Hair Loss Gene Regulation from Environmental Influences? – Hair Loss Information – Balding Blog

Hi Doc,

Firstly thanks for the blog, very helpful and informative, have been following it for some time.

I had two questions for you,

1) First is regarding propecia. I have read many entries in your blog and you mentioned that complete reversal is extremely rare and usually seen in those under 21 (with use of propecia). My question is within your practice have you ever seen early to late norwood 3 patterns reverse to a norwood 2 (where balding is hardly evident). I know that regrowth is rare and should not be expected, but was just wondering if you had seen such changes in your practice.

2) You and other doctors (experts in hair loss) have mentioned that even if one is carrying a baldness gene it doesn’t necessarily manifest itself. Well I know that gene regulation causes genes to turn on and off during ones lifetime. Could it be possible for the baldness gene to turn off once it has manifested due to positive environmental influences (healthy diet, very low stress, exercise etc..)…my second question is just me wondering really, medically it might not make much sense, but I have heard of gene regulation (genes turning on and off during ones lifetime due to environmental influences) and was thus wondering if this applies to balding genes as well.

Thank you

Block Quote

What more can I say about complete hair loss reversal from Propecia other than it is highly unusual.

There is little doubt in my mind that the balding gene has on and off switches that may be impacted by environmental factors such as diet, but I do not know what many of them are. I do know that stress is one of those environmental factors that can impact balding. As more research is done, we’ll continue to learn more.

I’m Seeing Results After 2 Months on Propecia – Hair Loss Information – Balding Blog

Hi doc

I’ve been taking propecia now for 2 months and starting to see good results,

But I’ve read that people shed hair before you see results? I’ve shed no hair what so ever. Is that good or bad?

Thanks for your help and advise this site has been very helpful

Block Quote

Shedding isn’t that common after starting Propecia, so what you’re seeing is not a rare occurrence. Stick to your plan and congratulations on your early success!

Hair Transplant Failures – What Could Cause the Grafts to Not Grow? – Hair Loss Information – Balding Blog

I’ve been writing about hair transplant failures more and more on this site lately, because it is a growing concern. I have been seeing, on average, 1 patient per week (from outside my office) who had a hair transplant with a significant failure of the grafts to grow (greater than an 80% failure).

I just saw another patient who had received over 2000 grafts a few years ago. He was not a happy camper. There was very little growth and he had a very detectable scar which did not allow him to cut his hair short. He had such high hopes that the new hair from the transplant a few years ago would solve his image problems, but after much consternation and considerable anguish, he found that his situation was worse off than if he never had any procedure at all.

The patient explained that he did not like his doctor’s lack of concern in addressing the failure of his transplants to grow nor the detectable scar that plagued him every day. He was disappointed that his research on this particular doctor left no clue to the quality of this doctor’s work, nor his indifference to his plight. Before the surgery, when the doctor’s team “sold” him on the transplant solution, the environment was welcoming… but after the grafts failed to grow, he did not feel welcome by that particular doctor as he was made to feel that the failure of the transplant was his fault, not the doctor’s problem.

This particular patient had as much focus on his scar as he had with the failure for the transplants to grow, because he had the same look from the front and top view as he had before the surgery. He had no deformities from the surgery and his recipient area healed well with no scars present.

So what could be the possible causes for a failure of transplants to grow?

I should start off saying that I have never seen the cause of the problem stemming from something the patient did or did not do. Many of the patients who come to see me because their transplant did not grow felt that they were responsible for the failure. I think that patients feel that the surgery is a mysterious process and that there must be something wrong with them.

I have seen problems appear with graft growth in some women, as they may have had an undiagnosed condition called diffuse alopecia areata as a cause. Sometimes there may be problems with the recipient area skin (e.g. blood supply or scarring). That being said, most failures reflect surgical factors that are within the scope of what the surgeon and his team control.

Quality control means closely monitoring the activities of each and every staff member in the hair transplant process. Most of the failures reflect a failure of one or more of the following:

