Is DHT and 5 Alpha Reductase Related to Its Receptors For Male Pattern Balding Catastrophe?

so dr? i interpret from your blog that 5a reductase is responsible for MPB and sensitivity of the receptors have nothing much to do with such catastrophe?

Male pattern balding MPB is not a catastrophe. It is the cards that we are dealt when we are born just like the color of your eyes, shape of your nose, or the way you look. As stated in numerous posts, GENETIC inheritance is responsible for male pattern balding.

One of the mechanism of this genetic predisposition we know of is dihydrotestosterone (DHT). There may be other mechanisms other than DHT but it has not been discovered.

Scientists have found that if you block DHT, male pattern balding can be altered/ halted/ slowed/ temporarily reversed. Male pattern balding is not curable but it can be managed with drugs or surgery.

Blocking DHT is accomplished (as we know it) by slowing down the production of DHT. This is accomplished by inhibiting an enzyme called 5a reductase. 5a reductase is responsible for producing DHT from Testosterone. I suppose there may be another way to block DHT by blocking the receptors for DHT (not the enzyme that produce DHT). This will be new type of drug – yet to be discovered. Another drastic way to address MPB is castration to stop most of the testosterone production thus stopping most of DHT production but this will be drastic.

My point here is that it isn’t about DHT or 5a reductase. It is a genetic issue. So for those looking to completely block DHT with stronger medication such as Dutasteride (Avodart), it does not work as one may hope. Mainly because (I say again) it is a genetic issue. Another way to put it is that if you do not have the genes for MPB, you can have a very high DHT level and you will not be bald.

DHEA and Hair Loss

Hi,

I have read confilicting information regarding DHEA supplements and Hair Loss.

  1. Can DHEA increase hair loss?
  2. Is this due to DHEA converting to Androstenedione then this converting to Testosterone and then on to DHT which causes the hair loss?
  3. Does DHEA cause direct problems to the hair follicles like DHT does?
  4. If you were to take a 5 alpha Reductase inhibitor like Finasteride would this help with any potential hair loss problems associated with taking DHEA? and if so would it be because it blocked the Testosterone (converted from the Androstenedione converted from the DHEA) from converting to DHT?

Thanks for your help

  1. Dehydroepiandrosterone (DHEA) does not directly cause androgenic alopecia (AGA), but may accelerate it.
  2. DHEA can potentially affect DHT levels, thus indirectly causing hair loss (via DHT).
  3. Dihydrotestosterone (DHT) does cause hair loss in men who are genetically susceptible to AGA.
  4. Finasteride is a prescription medication for men who have AGA. It is not meant for use with DHEA.

I Have Been Developing These Yellow Bumps on My Head, Every Other Day and Then They Pop and Go Away. (Photo)

After a hair transplant, some people develop these yellow pustules as a reaction to the retained hair spicules in the scalp left over from the transplant. These spicules are a foreign body, so your immune system isolates them and pushes them out by draining them. If you only have a few once in a while as you said, it is best treated with warm soaks. This will cause the pustules to ‘pop’ open and drain spontaneously. This problem rarely occurs after the first 3 months following a hair transplant.

pustule1

Developed a New Bald Area After My 3500 Fue Hair Transplant

The pictures show that you were probably thinning in the area that is now devoid of hair, so the cause is likely due to the progression of the hair loss into the sides. Another hair transplant into this area will solve it; however, be careful that your doctor does not over-harvest your donor area or you will have a new problem – a see-through donor area with possible donor site depletion as shown many times in the RealSelf posts. Your donor density must be close to its harvested limit with an FUE procedure (assuming that you had an average donor density prior to your FUE transplant) so a strip surgery may be safer. You should make sure that your surgeon measures your donor density prior to making the recommendation for FUE or strip surgery.

progressive hair loss

I Have Developed Lumps in My Donor Area 1 Month After My FUE

These lumps may be caused by buried grafts that were pushed under the skin of the donor area at the time the FUE was done. These, if they get infected or are painful, should be excised surgically. Here is an example of buried grafts that was removed after an FUE was incorrectly performed. If you look carefully at each lump, there are hairs and grafts inside the lumps.

ingrown or buried grafts

I Developed a Large Scar After My Strip Hair Transplant, Why?

