Concealers, Two Great Products: Toppik and Dermatch (from Reddit)

This is an extensive overview of two great products for men and women who need to camouflage their hair loss. The products are very different in the way that they are used.

From my patient population over the years, I found that each person has his/her favorite. https://www.gll-getalife.com/the-best-hair-loss-concealers-toppik-dermmatch-results

 


2018-06-21 13:23:17Concealers, Two Great Products: Toppik and Dermatch (from Reddit)

Computers Causing Hair Loss?

Hi doctor I have three major concerns:

  1. I have been using Tricovivax (“Minoxidil 5%”) for about two months and I have noticed a massive rate of hair fall, shedding, and thinning. Even my family members are telling you are starting to have bald spots in your head.
  2. I am very concerned with thinning at the back of my head (donor) are and when my doctor mapped my hair for “Miniaturization” noticed that my donor area is thinning too; and he applied the “pull test” and noticed a large amount of hair being pull.
  3. Is setting long time at the computer screen during work will accelerate my hair loss since the computer screen emits radiation?

Thanks a lot doctor

I am pleased to hear that you have had a miniaturization study done. By your brief description, you may have a condition known as DUPA (diffuse unpatterned alopecia) or chronic telogen effluvium. Using drugs such as minoxidil or finasteride may not help in these cases. You need to follow-up with your doctor for options, diagnosis, and treatment. Sounds like he started off by taking the first correct steps.

Sitting at a computer screen will not cause hair loss.


2007-05-22 13:33:28Computers Causing Hair Loss?

Computer Imaging for Balding Patients

Dr. Rassman:
Do you use computer imaging with your patients, to manipulate a current patient picture into a “target goal” picture? I did not see any info about this on your website, but it certainly seems to me the best way to ensure both patient and doctor share the same vision. Thank you.

We have been offering open house events for 14 years so that prospective patients can see, first hand, what the actual results are from hair restoration surgery. The use of computer imaging is frequently misleading, just as photography can be, because it shows what the operator wants to show and does not take into account the real elements that make ‘coverage’ for hair replacement surgery. Things like hair thickness and hair character can not accurately be portrayed with computer imaging. The view can also be misleading. Frontal views, for example, are often better than top views for showing more fullness.

Setting patient expectations is at the core of what I do. I have written extensively on the artistic elements in the hair restoration process and published these observations in prestigious medical journals and text books. I do not believe that correct expectations can be set by the imaginary world created by computer images. As a side note, although many doctors do computer imaging, few will give the patient a picture of what they might look like from such imaging systems. The reason is simple: such a picture is like a contract, which can be used in court against the doctor if the result in that picture is not obtained. If the correlation between computer generated images poorly defines the differences between projected results and the actual results, then this tool does not set proper expectations for the bald buyer. It is clearly better when you examine a person up close, who has actually had a surgical hair restoration procedure and holds his ‘before’ picture for you to examine with his ‘after’ presence in person.

This computer imaging is vastly different for a nose job where a nose is altered in length, or taking out a bumb. A breast augmentation is also a simple computer image to demonstrate because size and location with support or poor support is easly altered on the computer as it would be in surgery. Most patients who show at the open house, will let you feel the thickness of their hair and then you can compare your thickness with theirs. In addition, the hair character (curly vs straight) will be evident. You can look from many views, even the worst view so that you absolutely know what will happen to you. What you see is going to be what you are going to get.

Hair is very different and that is why we rely on the open house format. I do not want to mislead anyone.

Compounding my own finasteride vs oral

I have no idea if compounding finasteride myself is the way to go and if it does anything. The only objectively sure thing is that I have experienced no side effects so far. But I also have no results in the 3 weeks since I started this self made drug and it is a real hassle making it myself.

Maybe with no results, what you did to make your own topical finasteride is not working. There is a reason that compounding pharmacies do this, they have expertise that you don’t have


2021-07-15 06:46:51Compounding my own finasteride vs oral

Complications of minoxidil

Dr. Rassman in your practice have you ever had a patient with an adverse reaction to oral min? Thanks so much!

