Dr. Rassman,
DHT type II is found predominantly in hair follicles
DHT type I is found predominantly in the skinDo you know if the inhibition of DHT type I can negatively impact the rate of skin aging? Pseudohermaphrodites offer a good biological modelf for type II deficiency, and I haven’t heard that they age any differently than men with normal hormonal profiles. But what about type I deficiency? Are you in contact with any dermatologists who might know about this, or at least have a theoretical response?
There are drugs that block both type I and II DHT, but they do not impact skin and aging. Biochemistry and the most logical scientific reasoning and models do not always correlate with what we observe. Blocking 100% of DHT (type I or II) does not stop or reverse hair loss and a 100% block of DHT is unlikely from a practical point of view.
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What percentage of Type II does Propecia block, if it’s known? I was always under the impression that b/c it was a DHT blocker it blocked 100% of DHT! If blocking 100% of DHT does not stop or reverse hair loss, what the hell stops or reverses hair loss, blocking 12 or 35% of DHT? And when people grow back hair, this seems to indicate that DHT is indeed blocked 100% and is reversing itself! This all seems contradictory!
And this whole Type I DHT is really confusing as hell! If it’s DHT, why doesn’t Propecia block it and some other drugs block both? Does this mean Propecia is not the most effective drug out there?
Lots of questions here but this posting troubled me a bit.
What do you make of the link below? This doctor (who developed a topical testosterone cream) says Propecia will def. adversely affect muscle growth b/c it affects binding at the cellular level.
http://www.maxmuscle.com/index.cfm?fa=article&doc_id=43&subcat=basic_nutrition