Author: Dr. William Rassman

I, like another member on here recently, was prescribed Finasteride in the 5mg tablet once a week by my dermatologist. I’ve researched here that it’s better to take it daily for the most effective treatment, however, the pills that I picked up at the pharmacy are very, very small. They are circular shaped, blue in color and have an ‘H’ on one side, and a ’37’ stamped into the other side. Are you guys familiar with this pill and is this the size that I am expected to cut into fifth’s?

I need to know if I should try and get a larger size, go ahead and cut them (into at least thirds?), or just stick with the once a week treatment. Thank you!

This is a problem that I’ve heard about before, depending on the generic maker. I’m not familiar with that exact pill you’re describing though. Some generic makers use various excipients to size the pill larger, making it easier to cut. Some may even add scores into the tablet to make it easier to break. You can either go back to your pharmacist and see if they have a different generic size available or try to cut the pill carefully.

It really makes no difference if the 5mg pill breaks apart, provided that the entire 5mg pill is consumed over a 4 day period. I am assuming that even with some crumbs lost in the cutting process, it will still amount to 4mg consumed. Taking 1mg every day is better than taking 5mg once every 5 days, but I’m not your prescribing doctor.

Is it true that Finasteride in Humans would reduce important Neuroactive Steroids like for example allopregnanolone? I know there was already a post about this in the past but that was about rats. In rats, Finasteride blocks both type I and II 5α-reductase whereas in humans inhibits only type II which it seems is not present in the brain unlike type I. I would appreciate your opinion about the following two studies:

Link 1: Finasteride Treatment and Neuroactive Steroid Formation (PDF file)

Link 2: The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

I do not think I can add much here, as I am not a biochemist. Mood changes have been associated with finasteride and depression has been reported, but I’m unclear on specifics beyond that.

The 1st link is a study of 20 men with an average age of 69.5 years that took 5mg finasteride. The 2nd link is a study of a dozen men that took the 1mg finasteride with no listed ages that I see. Both studies are small and offer nothing definitive, using words like “probably” and “might”.

This should go without saying, but finasteride is an elective medication with some rare side effect possibilities and is available by prescription only. Hundreds of other medications also come with side effect risks, and you must talk with your doctor about these risks and benefits so you can make an informed decision.

Could you tell me more about Laminins-511 please and whether you think it is a promising ‘solution’ to hair loss? I had never heard of it before reading this article, but i’m now very intrigued.

Link: Mens Health

I do not know much about laminin-511 besides this press release from 2008. These are studies performed on mice and the research is disseminated to the popular media, grabbing the interest of readers such as yourself. I don’t see a date on that article, but I’m guessing it was from back when the laminin-511 mouse findings were first announced. It says they’ll have trials in 2 years… so I’d assume there should be info already if it was successful, but I can’t find anything new.

These news stories create a definite interest, but the implications on hair loss treatment remains to be seen. We get these types of stories sent to us almost on a weekly basis.

First of all thank you for what you do with this site it is a tremendous resource. I am twenty and began to recede at the hairline about a year ago. I started taking one fourth of a proscar daily in April without a prescription and got a prescription for it in June after seeing a dermatologist. I have since been taking the generic version daily. The medication does not seem to be working as I have continued to lose much hair from my crown to the point where my scalp is visible in harsh lighting.

I have long hair but i have noticed in the last week that I am losing the very short (terminal?) hairs again after not noticing them for the past few months. Could this be due to the switch to the generic version? The proscar pills were individually sealed while the generic are together in a pill bottle could this air contact affect their potency? As it has been seven months and I have lost noticeably more hair should I discontinue the medication?

Thank you, my dermatologist is pretty clueless when it comes to hair loss, so I appreciate your knowledge.

Generic finasteride 5mg is the same drug as Propecia, which is just finasteride in 1mg strength, so there should be no difference in efficacy. I don’t think bottle vs individually sealed has any bearing on the potency.

Finasteride does not work that well for frontal hairline, so what you may be experiencing is just your normal course of hair loss that the drug cannot address. Harsh lighting will make the hair appear thinner. Do you have comparison photos to look at from before you started? You’ll need to discuss changes to your medication with your prescribing doctor.