Scars like this are usually the result of an overly aggressive surgeon who removed a strip too wide, and the tension may have been too high when he closed the wound. Alternatively, a very elastic collagen is present in some people which can produce stretching of the wound. In this case, the wound reflects your genetic make-up with regard to the way you heal. The best treatment for this is Scalp Micropigmentation (see here:https://scalpmicropigmentation.com/scar-covering/). Sometimes, with scalp exercises, you can loosen up the scalp enough to try to get the scar removed. During that time, the surgeon would perform a trichophytic closure which will help obtain a better scar. If your scalp is not loose enough, a surgery will not work.


2018-07-18 13:09:06I Developed a Large Scar After My Strip Hair Transplant, Why?

Developed Facial Swelling from Propecia?

hiya i was taking propecia last year for about 6 months and it was great. i started again very recently and i’ve deleloped swelling in the face of my skin, i have stopped now. i’m just wondering if there is anything i can take that can counteract that and be able to still take propecia because it worked so perfect a such a long time before?
thankyou

I have never heard of Propecia causing facial swelling, but drug allergies sometimes present that way. It can happen with any medication. Facial swelling can sometimes be related to tongue and throat swelling, which may be life threatening if the allergy presents in its worse form. While life threatening issues from the use of Propecia (to my knowledge) have never been reported, it is still a remote possibility. And with only the information you provided without a physical exam and complete medical history, it is impossible to give you any advice other than to see your doctor and share these concerns with him/her.


2007-07-24 13:33:21Developed Facial Swelling from Propecia?

I developed a bald spot over the past 2 weeks, what could this be?

This bald stop, if only 2 weeks old, should be examined by a dermatologist. The dermatologist will look for Exclamation Mark Hairs, which might point to alopecia areata as a diagnosis. Maybe it is possible that you have had this for some time and just noticed it which then could be male pattern balding’s first presentation


2019-04-01 10:53:52I developed a bald spot over the past 2 weeks, what could this be?

Determining Future Hair Loss

Hi Dr. Rassman. I am 22 years old but have been experiencing hair loss since I was 13. I have already tried Minoxidil (1 year) and Propecia (1 year) when I was 14-16 without stopping or slowing hairloss. I haven’t really lost much confidence due to my hairloss but it is very notorious now and would definitely like to do something about it. From what I can tell baldness comes from my dad’s side of the family (grandfather and father plus many of my dad’s cousins went bald) but no one has gone bald as young as I have. I think I am a class 3A Norwood and have been thinking about getting hair transplant surgery but I am worried if I will have enough of a donor area to cover the bald spot once the balding process stops, especially if I bald like my grandfather but so far it doesn’t seem to be the case. I was just wondering if at this advanced stage it was possible for a doctor to determine how much hair I will have left.

You need to have a good doctor define what is going on with your hair. Hair loss at 13 is rare, but can occur. If genetic balding has started that early, it would have been good to get a base line on the degree of miniaturization and the change over time. You must have that done now, before you get worse, or you will not know where your hair loss is going. With your history, a densitometry examination with quantification of the miniaturization in each area of your head will point to the long term pattern of your genetic hair loss (assuming that this is the correct diagnosis). There are other conditions as well, so it would be of great value to you to have a consult with someone like me, who is familiar with the causes of hair loss.

Transplantation in a person with certain conditions could be contraindicated. You need to be evaluated by a professional and even sending photographs will not give me the detailed microscopic examination I need. Please do not become your own doctor. This is not a game, but your future look we are talking about.


2005-07-20 12:43:00Determining Future Hair Loss