Propecia Questions, Part 2 – Hair Loss Information by Dr. William Rassman

Note: This is continued from part 1 that was posted yesterday …

6. I often hear you and others say that stopping Propecia will bring the user to his baseline ‘hair level’ had Propecia never been taken in the first place. This to me seems reasonable, and reassuring. However, I remain a bit skeptical because there is no conceivable way to test that claim. What if hair follicles lose some of their resistance to DHT, simply because they no longer have to deal with it? Is it possible that stopping the drug will make things worse than they would have been? The old “Use it or lose it” saying applies. And this concern carries over to using Minox as well. In case I’m not explaining myself properly, here’s a scenario to illustrate:
Step 1: DHT reaches hair ‘A’.
Step 2: Hair ‘A’ is not adversely affected by DHT.
Step 3: Start using Propecia (presumably to help hairs OTHER than ‘A’).
Step 4: Hair ‘A’ no longer has to ‘fight’ DHT.
Step 5: Stop using Propecia and DHT comes back.
Step 6: Hair ‘A’ is not “prepared” for the DHT onslaught (use it or lose it).
Step 7: Hair ‘A’ is destroyed. Hair ‘A’ would have been fine if Propecia was never used.

How could you say Hair ‘A’ was fine to begin with? The answer is not as simple as A+B=C There are many documented cases where people who gained hair from using Propecia, lost the gained hair when they stopped using Propecia.

7. Propecia has only been around since 1998, Proscar since 1992. So nobody has been on Propecia for more than 8 years. I’m wondering how many people will actually be able to maintain lifetime use of this drug. Unforeseen developments happen in people’s lives all the time, and this should be a pivotal consideration in deciding to go on the drug. Will some situation arise in life that will prevent me from continuing to use Propecia? It’s entirely possible. In your experience, are people able to maintain their use of Propecia, or do you find that people go off the drug at some point?

First, I agree being compliant with any drug therapy for life may be hard. It is definitely something you should consider before starting any elective drug therapy. Likewise, male pattern baldness is also for life. Furthermore, hair transplant is also for life. As you may be aware, these are non frivolous considerations. It is something you and your hair transplant doctor need to consider in making a “Master Plan” for your hair loss.

Second, Proscar is actually protective for prostate cancer.

8. I’ve read your comments in other threads that if a person does not trust the company or the FDA then he should not use their product. This sentiment is all fine and dandy, but things are ne’er so black & white. For instance, recent developments involving Merck & its drug Vioxx cast doubt on the trustworthiness of Merck. And yet that doesn’t mean that Propecia doesn’t work or that its true side-effects have been concealed. Basically I don’t see your point about trustworthiness. Companies have a mandate to increase profits. Sometimes that may lead them to be unscrupulous. Other times they may not need to resort to that. All we can do is ask people in the field, people like yourself, to give us first-hand accounts that will inform our own decisions.

I recommend Propecia to most of my patients with male pattern baldness because I have seen its results first hand. I also recommend Advil for most of my patients with simple arthritis pain.

9. Now, with regards to Minoxidil. I think the general consensus is that Minoxidil plays second fiddle to Propecia when it comes to effectivness. My question is, do you think that Minoxidil is good purely for maintenance, i.e. to prevent further hair loss? Or does the 3-15% statistic that you’ve quoted before apply again? My feeling is that if I go on Minoxidil, eventually I’ll move on to Propecia, so why even bother with Minox in the first place? And there’s something disconcerting about the scientific community not knowing how Minox really works.

You seem to know the answer to this question already!

10. Are Minox & Propecia useful for people who experience what I would call ‘age balding’? That is, people who simply lose a little bit of hair every year throughout their life as part of the regular aging process. Skin doesn’t stay pristine, bones & ligaments don’t either, so should people who don’t experience classic MPB go on these drugs simply to have a fuller head of hair with time? I’ve seen pictures of you (a very handsome man I might add, hehe), and while you’re not bald, I’m sure your hair count is not what it was at 16. Nor do you seem to be suffering from classic MPB. Would you have gone on Propecia or Minox back then to stay looking younger longer?

I am on Propecia now and have been for many years. With regard to your fountain of youth, sorry but there is no such fountain available yet.