Yes, some people can’t tolerate this medication for one of many reasons, and the blood pressure effects can be disabling for a few people, with lightheaded and rapid heart beat. Here is a list of some of the side effects of minoxidil. Some of these side effects only relate to the topical application of minoxidil.

  • Fluid retention
  • Facial hair growth
  • Fast heartbeat
  • Hair shedding
  • Irritation
  • Nausea
  • Acne
  • Burning of scalp
  • Chest pain
  • Fainting
  • Headaches
  • Application site redness
  • Difficulty breathing
  • Hypertrichosis
  • Redness
  • Swelling of face
  • Breast tenderness
  • Burning
  • Low blood pressureReddened skin
  • Weight gain
  • Hair texture changes
  • Heart palpitations
  • Cardiac Tamponade (very rare with a lot of early signs of it but potentially deadly)

Complications of Mesotheray (Photo)

Multiple injections into the scalp caused multiple abscesses and hair loss. Make sure you get to see an experienced doctor and not some unskilled doctor who is in the hair filed in it to make a buck! You may pay more heavily than with money for terrible work.


2020-04-19 09:41:49Complications of Mesotheray (Photo)

Comparison between topical and oral minoxidil (publication)

I find that the conclusions offered are not justified by the content in the following ways:

  1. The authors mentioned that oral minoxidil was superior in the crown.
  2. No blood levels were measured for the topical minoxidil; however, systemic symptoms were found, suggesting that considerable minoxidil was absorbed through the skin into the body, so men without the enzyme that converts minoxidil to minoxidil sulfate in the scalp (the active form of the drug), which is absent in 60% of men, still got systemic benefits from the topical minoxidil.

This leads me to conclude that 60% of men without the active enzyme in their scalp who were treated with topical minoxidil received systemic minoxidil through the skin.

William Rassman, M.D.

Original Investigation
April 10, 2024

Oral Minoxidil vs Topical Minoxidil for Male Androgenetic AlopeciaA Randomized Clinical Trial

JAMA Dermatol. 2024;160(6):600-605. doi:10.1001/jamadermatol.2024.0284
Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia

Key PointsQuestion Is oral minoxidil effective in treating androgenetic alopecia in men compared with topical minoxidil, 5%?

Findings In this double-blind, placebo-controlled randomized clinical trial including 90 men with androgenetic alopecia, daily oral minoxidil, 5 mg, was well tolerated and did not demonstrate superiority over topical minoxidil, 5%, in men with androgenetic alopecia after 24 weeks of treatment.

Meaning Low-dose oral minoxidil (5 mg per day) had similar efficacy to topical minoxidil, 5%, for men with androgenetic alopecia and can be an option for patients who prefer oral therapy or are intolerant to topical treatment.

 

Abstract

Importance There has been increased interest in low-dose oral minoxidil for androgenetic alopecia (AGA) treatment. However, the efficacy of oral minoxidil for male AGA is yet to be evaluated in comparative therapeutic trials.

Objective To compare the efficacy, safety, and tolerability of daily oral minoxidil, 5 mg, vs twice-daily topical minoxidil, 5%, for 24 weeks in the treatment of male AGA.

Design, Setting, and Participants This double-blind, placebo-controlled randomized clinical trial was conducted at a single specialized clinic in Brazil. Eligible men with AGA aged 18 to 55 years classified using the Norwood-Hamilton scale as 3V, 4V, or 5V were included and randomized. Data were collected from January to December 2021, and data were analyzed from September 2022 to February 2023.

Interventions Participants were randomized 1:1 into 2 groups: oral minoxidil, 5 mg, daily and topical placebo solution; or 1 mL of topical minoxidil, 5%, twice daily and oral placebo for 24 weeks.

