If I’m Losing Hair from MPB or From Significant Weight Loss

I am a 24 year old male who has lost a lot of weight in the last 8 months. I feel like my hair is thinning but am not sure. I haven’t noticed any excessive shedding, my hairline is the same, but my hair does feel a little thinner. I’m not sure if it’s due to weight loss or the beginnings male pattern hair loss (my family does have a history of it).

My question is would it be bad to get on Propecia now even if I am unsure as to whether or not i have male pattern baldness? and if i’m not balding would it be bad to start taking propecia for preventative measures? i.e. If I start propecia can it jump start male pattern balding?

and do you know of any places in Sacramento that do the miniaturization test?

Weight loss produces dietary problems which can cause hair loss, particularly if you are genetically prone to it. Genetic male pattern baldness (MPB) is the most common cause of hair loss or hair thinning in men. It occurs special “patterns” — as the term implies. If you have MPB, any good dermatologist can diagnose this problem and prescribe you Propecia (finasteride 1mg) as an option. Only a doctor can prescribe you Propecia. Propecia does NOT jump start hair growth from male pattern baldness. It slows it down as a rule.

Not-normal SMP

This is the second time I have seen this type of SMP done on the head and I suspect that maybe these men actually want to look like this. This is not in my playbook.


2020-07-21 08:14:13Not-normal SMP

It’s Not Healthy to Be a Night Owl and Stay up Late at Night

According to a New Scientist, Article 21, April 29, 2018, Northwestern University in Chicago reported that “People who prefer to stay up late seem to have a greater risk of dying early. A six year study of 500,000 people in the UK has found that those who are night owls were 10% more likely to die in that period.”

In this group of night owls, they also “found higher rates of diabetes, mental health problems and neurological conditions. They were also more likely to experience psychological stress, use drugs or alcohol, and not get enough exercise or sleep.”


2018-10-23 09:51:27It’s Not Healthy to Be a Night Owl and Stay up Late at Night

I Am Not Happy with My 1000 Grafts Done 1 Year Ago

Based on your report, 1,0000 grafts is not a large number and the number of grafts may not have been enough to fill in the recipient area. As you did not show the pictures taken before the surgery, I can not tell you for sure.

Expectations are clearly established between you and your doctor at the time of the surgery. Go back and revisit that previous conversation with your doctor.


2018-06-21 09:20:58I Am Not Happy with My 1000 Grafts Done 1 Year Ago

Not Hair Loss News – Walnuts Appear to Improve Semen Quality

Snippet from the article:

Healthy young men with a Western-style diet may be able to boost their sperm quality by eating a small packet of walnuts a day.

These are the findings of a new study that shows healthy American men in their 20s and 30s who ate a 75g (2.5 ozs) packet of walnuts a day were able to increase the vitality, motility and structure of their sperm compared to counterparts who did not eat walnuts.

A report on the study appeared online on 15 August in the Biology of Reproduction journal’s papers-in-press section.

Infertility and subfertility is a common problem that affects about 70 million couples worldwide. Between a third and a half of cases are due to poor semen quality in the male partner, with scientists giving a number of reasons for this in industrialized societies: pollution, unhealthy lifestyles and the Western-style diet cited amongst them.

Read the rest — Walnuts May Improve Sperm Quality

The study included 117 men (between 21 to 35 years old) and was partially funded by the California Walnut Commission.