11. Personally, I’ve had good hair all my life. Recently, my hairline has matured, and is beginning to look much like my older brother’s. He’s 38, and has a full head of hair, with a widow’s peak (I have one too) and with a slight dracula syndrome (dracula hair with the triangle pattern) whereby there is some degree of temporal hair loss, what is normally termed devil’s horns. When my brother was younger, his hairline was much like mine (although apart from hair, our faces look quite different so I don’t know about relying on my brother’s genetics). He had a widow’s peak with no devil’s horns. I now have progressed to the stage of a low frontal hairline with devil’s horns on the sides just like my brother, maybe a little worse. I can also see the miniaturized hair on the skin where the horns are. If my hair were to stabilize here and progress the way my brother’s hair has, I’d be satisfied. But I don’t want to take chances. Am I wise to embark on this lifelong journey of drugs to prevent the possibility of further loss? I am now at a point where I feel that taking the drugs might restore some of the miniaturized hair, bringing me closer to my freakishly low teenage hairline. But am I being greedy here? These are questions I need to ask of myself, but it’s always good to benefit from the wisdom of others. I’m 23 years old. I do shed quite a bit, and I always have. But I’ve always seen that as a consequence of having a large hair count to begin with. Still, vain as it may be (and I wish I could get past the vanity), I want my hair looking good for as long as possible. But if my hair is not destined to get worse than it presently is, going on drugs would be a waste of money and time. Also, my hair itches often at the sites of hair loss. Moreover I don’t like washing my hair a lot, and I worry that Minox won’t be effective on an oily scalp. I like my scalp to be a little oily for styling purposes so I’ll shower every other day, or every other 2 days (I wash my body daily however). I’m looking for your advice, what you would do if you were in my shoes.

At 23 years old, you may be at the beginning stage of losing your hair. You need a good hair transplant doctor to evaluate the miniaturization process and map your hair loss. If your doctor recommends it, you should then be using any possible Propecia treatment. But with respect to your teenage hairline, I doubt Propecia can restore that.

12. What is the significance of shedding hair with the white bulb at the base, versus shedding hair without the white bulb? Just a general hair question.

The presence of a ‘white’ bulb at the end shows some mucus associated with the hair that you are looking at. Generally the presence of a complete hair follicle with or without a white mucus bulb is of little significance, provided that there are few. There is a specific test that determines to which degree hairs will come out when pulled upon. Normally, only a few hairs will come out of a group of hairs that are pulled upon. What a pull test will show is that if a large percentage of hairs that are pulled upon come out, then some disease process may be going on.

I hope that everything was answered to your satisfaction. If you have more questions, please feel free to comment or contact me.

Hair Loss Treatments and Cures in the Future? – Hair Loss Information by Dr. William Rassman

What hair loss treatments and cures can we look forward to in the future? When will these treatments be ready for use?

There are many drug presently working their way through the FDA. I have become aware of two of them recently, but have signed non-disclosure agreements so I can not identify them. The mechanisms of how they work out seem to be different than the drugs that are available today, but great clarity in their mechanism of action will take time to define. Drug testing can take between 5-10 years.

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Problems from Fincar (Generic Finasteride) – Balding Blog

Dr. Rassman: Fincar Caused Bizarre Problems for me-please advise. I have used 1/4 proscar daily for 8 years I decided to try Fincar for a while. Supposedly Fincar is identical to Merck’s proscar. After starting Fincar my left testicle started aching. I had read numerous about such a paid although I had not experienced it.

In 30 days of Fincar use, bare spots appeared in my beard and the hair on my left arm diminished significantly. The outer third of both eyebrows have thinned drastically and my skin has gotten dry and wrinkly. I know this all sounds crazy but it’s scary.

I went to my family doctor and he just blew me off and said Im getting old since I’m 48.

Doctor-What did the Fincar do to me? I’ve been of Fincar 3 weeks. No testicle pain. Will I return to normal? I’ve resumed the Merck proscar daily but am scared. I wish I had never touched Fincar. Please tell people to never touch the non-Merck finasteride.

Thanks

From my understanding finasteride formulations like Propecia and Proscar is still under U.S. Patent protection thereby restricting the manufacturing of this drug in companies which are under patent treaties with the United States. Generic versions of finasteride like Fincar are made by a pharmaceutical company called Cipla in India and is not available in the U.S. (although I suspect internet sales makes this possible). I am not familiar with International Patent laws so I am not qualified to comment on patent issues. I do know that foreign manufacturing of drugs are not governed by US FDA regulations, so I do not know if the formulation meets the same criteria. There is real no way for me to know if your symptoms are a direct result of taking Fincar. I also do not know about the additives and other inactive ingredients in the formulation. I am not aware that the official, U.S. brand of Propecia is associated with aching testicles or thinning eyebrows or dry, wrinkly skin. I am curious to know why you took the medication if you had read “numerous” reports that such drug will cause these problems.

Fincar may have caused your symptoms, but it may also have been coincidental. I suspect you do not want to take another chance. It is always a “buyer beware” market. Seek competent medical advice. I hope you return to “normal”




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Propecia Questions, Part 1 – Balding Blog

Note: I’m just going to post my answer under each question to make it easier for everyone to understand. The email I received from this writer was well researched and quite long, so I’m breaking this into 2 parts. Enjoy part 1 below, and check back for part 2 tomorrow…

1. Is it easy to fake or re-create the standard Merck packaging of Propecia and/or Proscar? I’m asking because of concerns over the legitimacy of these products when purchased from online pharmacies.