  • Graft drying: exposure to air for more than 10-20 seconds can kill the graft. The smaller the graft, the greater the risks for graft damage or graft kill. This risk occurs at many times in the procedure: (a) immediately after graft removal, the grafts are not immersed in a bath of a physiologic solution, (b) during graft trimming, when the grafts are optimized with regard to the size, (c), during movement of the graft from one place to another, (d) during placing, when the grafts are held in the air for more than 10-20 seconds.
  • Graft storage: The solutions used contribute to the survival of the graft and the longer it is out of the body, the greater the potential damage. This risk reflects upon the skill of the surgical team and the experience of each technician.
  • Graft handling: Managing the movement of the grafts from the physiologic bath solution to the recipient area takes time. Some doctor’s assistants who place the grafts will pile them up on the finger or hand, leaving them exposed to air for more than 20 seconds.
  • Graft placement: This requires a special skill that often takes more than a year to acquire. Often it reflects a talent. The grafts must be delicately handled, because crush injuries are a potential problem.
  • Graft depth: There is such a thing as a graft that is placed too deep or too superficial. Too deep can kill the graft as it turns the graft into a foreign body. It can also produce pimples or folliculitis sometimes weeks after surgery
  • Grafts destroyed or never done as claimed: For long cases, I am under the impression that some doctors and/or some of their technicians actually toss the grafts in the garbage because: (a) they were too tired, (b) the placing was too difficult, (c) they never harvested or placed the number of grafts that they actually charged for. All of these things probably happen far more often than anyone cares to admit, but because it is a financial issue, the doctor and/or the team gets greedy. That means that from some surgeons’ points of view the surgery is about money, not grafts… and certainly not results.

When I see claims of FUE or strip surgery in the numbers that some patients from other clinics tell me that they received, I know in my heart that it could be a scam. This, of course, is a felony, but how does anyone know it if it is not reported? I have been told by many technicians that these things happen at other medical offices where they worked. Once, I had a technician toss away some grafts in my own practice and I fired that tech on the spot. This problem is the most alarming of the problems in this industry.

When a surgeon and his/her team finish placing the grafts, violations to any significant degree of any of the above can result in placing grafts that were killed in the surgical process. The surgeon and the patient will not know if the procedure worked until 6+ months after the procedure was done. By that time, the patient’s check has cleared the surgeon’s bank account by the time he finds out if the surgical techniques worked out or if the patient was honestly delivered what they purchased.

Hair Loss InformationWould Mini-FUE Be Ideal for Treating Possible Triangular Alopecia? – Hair Loss Information – Balding Blog

Good day Dr Rassman,
I wonder if i would be an ideal candidate for your new FUE harvesting technique!

I have been in contact with you before. I am a 44yr old male with a small (1 inch) bald spot on my right side in front of the ear. i have never seen anyone else with this particular condition, i wonder if you have. i can resend pictures as no doubt you are unlikely to have the ones i sent to you some years ago. Hair miniaturised in this area probably at the start of my balding process (was gone by the time i was 30 i think). Many years of propecia and minoxidil have had no effect whilst they have had some effect on the top of my head.

A consultation with a dermatologist diagnosed triangular alopecia (although that was simply by looking and he may have just have piggy backed onto my suggestion that it was!!). A course of steroids both topical and injections have had no effect.

i wonder if this new technique could be the answer. My only concern is that if this is an immune system rejection of hair in that area, then i assume placing more hair there will be rejected as well but i am no expert just looking for a solution. many thanks

Block Quote

If you have a 1 inch area on one side of your head, a mini-FUE would possibly be ideal.

Before assuring your candidacy for surgery, I’d of course have to see precisely what you’re referring to and I’d want to know for sure what the diagnosis was. I don’t know why you’d think your immune system would reject hair transplanted into an area of your scalp.

Hair Loss InformationAvodart Dose for Male to Female Transsexuals? – Hair Loss Information – Balding Blog

Dear Dr., I am Male to Female Transsexual who’s been on (finasteride 5 mg, Spironolactone 100 mg, Estradiol and Progesterone) for 14 months now. I am 30 y/o, my body is responding well but my hair isn’t. I get some tiny hairs on my hairline but I loose them, I go through phases of shedding. Recently, I started to read a lot about Avodart but I am debating with my Dr. on the dose.

The 0.5 mg is not intended for Hair loss but higher doses are more effective. Is 1.0 mg better or shall I go with the 2.5 mg? Or is the 0.5 mg effective in my case since my T levels are low? I mentioned my case because my case is unlike any other cases, my body Chemistry is a woman’s but I did not have the Testosterone factory removed yet so I am pretty confused.

Please, I really need your kind advice. My Dr. is unfamiliar with Avodart and for financial issues, I cannot see anyone else. Thanks so much and kindly accept my gratitude.

Block Quote

I’ve answered a related question years ago — Transgender Male-to-Female Taking Dutasteride.

As you aren’t my patient, I am unable to give you specific dosing advice on how to use the various drugs which have an anti-androgen effect. This treatment for balding may not work at all if you triggered the hair loss when you had androgens working in your system. Avodart (dutasteride) may not reverse the hair loss, particularly since you’re looking to regrow the hairline, but it may slow down the loss process, possibly more than finasteride.

