Effectiveness of DHT blockers

My question is; does finasteride and dutasteride lost effectiveness over-time in the body? Like, say in decades, would my body become used to dutasteride and it will lose its effectiveness and hair loss will resume or can I preserve my hair forever (until I’m a senior, theoretically) just from taking 0.5 mg of dut everyday for the rest of my life?

Another question, will the hairs that grew back become thick like how they were before they fell out? Is there anything I can do to make them thicker or do I just have to keep taking the drug and wait longer?

It is not the blood levels of these drugs that are important, but the tissue fixation that occurs after taking the drug. The tissue fixation of finasteride is about 7-9 days while the tissue fixation of dutasteride is about 6 weeks. These drugs generally do not lose effectiveness but the balding pattern is tied to apoptosis (cell death) which these hairs undergo over time. These drugs slow the process down but will not prevent the outcome, which is inevitable.

In the early stages of use, when miniaturization is high and newly formed, the probability that these drugs will reverse the miniaturization process, making these hair stronger and less miniaturized, will be good.

Ecrinal

I started to loose some hair. I decided to buy some shampoo against hairloss and i found one at the pharmacies called ecrinal. On the box it says that it contains ingredients of lipidic nature that come from a gland located at the base of horses’ mane…tricholopids and A.N.P. So i’m wondering if this shampoo may actually be effective?
Thanks.

Mister EdFirstly, please see my previous post about Mane-Tail-Groom. There appears to be considerable support for this product in Europe. But that product is for horses and some humans use it on themselves — what you’re asking about is a shampoo for men and women that has an extract from a horse mane, right?

Dr. Pak first reviewed your question and in researching it, it was obvious that he knew nothing about this family of products and he wrote: I do not know of any “tricholopids” or “A.N.P.” (I don’t even know what that stands for). Furthermore, I am not a veterinarian and don’t know what relevance a horse’s mane has to do with human hair growth. I am curious what would make a horse’s mane better than that of a lion, perhaps? Or what about a hairy monkey? More importantly, how did they get these “glands”? How many horses’ glands were sacrificed for the sake of hair? I wonder what Pamela Anderson would say as the spoke person for PETA.

I think Dr. Pak has a humorous writing style, so I thought I’d try get a smile from you by posting his response. The serious answer to your question is — I have no idea.

Eating nuts can cut your risk of heart disease and stroke

People who regularly eat nuts have a reduced risk of cardiovascular disease (CVD) and coronary heart disease (CHD) when compared to people who rarely or never eat nuts, according to a study published Nov. 13 in the Journal of the American College of Cardiology. This study was done after up to 32 years of follow-up and the researchers assessed the associations of total nut intake and the consumption of individual nuts with CVD, CHD and stroke risk. CVD and CHD included a combination of MI and stroke, but CVD also included all forms of cardiovascular-related death. People who ate one 28-gram serving of nuts at least five times a week cut the risk of cardiovascular disease (CVD) by 14 percent and the risk of coronary heart disease (CHD) by 20 percent when compared to people who rarely or never consumed nuts.

Eating Dairy Makes My Scalp Ooze

Anytime I consume dairy products especially milk and butter and sometimes ice cream,(yogurt and cheese do not bother me), I start getting a secretion on my scalp within a day or so and it hardens while trapping the hairs on the scalp. It is almost like putting gum or glue on the scalp. I wash my hair every day and sometimes I can dig my fingernails into this stuff to try to get it off my scalp but then tons of hair come off with it. Polysorbate 80 works great for eliminating this stuff but I have avoided consuming milk and butter for well over 10 years and that works better. I also notice that by just being overweight(even without consuming milk or butter), I am afflicted with this problem so I have slimmed down. I would like to know what is this stuff that forms on my scalp and why does it do that in the first place?

Maybe you should not consume dairy products at all. Perhaps switching to soy will be a solution. I couldn’t tell you why the sebum output on your skin/scalp seems to be stimulated by the dairy you consume. With regard to polysorbate, Wikipedia says:

“Polysorbate 80 (commercially also known as Tween 80, a registered trademark of ICI Americas, Inc.) is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid, and is often used in foods. Polysorbate 80 is a viscous, water-soluble yellow liquid.”“Polysorbate 80 is often used in ice cream to prevent milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, to hold air in the mixture, and provide a firmer texture, holding its shape as the ice cream melts.”

