Drug-induced Hypertrichosis

The pathomechanism for omeprazole-induced hypertrichosis is not known. Omeprazole significantly increases duodenal prostaglandin (PG)E2 synthesis and elevates the expression levels of cyclooxygenase-2 protein and PGE2. Prostaglandin F2 alpha analogues, such as latanoprost, can increase pigmentation, thickness, length, and number of eyelashes. Prostaglandins are involved in hair growth regulation; PGE2 and PGF2 alpha stimulate hair growth, whereas PGD2 has an inhibitory effect. It has been suggested that a balance between PGE2 and PGD2 controls hair growth in mouse and human skin, whereas drugs that stimulate hair growth may exert their effects by acting on prostaglandin pathways. It has been suggested that minoxidil increases production of PGE2, and topical cetirizine, which has been reported to be beneficial in androgenetic alopecia, decreasing inflammatory cell infiltrate and PGD2 production. Prostaglandins may have an action on hair growth regulation through their vasomotor effects in the dermis, inducing blood flow in the perifollicular vessels, and by inducing DNA replication and stimulation of cell division and growth.

There is a solution in this disease because vellus hairs are turned into real terminal hairs. Can it be identified?


2018-06-19 08:57:46Drug-induced Hypertrichosis

Drs Rassman and Pak Take Propecia

I just have a quick question,

I know that both you, and Dr. Pak have used, respectively, several of the treatment options that you recommend. Why don’t you use before and after pictures of yourselves to disarm the pessimists, while at the same time making a very compelling case as to why you feel so strongly that finasteride is the strongest treatment option available at this time?

The only oral medication that has been FDA approved for treating genetic balding in men (androgenic alopecia) is Propecia. So as the default, I guess it is the “strongest” medical treatment option at this time. This does not mean it will reverse or cure balding. In fact there is no cure! We are physicians. We prescribe medications based on scientific evidence as well as clinical evidence we see day to day. In the end the consumer (the patient) has the choice to take this medication, but he should consult with the prescribing doctor instead of strictly reading Internet postings that may (or may not) be true!

As you mentioned both Dr. Pak and I have personally taken Propecia daily (as well as our family members and friends) without any of side effects. Neither of us has seen dramatic hair growth, but we haven’t seen dramatic hair loss either. In the end, you are looking at the after pictures (on the right). Ultimately though, we cannot satisfy everyone. If you think something bad will happen, then it just may. The power of suggestion can be quite powerful. If you think the medication will not work, then its your choice to simply not take it. We’re talking about hair loss here, and as important as hair is to many men, it isn’t a death sentence if left untreated. We’re educating and informing about a proven treatment and I’ll leave disarming pessimists up to the drug manufacturers.


2009-03-10 10:53:37Drs Rassman and Pak Take Propecia

Drinking Fruit Juices with Propecia?

Hi Dr. Rassman,

This news story recently came up and I was wondering if it at all pertains to Propecia? Do fruit juices hamper the effect of the pills or does Propecia work no matter what it’s ingested with? Thanks for your time and consideration.

Taking pills? Lose the juice and take with water to ensure absorption: study

It has been known for some time that grapefruit juice can decrease the effectiveness of certain drugs. I do not believe Propecia is one of them, but if you are concerned, then simply do not take Propecia (finasteride 1mg) with grapefruit juice. The article does do a good job telling you when grapefruit juice is a problem.

Dreadlocks and hair loss

I am white female in my early 30’s. I had dreadlocks for 10 years and cut them off because of the same problem, the twisting and weight was too mich and caused permanent damaged.
I loved my hair it grew down my calves and to cut it was a hard decision. I cut them 7 years ago and the problem has not gotten better. Now i have thin hair and very little my hair line is higher and higher every year…it could maybe just make 1 lock. I lost hope. Traction alopecia seems not to have any cure coming up soon since they scalp hets scarred and the follicules are lost. I don’t know what to do, I wear wigs now without it I look 20 years older because of my hair loss. I loved my dreads and I hate to say they destroyed my hair.

Hair transplants are another alternative that you might look into. It requires a visit to a hair transplant doctor like me to determine if you are a candidate for this type of procedure.

 

Dreadlocks Causing Hair Loss in Woman?

I have a dear friend, young, beautiful girl (caucasian) who has come to believe that her really long dreadlocks – which she has been growing for 7 years…is causing perhaps permanent bald spots on her scalp. She is really beside herself about it, and wondered what she could do to be sure, and if so – to cure the problem.

Dreadlocks can produce traction alopecia (hair loss from constant pulling). The best thing for her to do is to get rid of them and then wait for recovery of the hair. After 7 years, the hair loss may be permanent, but until the pulling stops, you will not know one way or the other. Recovery from traction alopecia may take up to a year.

Dreadlocks cause balding (photo)

This is an example of a man who is balding and is making it worse by wearing a dreadlocks hairstyle. He would be better off shaving his head to preserve his hair than by pulling it out and getting traction alopecia from this hairstyle.


2020-09-01 09:48:52Dreadlocks cause balding (photo)

Forget Stem Cell for Hair! Here Is Dr William Rassman’s BioTech Video Created For A Shark Tank Interview

When Dr. Rassman is not busy inventing hair transplant related devices and procedures, he runs a company called Mavenbiotech.

He will summarize the label-free imaging technology for measuring biomolecular interactions in a microarray format by using a video with ping pong balls to illustrate how antibodies work. Dr. Rassman believes that this technology will change the timeliness of medical care delivery

For those who cannot wait, skip to 4:50 on the video.

Dr Rassman’s Willingness to Show Opposing Opinions

Doc,

I brought up my questions about the value of miniaturization studies which you responded to. Though I’m still not convinced, you posted a response from another doctor who also questioned it’s value giving his reasons. Your willingness to post those suggests you’re a true scientist. People often portray science as consensus when it’s just the opposite. Those who claim any debate is over are restricting knowledge not expanding it.

Thanks for you’re continued effort to expand all of our knowledge.

Sometimes the opposite opinions are from people who completely made up their minds and there’s nothing I could possibly say that would make a difference. This is my blog and the readers are generally a bright group who come here for answers and insights, and that is why I love doing this. Teaching is my responsibility to give back what I have learned over the years to those balding people. Thanks for your comments.