I have treated male-to-female transsexuals with hair transplants and provided that the balding pattern is not too advanced, the results are pretty good. I have not treated MTF patients with Avodart, though.

Off Topic — Water Wigs Photo Series – Balding Blog

Water wigsHey doc,
Have you seen these cool photos that have gone viral? A photographer made a series called “Water Wigs” where he used a high speed camera to capture water balloons bursting on bald heads.

The results are really really cool. here’s an interview with the photographer and some photos from the series.

Link: Tim Tadder’s Photo Series “Water Wigs” Captures Beautiful Intersection Of Baldness And Water Balloons

These are amazing photos by Tim Tadder. Very neat idea.




Related Posts Plugin for WordPress, Blogger...

Balding Forum - Hair Loss Discussion

Patient Results – 4149 Grafts Restored His Hairline (with Photos) – Hair Loss Information – Balding Blog

This patient with straight, medium fine hair had presented a Norwood class 3A pattern when I first met with him years back. His first hair transplant surgery was 1927 grafts, and while it gave him a hairline that he had been missing for years, he decided to have another procedure (of 2222 grafts) a year later to fill it out a bit more. No further procedures are planned.

Click the photos to enlarge.

After (4149 grafts total over 2 procedures):

 

Before:

 

Press Release – ISHRS Celebrates 20th Anniversary – Balding Blog

Snippet from the press release:

As the International Society of Hair Restoration Surgery (ISHRS) prepares to kick off its 20th anniversary this October with a look back at the significant improvements made in the art and science of hair restoration surgery, millions of men and women around the world have better hair to show for the tremendous growth in this specialized field of medicine.

“Over the last 20 years, the ISHRS has grown to over 1,000 international members working in collaboration to establish the highest quality standards and best practices that have led to the modern-day hair transplant,” said ISHRS President Dr. Jennifer H. Martinick. “Now, results are natural looking and virtually undetectable, and ISHRS members are committed to pushing new frontiers in scientific research to further enhance results and possibly even reverse or delay the onset of hair loss.”

Read the rest — 20th Anniversary of World’s Leading Hair Restoration Medical Society Spotlights Greatest Advances in Combating Hair Loss, Potential Future Breakthroughs




Related Posts Plugin for WordPress, Blogger...

Balding Forum - Hair Loss Discussion

Direction of Graft Growth – Hair Loss Information – Balding Blog

Hi Dr,

Can you explain how accurately a surgeon such as yourself can transplant grafts so that hairs grow in the same direction?

I have seen quite a few celebrity transplants where the hair still appears thin and the hair once grown out always looks messy because the direction of the grafts is not quite right.

How are you able to ensure that this doesn’t happen?

As someone with naturally fine and very straight hair then i imagine it would be essential that any transplant i had done should be performed by a top surgeon who is able to make sure that the angle of the transplanted graft is accurate. If i had thicker and naturally curly hair then i suppose this wouldn’t matter so much and is probably a part of the reason why those with curly make better candidates?

Thanks

Block Quote

Doctors have direct control of how the transplanted hair grows and how the transplanted hairs are distributed to give the most natural look. This is a very important point that most prospective patients do not take into account when searching for the right medical group for a hair transplant procedure.

You are correct in stating the fine straight hairs need careful attention to detail when undergoing a hair transplant procedure, but careful attention to detail is also a must for coarse hair, because each hair can have many times the bulk of a fine hair. A coarse hair put in the wrong direction will be more easily detected than a fine hair put in the wrong direction. Some surgeons, when placing the hairline, place the frontal hairs radially (like bicycle spokes). Is it possible that surgeons who do this do not understand the normal direction of the hair growth, just are ignorant of the facts? Sometimes I think so.

To be sure that these poor placement doesn’t happen to you, you have to do your own research and due diligence. There are many good doctors with great artistic skills. The best way to determine who these doctors are is to ask to meet some of their patients. My patients love showing off their results in the privacy of our office, so we set up circumstances once a month to allow this to happen. To me, this is just plain good medical education. This is why we have our monthly Open House events where anyone can come and see our former patients (up close) and speak with them face to face.

Teenage Acne and MPB? – Hair Loss Information – Balding Blog

Hi Doctors,

Do you believe that there is a link between suffering from acne in early teenage years and male pattern baldness? Being as acne spots are based around the hair follicles and hormones also have something to do with it, I am curious.

Thanks for looking at my question!

Block Quote

Changes in hormones are what is responsible for teenage acne and androgenic alopecia (AGA). In boys under 16, we rarely see patterned genetic balding being expressed, yet we see a great deal of acne in this age group. There is no direct linkage that I know of.