Thanks for the interesting question.

Eating Chocolate Reduces Heart Attacks and Stroke Risks by 25%

Eating chocolate may stave off cardiovascular disease
APAJun 18, 2015648 views

British study finds that regular consumption of chocolate could reduce risk of heart disease and stroke….
Scientists at the University of Aberdeen analysed data of 21,000 participants in the EPIC Norfolk study as well as literature covering chocolate and heart disease. Average chocolate consumption came to seven grams per day, consumption ranging from no chocolate at all (around 20 per cent) to 100 grams per day. 14 per cent of the participants experienced heart disease or stroke during the 12 years the study ran…. Those with the highest daily consumption still showed a 23 per cent reduced risk of stroke. These results held true not only for dark chocolate but also for milk chocolate.

That will be good news for many of our readers who are lovers of chocolate.

Early sign of frontal balding (photo)

It’s been getting worse and worse over the past few months. Under certain light i can already see my scalp there Did the hairs that were there fall or are they just extremely thinner? I want to get on Minoxidil asap but im really afraid that the initial brutal shed people talk so much about, destroys my frontal hair line even more… Now i get why they tell you to get on something asap…

The erosion of a thumb-print section of hair loss from the frontal hairline suggests early frontal balding may be starting. The best approach is to find a doctor who can do a HAIRCHECK ( https://baldingblog.com/haircheck-test-how-it-is-done-video/ ) test on you to see if there is balding anywhere on your head. You need a Master Plan for what may happen to you and a good doctor should work with you to form such a plan if your hair loss is worse at any time than you realize. Yo should recognize the importance of your problem, address it professionally so that you keep your hair on your head as you get older no matter what happens to your potential balding.


2021-05-12 14:11:21Early sign of frontal balding (photo)

Early Diagnosis of Alzheimer’s Disease

The following report came from the Alzheimer’s Association International Conference (AAIC) 2014 by Medscape Medical News: “A Simple Eye Tests to Detect Alzheimer’s Disease in the Works”

COPENHAGEN, Denmark — Two novel, noninvasive, and relatively simple eye tests show promise as potential screening tools for early Alzheimer’s disease (AD).

“Preliminary results from 2 studies presented here at the Alzheimer’s Association International Conference (AAIC) 2014 show that beta-amyloid detected in the eyes significantly correlated with the burden of beta-amyloid in the brain, allowing investigators to accurately identify individuals with AD

In the first study, researchers at the Commonwealth Scientific and Industrial Research Organization (CSIRO), Australia’s national science agency, used curcumin fluorescence imaging to highlight beta-amyloid in the retina and correlated these results using Pittsburgh compound B (PiB) positron emission tomography (PET) imaging findings in the brain.

“Every single person who tested positive with high levels of plaque in the brain tested positive to the retinal test as well, so we had 100% sensitivity and no false negatives, which is a crucial component on a screen for Alzheimer’s disease because we don’t want to leave anyone behind when it comes to the early signs,” lead investigator Sean Frost said at a press briefing here.

This is a very important medical breakthrough as Alzheimer’s disease (AD) will impact tens of millions of Americans in the future, possibly your own family. There are strong suggestions that changes in lifestyle (diet, regular daily exercises, no smoking) can reduce the timing of these changes and possibly reduce the incidence of this disease in the tens of millions of people who are highly likely to get it.

Early crown loss, what should I do?

Could you give your opinion on how i can treat my thinning thinning? I’ve always had thin hair but the crown is noticeably thinning i think. I’ve always had a widows peak even from an early age but i’d expect it may be very slowly increasing in size over time also but it’s hard to say. It may be worth noting but i currently only use Nizoral anti dandruff shampoo in my hair every 3/4 days and that is what has provided the best results for my scalp which used to get dry and itchy. I very rarely apply any product into my hair because of the same dryness/itchiness also.

Your hair loss, if significant, is very early. I wonder if you should do anything about it. Maybe minoxidil liquid applied to the crown is the most benign approach and finasteride for the frontal hairline. The enlarging Widow’s peak suggests that your hairline is moving upwards, maybe just maturing but that is the reason to see a specialist in this area.


2019-04-08 12:46:14Early crown loss, what should I do?