Anything is possible. It is always a buyer beware market. Furthermore, you should be evaluated by a qualified doctor before beginning any medications. Propecia can only be precribed by a doctor.

2. The patent for Proscar & Propecia is expiring on June 19th of this year. Have you heard of any developments with regards to other companies wanting to manufacture the generics? Does Merck itself plan to deliver a generic version?

If you remember few years back when Prilosec (omeprazole) became generic, it became less expensive, but the company who made Prilosec then made Nexium (esomeprozole) which is basically the same class of drug and it was marketed successfully as a replacement. I assume something similar may happen, but that is just a guess. I am not in the know and I don’t have inside knowledge. I believe the patent for Proscar runs out this year, but the patent for Propecia (same drug, just 1mg) is still valid for a few more years.

3. Does DHT serve a valuable purpose in the body that is being negated by use of finasteride?

DHT plays a key role in the development and progression of benign prostatic hyperplasia (BPH). Blocking DHT is actually beneficial in preventing prostate cancer according to recent scientific papers which have been published with the 5mg does of finasteride (Proscar).

4. It has been stated that blocking the reduction of testosterone into DHT actually increases the amount of testosterone in the body.
a. Do these raised levels persist or does the body adjust?
b. Given its effects on the hormonal system, I often regard finasteride in the same light as certain steroids even though the action of finasteride on the hormonal system is indirect. Nonetheless, should I be concerned with things like HPTA shutdown, normally an issue for steroid users?

Testosterone is converted to DHT which is then converted to other metabolites. Thus, one may argue that blocking DHT formation may increase testosterone. But there are other biochemical pathways for testosterone to be broken down. It has been said that blocking DHT may slightly increase normal estogen levels (yes, men have estrogen hormones which is normal), but there have been no adverse side effects associated with taking a DHT blocker such as Propecia. Finasteride is not a steroid.

5. Should we be concerned with the effects of finasteride on the liver? I mean, if the drug is to serve its purpose, it must be taken for life.

Finasteride has been approved by the FDA and it does not have adverse effects on the liver. DHT blockers like Propecia will be less strongly metabolized if your liver is functioning poorly, so please check with your doctor for dosing instructions if you have known liver disease.

Stay tuned for part 2 with more questions and answers, which I’ll post tomorrow…




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Will Propecia Thicken the Hairline?, Follow-Up – Hair Loss Information by Dr. William Rassman

I sent you the question which you titled “Will Propecia Thicken the Hairline“.

I don’t have a good digital camera so I’m unable to take reliable pictures for you but I think I can help color the situation with more detail. As I mentioned earlier I’m 25 years old and have a Norwood 1.5 – 2 hairline with thinning in the area around the hairline of 2 -3 cm. The worst area is due north of my temples and isn’t a usually area to lose if your hairline is just maturing. My father is a Norwood 5 and has been since his mid 30’s. The thinning the crown area and diffuse thinning in the hairline indicate to me that I will progress like my father considering my age. I’ve been on propecia for 7 months and it has stopped my hairloss in the vertex and possible slowed the thinning in the front, although as you know it’s difficult to assess even if you are going to a doctor regularly. Taken that propecia is effective in me is it reasonable to think that I will keep the hair behind my hairline given that it hasn’t been significantly effected my MPB? I don’t expect propecia will help thicken the hair in the hairline as it hasn’t done so yet but would it be acceptable to expect I will keep most of the hair that hasn’t been effected my MPB yet? I hope there is more clarity here.

There are no guarantees that Propecia will stop the progression of hair loss. In fact, the studies on the medication show that the loss continues, starting possibly at a higher level of growth on the curves accounting for hair gains seen. Please refer to this graph (click it to see full size), which was made available by Propecia’s manufacturer, Merck. Note that the green curve (those on Propecia) has a less significant downward slope than the gray curve (the control group). This suggests to me that beyond the 5th year that the hair counts will not be droping as fast in the treated group (I wish the actual data had been made available to me).

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Wife Refuses Sex If I Take Propecia – Hair Loss Information – Balding Blog

I used Proscar in the past and it worked well in stopping hair loss and improved hair growth. I stopped it a couple years ago when I got married because my wife thought she would or could get cancer if any of my semen got inside her or even touched her (because of Mercks disclaimers about potential affects on a male fetus). She is very paranoid with tremendous anxieties, so I stopped using it. My hairloss increased greatly. I want to use it again but she is very stubborn and says “no sex if I do.” Can you tell me if there is any potential that my semen can harm her in anyway if I am taking Proscar or Dutasteride or any other Alpha blocker?
Thank you.

