Month: January 2023

This is an interesting new approach to hair loss. We need to wait to see the FDA safety and effectiveness studies on this compound.

Mystery compound found to be safe and effective at treating hair loss. Details in comments. from tressless

It’s good to see a man discuss his experience in managing his hair loss. Nice job!

Hilarious video!!! I am not sure if his methods are actually legit but dude in video is cool in a weird way… from tressless

These are very rare and require that the surgeon, when they are present and the area is going to be transplanted, reproduce this double whirl. Most people have a single whirl either on the left or right side of the crown. Take a look at yours.

This young man is enrolled in University of California in San Diego and has a career in Physics in front of him. He is very bright and he is balding already, now only in the crown, but he has early thinning evident in the frontal corners which may follow his father’s pattern of a Class 6 balding pattern.

He said, point blank, that he did not want to go through the four hair transplant surgeries that I did on his dad, even though, he admitted, his dad looked ‘good’. He was dead set against Propecia, for sound, rational reasons and understood clearly, that the decision not to take this drug would inevitably lead him to continue with the progressive balding process he is presently experiencing. He came to this decision having thought hard and long, and after doing considerable research on the subject. “My body has its own clock and my unique genetics and I have known this since I turned puberty. I fully realize that I am ready to go bald, if I must, but I don’t want to keep worrying about it, day in and day out. Now, I live under a base ball hat and I want to go out not worrying about my hair and my visible aging, balding head”

So he came to see me because he decided to have Scalp Micropigmentation. We discussed his changing natural hairline that may disappear with time, and he fully realize that the hairline that we will create with SMP will be permanent and that he was willing to accept the normal recession and adjust his styling, possibly locking in a short hair style (almost shaved look) for the rest of his life. He wanted for us to create a natural shape and configuration of a youthful hairline that he saw on our website on some of our hair transplant patients and on some men who shaved their head and never went bald. I told him that for a while, he will be able to let his hair grow out, until the frontal hairline recedes. He didn’t mind and liked the idea that once he had the SMP done, he would be finished with his hair problem and go on with his career as a physicist and focus on the rest of his life.

I like the density count in the article which does show an increase in hair density following PRP. More data and more patients are required but the study is good.

file:///Users/nhi/Downloads/sjy029%20(1).pdf

https://www.nature.com/articles/s41598-020-80624-3.epdf

This article is highly technical and discusses hair cycling and identified some of the mechanisms for this process.

https://sci-hub.cc/10.1016/j.bbrc.2016.02.099

There are several other publications also on sulforaphane, an isothiocyanate which has been extensively studied in relation to the hair follicle as well as other systems (such as cancer prevention): Example: Sulforaphane (SF maintains HF proliferation and active hair growth (anagen) during oxidative HF damage (Haslam et al. 2016). This compound is present in broccoli and can be found in tablet form sold as cancer preventative, increasing energy etc. I’m surprised no one is selling it yet to promote hair growth. In the meantime tell everyone to eat broccoli! (comments by Nilifer Farjom MD)

This is a highly unusual persistent frontal juvenile hairline with balding behind it on the left and a patient with parts of his juvenile hairline on the left. The surgeon who saw this patient suggested that his lower remnant hairline be removed with a laser and the new hairline be placed where he drew it on the man’s head on the left.

The patient on the right, had his hairline created about 1 inch above the remnants of his juvenile hairline. I do not agree with this strategy but you can see the grafts. When these grafts grow out, he will have the remnants of his juvenile hairline evident. I would transplant the entire frontal hairline, retaining the juvenile hairline within my hairline design and restore his juvenile hairline.

These men had a look which has always been with a low hairline and they would most likely want to retain their original look. Doing laser removal will not work 100% so these man will end up having a half dozen laser procedures over a year to get out maybe 95% of these frontal hairs removed and never get where they want or need to be so that would not a good decision.

Cell. 2015 Apr 9;161(2):277-90. doi: 10.1016/j.cell.2015.02.016.
Organ-level quorum sensing directs regeneration in hair stem cell populations.
Chen CC1, Wang L2, Plikus MV3, Jiang TX4, Murray PJ5, Ramos R3, Guerrero-Juarez CF3, Hughes MW6, Lee OK7, Shi S8, Widelitz RB4, Lander AD9, Chuong CM10.
Author information
Abstract

Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regeneration of up to five times more neighboring, unplucked resting hairs, indicating activation of a collective decision-making process. Through data modeling, the range of the quorum signal was estimated to be on the order of 1 mm, greater than expected for a diffusible molecular cue. Molecular and genetic analysis uncovered a two-step mechanism, where release of CCL2 from injured hairs leads to recruitment of TNF-?-secreting macrophages, which accumulate and signal to both plucked and unplucked follicles. By coupling immune response with regeneration, this mechanism allows skin to respond predictably to distress, disregarding mild injury, while meeting stronger injury with full-scale cooperative activation of stem cells.

I have not personally seen such responses, but I will reach out to my colleagues and ask for their opinions. I already had a response from Dr. Bernstein in New York when asked about pucking, said: “No… I’ve been plucking for years – and look where it got me.” Dr. Bernstain has a Class 6 balding pattern as you can see on his informative hair restoration site here: https://www.bernsteinmedical.com/