Main Outcomes and Measures The primary outcome was change in terminal hair density on the frontal and vertex regions of the scalp. The secondary outcomes were change in total hair density and photographic evaluation.

Results Among 90 enrolled participants, 68 completed the study; of these, the mean (SD) age was 36.6 (7.8) years. A total of 33 participants were enrolled in the oral minoxidil group and 35 in the topical treatment group. Both groups were homogenous in terms of demographic data and AGA severity. For the frontal area, the mean change from baseline to week 24 between groups was 3.1 hairs per cm2 (95% CI, ?18.2 to 21.5; P?=?.27) for terminal hair density and 2.6 hairs per cm2 (95% CI, ?10.3 to 15.8; P?=?.32) for total hair density. For the vertex area, the mean change from baseline to week 24 was 23.4 hairs per cm2 (95% CI, ?0.3 to 43.0; P?=?.09) for terminal density and 5.5 hairs per cm2 (95% CI, ?12.5 to 23.5; P?=?.32) for total hair density. According to the photographic analysis, oral minoxidil was superior to topical minoxidil on the vertex (24%; 95% CI, 0 to 48; P?=?.04) but not on the frontal scalp (12%; 95% CI, ?12 to 36; P?=?.24). The most common adverse effects in the oral minoxidil group were hypertrichosis (22 of 45 [49%]) and headache (6 of 45 [14%]).

Conclusions and Relevance In this study, oral minoxidil, 5 mg, once per day for 24 weeks did not demonstrate superiority over topical minoxidil, 5%, twice per day in men with AGA.

Trial Registration Brazilian Registry of Clinical Trials Identifier: RBR-252w9r

Comparison Between Finasteride and Dutasteride

Note: Article Warns of Variations in the Quality of These Drugs on the Market

Pharmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteride

in Journal of Molecular Endocrinology

Human steroid 5 alpha-reductase type II is a prostate-specific, membrane-associated enzyme that catalyzes the conversion of testosterone to dihydrotestosterone, the most potent androgen in the prostate gland. Genetic variants of this enzyme have been associated with both the development and the progression of prostate cancer. Both finasteride and dutasteride are competitive inhibitors of the type II steroid 5 alpha-reductase that have been effectively used for the treatment of benign prostatic hyperplasia. Finasteride has also been successfully utilized for prostate cancer chemoprevention. We here investigate 5 alpha-reductase inhibition assays in vitro to measure the effect of incubation time on the apparent inhibition constant (Ki) for both constitutional and somatic (prostate cancer) enzyme variants. Our systematic pharmacogenetic analysis shows that both finasteride and dutasteride are slow, time-dependent inhibitors of steroid 5 alpha-reductase type II, and that the inhibition kinetics depend on the 5 alpha-reductase genotype. We also show that, overall, dutasteride is a more efficient steroid 5 alpha-reductase inhibitor than finasteride. Based on our data, we are able to map areas of the enzyme that are responsible for this time-dependent inhibition for either (or both) enzyme inhibitor(s). This comprehensive pharmacogenetic analysis of steroid 5 alpha-reductase variants unveiled significant pharmacogenetic variation for both finasteride and dutasteride and thus should be taken into account when designing protocols for treatment and/or chemoprevention of prostatic diseases with either one of these 5 alpha-reductase inhibitors since there is considerable pharmacogenetic variation for both drugs.


2020-02-22 12:20:03Comparison Between Finasteride and Dutasteride

Comparison Between Diffuse Thinning Believed by Man and His Normal Hair on the Same Man (Photos)

I zoomed in on the thinning that this man believes he has. Some of the questionable miniaturized hairs have been identified by me, but the percentage of miniaturized hairs is less than 20%, which means that this is not thinning in the medical diagnostic sense.

Zoomed in picture on the left


2020-06-04 18:27:48Comparison Between Diffuse Thinning Believed by Man and His Normal Hair on the Same Man (Photos)