Block Quote

There is no evidence that women are at any risk from men who take Propecia, Proscar, or Avodart. This includes any fluid pass through from sperm (intercourse) or saliva (kissing). With regard to Propecia, the drug company has already cleared the drug for young men and the FDA would have never released it without appropriate warnings if any of the medication passed from man to woman.

Now with that said, what I am suggesting is that taking medications that impacts your wife to such a degree as you outlined above, is probably not worth the therapy that it may require or the potential to ruin your marriage. If you push on this, then you may create an unhealthy marriage.

If you find the balding option not acceptable and the medication something that does not work for you and her as a long term couple, then hair transplants are worth exploring. You are not alone, as many men find it unacceptable to take medication on a long term basis (even with my belief and the FDA assurance that the drug is safe in the long term for women who have sex with men taking Propecia). Hair transplants are good options for someone like you, assuming you qualify.

I Lost My Hair When I Switched from Rogaine to Propecia – Hair Loss Information by Dr. William Rassman

Dr. Rassman,

I’m 25. When I was 19 or so, I noticed some serious thinning and began using Rogaine. It seemed to stabilize the situation for me, until I started noticing more and more hair in the bath tub. 8 months ago I decided to give propecia a shot and I’ve been on it since. When I began propecia, I stopped applying the minoxidil and I’ve since noticed some significant hairline reduction! The rear top seems to have thickened, but all of the sudden my hairline got far worse.

I’m concerned that the follicles near my hairline (admittedly, I applied most of the minoxidil to the front of my scalp) got minoxidil dependant in some sense? Is this possible? What should I do now? Resume the minoxidil or kiss it goodbye?

Thanks!

Provided that it has not been too long (a few months at most) restarting Rogaine may restore some of that Rogaine dependent hair. Rogaine is known to produce hair that depends upon its twice daily use. Give it a try.

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Only 50% of My Hair Grew Back After Chemo 6 Years Ago – Hair Loss Information by Dr. William Rassman

Dear Dr. Rassman,

I had a chemotheapy in 2000 and lost all my hair. Then it didn’t fully come back and now I still have diffuse alopecia. I can say only %50 of my hair came back. I also had lots of grey hair but they are now replaced by black colour hair, my original hair colour.

Do you think if I use Pantogar Capsules 3 times a day, will I get any results? If not, which medicine do you suggest to use?

Thanks a lot!

Hair loss from chemotherapy usually grows back without any supplements. I am not aware of any supplements or medication that will accelerate this process. The only treament I know of is “time”. I realize chemotherapy has the stigmata of cancer and is often devastating and depressing for your morale and self image. You must be sure that you do not have other systemic causes of hair loss and your treating doctor should advise you on this.

The time you are taking to grow your hair back appears much longer than most. This may indicate that you will not return it all. If you are disease free and you have what we call a positive nitrogen balance (good diet adding calories to you), then you are doing the most that you can do. There are many organizations or some hospitals have great hair piece or wig programs for their chemotherapy patients.

As I have written in a previous blog entry, I am not familiar with Pantogar, but did find this site which mentions it: EHRS.org

Facial Hair from Rogaine for Women – Hair Loss Information by Dr. William Rassman

Hi,
I am 26 years old, female, and hair loss seems to run in my family. After turning 21 my hair started to fall out. My hair is very thin now all over, but more noticeable on the crown. I beleive I have diffused hair loss. I have tried Rogaine but, unfornately had unwanted facial hair growth. The hair grew in but fell out a month later. I also plan to have a child in the next year and hear that hair loss is associated with pregnancy. Is there any other treatments (pills or topical) besides Rogaine than can regrow hair? How much hair loss is expected and will it grow back?

thinning and desperate

Rogaine does get absorbed through the skin (as will any medication you apply to the skin) and facial hair is a rare but known side effect.

There is no way to tell if you will lose hair with pregnancy and I would not revolve my life around what may happen. A baby is a major life changing experience. If you lose hair with pregnancy, you will probably grow it back and I would expect that regrowth to match what you had prior to the pregnancy within a year or so. Unfortunately, there are few good solutions for women in your situation at this time.

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Propecia Gives Me Pimples – Hair Loss Information by Dr. William Rassman

Whenever I take finasteride 1mg I get these red pimples on my face almost like acne. I think it is probably reflex hyperandrogenicity. Is there any solution to this? Without finasteride I can’t fight my hairloss. How can I stop this reflex hyperandrognicity without stopping propecia? I tried reducing the dosage to .5mg .25mg even .10 mg. But all those dosages still made me breakout in my face.

Check with your dermatologist, for you are guessing the diagnosis here. This is not a common complaint with Propecia, but we do see acne in teenagers that is clearly hormonal.